1. Correlations between drug resistance of Beijing/W lineage clinical isolates of Mycobacterium tuberculosis and sublineages: a 2009-2013 prospective study in Xinjiang province, China.
- Author
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Wang XH, Ma AG, Han XX, Gu XM, Fu LP, Li PG, Li FY, Wang QZ, Liang H, Katar A, and Wang LJ
- Subjects
- Adolescent, Adult, Age Factors, Aged, Antitubercular Agents classification, Antitubercular Agents therapeutic use, Child, Child, Preschool, China epidemiology, DNA, Bacterial genetics, Extensively Drug-Resistant Tuberculosis epidemiology, Female, Genes, Bacterial, Humans, Male, Middle Aged, Mycobacterium tuberculosis classification, Mycobacterium tuberculosis genetics, Prevalence, Prospective Studies, Species Specificity, Tuberculosis, Multidrug-Resistant epidemiology, Young Adult, Antitubercular Agents pharmacology, Drug Resistance, Multiple, Bacterial genetics, Extensively Drug-Resistant Tuberculosis microbiology, Mycobacterium tuberculosis drug effects, Tuberculosis, Multidrug-Resistant microbiology
- Abstract
Background: The prevalence of drug-resistant tuberculosis (TB) in Xinjiang is higher than in other regions of China, and Beijing/W lineage Mycobacterium tuberculosis (MTB) is the dominant strain of MTB in Xinjiang. However, information on multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, particularly the correlation between MDR and the Beijing/W lineage and the correlation between drug resistance and the Beijing/W sublineage strains, is limited., Material/methods: We conducted a prospective study to describe the prevalence of MDR/XDR TB, Beijing/W lineage and sublineage strains in Xinjiang in China from 2009 to 2013. All MTB underwent drug susceptibility testing to the first- and second-line anti-tuberculosis drugs. The Beijing/W lineages and sublineages were detected by large-sequence polymorphisms with polymerase chain reaction., Results: A total of 410 clinical isolates were identified. The overall percentage of MDR and XDR cases in Xinjiang was 13.2% (54/410) and 13.0% (7/54), respectively. Overall, 9.8% (14/143) of the Beijing lineage MTB were MDR patients, and 15.6% (40/257) of the Non-Beijing lineage MTB were MDR patients. In the 143 Beijing MTB lineages, 11.2% isolates were in sublineage 105, 15.4% isolates were in sublineage 207, 69.2% isolates were in sublineage 181, and 4.2% isolates were in sublineage 150. None of the isolates were detected in sublineage 142. Significant differences between the Beijing/W and non-Beijing/W strains were observed regarding INH and EMB resistance, respectively., Conclusions: The prevalence of the MDR TB in Xinjiang remains high and imposes challenges for TB control. Four Beijing/W sublineage isolates were observed in Xinjiang. There was no correlation between MDR and the Beijing/W lineage and no correlation between drug resistance and the Beijing/W sublineage strains. Surveillance of the clinical isolates of MTB is recommended to strengthen the identification of MDR/XDR TB and sublineages of the Beijing/W strains.
- Published
- 2015
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