1. Gender differences in clinical characteristics of patients with non‐cystic fibrosis bronchiectasis in different age groups in northern China.
- Author
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Zhou, Yu‐yan, Wang, Yu‐hong, He, Si‐qi, Wang, Wan‐ying, Wang, Xiao‐yue, Li, De‐shuai, Chen, Xiao‐ting, Feng, Xiao‐kai, and Bu, Xiao‐ning
- Subjects
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AGE groups , *BRONCHIECTASIS , *PSEUDOMONAS aeruginosa infections , *CHRONIC obstructive pulmonary disease , *FORCED expiratory volume - Abstract
Introduction: Patient gender has clinical and prognostic implications in non‐cystic fibrosis bronchiectasis, yet the potential effect of gender on clinical characteristics of patients with non‐cystic fibrosis bronchiectasis is still unclear. Objectives: This study aimed to investigate the gender differences in clinical characteristics of patients with bronchiectasis in different age groups in northern China. Methods: A total of 777 patients diagnosed with bronchiectasis were retrospectively included in Beijing Chaoyang Hospital and divided into two groups by gender: the male group and the female group. Each group was then subdivided into two according to their age (≤65 and >65 years). Gender differences in clinical characteristics were compared in all patients with bronchiectasis in the two age groups, respectively. Results: A total of 777 bronchiectasis patients were included. Of these patients, the prevalence of female non‐smokers was substantially higher than that of male non‐smokers (94.0% vs. 36.8%). There were gender differences in etiology of bronchiectasis, with more post‐measles and connective tissue disease in females (p = 0.006 and 0.002 separately) and more chronic obstructive pulmonary disease (COPD) in males (p < 0.001). The male group had a significantly higher C‐reactive protein (CRP) on admission (p = 0.03). Female patients showed a higher forced expiratory volume in 1 s as percentage of predicted volume (FEV1%pred) and forced vital capacity rate of 1 s (FEV1/FVC) (p < 0.001), lower partial pressure of carbon dioxide (PaCO2) (p = 0.04) and hospital costs (p = 0.02) than males, and a higher prevalence of infection with Pseudomonas aeruginosa in >65‐year‐old group (p = 0.019). Conclusions: There were many differences between male and female patients in smoking status, etiology, lung function, blood gas analysis, and hospital costs in all patients or different age groups. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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