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The purpose of this study was to verify a Chinese version of Community of Inquiry (CoI) instrument with learning presence and explore the causal relationships of the factors in the instrument. This study first examined the reliability and validity of the instrument. All four presences had acceptable levels of reliability (all Cronbach's a > 0.765 or higher). The confirmatory factor modeling approach was used to assess its validity. Then, the study used path analysis and regression analysis to explore the causal relationships of the presences. The key findings showed that teaching and social presences directly influenced the perceptions of learning presence. Learning presence was a partial mediating variable of interactional relationship within CoI constructs.

Objective: This study aimed to estimate the temporal trend of osteoarthritis (OA) burden in China by age, sex, and joint sites from 1990 to 2019 and predict the long‐term trend over the next 25 years. Methods: Using data from the Global Burden of Disease Study 2019, we estimated incident cases, prevalent cases, disability‐adjusted life years (DALYs) of OA, and DALYs of OA attributed to high body mass index (BMI), as well as corresponding age‐standardized rates (ASRs) for aforementioned indicies. Estimated annual percentage change (EAPC) and Nordpred age‐period‐cohort model were used to describe temporal trend changes and predict future disease burden. Results: From 1990 to 2019, the ASR of OA incidence increased from 472.53 per 100,000 to 509.84 per 100,000 people (EAPC: 0.36, 95% confidence interval [CI] 0.29–0.44); the ASR of OA prevalence increased from 5,880.58 per 100,000 to 6,330.06 per 100,000 people (EAPC 0.35, 95% CI 0.28–0.42); the ASR of OA DALYs increased from 206.38 per 100,000 to 224.78 per 100,000 people (EAPC 0.40, 95% CI 0.32–0.48). The ASR of OA DALYs attributed to high BMI increased rapidly, especially in men and patients with hip OA. Projections suggest an increasing trend in the incidence, prevalence, and DALYs of OA from 2019 to 2044, with the prevalent cases and DALYs of OA in China expected to increase by approximately 1.5 times over the next 25 years. Conclusion: The disease burden of OA has increased in China over the past 30 years and is expected to continue rising over the next 25 years. [ABSTRACT FROM AUTHOR]

The process of transformation and superposition from the Paleo-Asian Ocean to the Paleo-Pacific Ocean tectonic systems have been a critical scientific issue. However, the final closure of the Paleo-Asian Ocean and the initial subduction time of the Paleo-Pacific Ocean, together with the conversion between them in Northeast China, still remain controversial. The Triassic granites in the Jiamusi Block are located in the key position of Northeast China, recording the conversion process of two tectonic domains. Through systematic geochronology and geochemical studies, it can provide important constraints for revealing the superposition and conversion mechanism of the Paleo-Asian Ocean and the Paleo-Pacific Ocean and the early subduction history of the Paleo-Pacific Ocean plate. In this study, the granites in Jiamusi Block were formed in the Early–Middle Triassic (250–245 Ma), characterized by high Si, rich alkali, poor Mg, and are obviously enriched in light rare earth elements and large ion lithophile elements, depleting in high field strength elements such as Nb, Ta, and Ti. They have typical characteristics of continental magmatic arc, deriving from partial melting of amphibolite facies and garnet amphibolite facies mafic lower crust. Combined with zircon Hf isotope results, zircon εHf(t) values are −6.52 to + 9.79, and the two-stage Hf model ages are 0.6–1.7 Ga, indicating that the magma should be derived from a relative younger crustal source, and some ancient materials may be added. Moreover, based on the spatial-temporal framework and Hf isotope characteristics of magmatism in Northeast China, we believe that the Jiamusi Block belonged to an exotic block. Meanwhile, combined with geochronological and geochemical data of igneous rocks on the Jiamusi Block, we suggest that the evolution of Jiamusi Block was dominated by the Paleo-Pacific Ocean rather than Paleo-Asian Ocean during the Triassic, which means the subduction of Paleo-Pacific Ocean plate initiated at least in Early Triassic. [ABSTRACT FROM AUTHOR]

While current research on the flipped classroom generally focuses on test results and (or) student/teacher perceptions as a measurement of its pedagogical efficacy, students' adaptation to it and the essential conditions for its application are rarely explored. This exploratory case study aims to rectify this by examining how university students adapted to flipped classrooms implemented in a public university in East China. The findings suggest that while the flipped model is impeded by entrenched polarity between students in terms of their learning dispositions and academic competence, students do develop a prototype of theories of learning, a sense of better self through learning from their peers and an awareness of the importance of intrinsic motivation. A gradualist approach is thus proposed for implementing flipped classrooms, which requires longitudinal studies accordingly to understand its long-term effects on learning behavior hitherto left unexplored.

Background Centralized quarantine was applied in response to the coronavirus disease 2019 outbreak. The present study aimed to investigate changes in psychological status of isolated individuals before and after quarantine. Methods Between August 2020 and July 2021, 648 participants completed the following psychometric evaluations before and after centralized quarantine: 9-item Patient Health Questionnaire for depression, 7-item Generalized Anxiety Disorder for anxiety, the Chinese version of the Connor Davidson Resilience Scale for psychological resilience, the Chinese version of the Simplified Coping Style Questionnaire for coping style, Jiang's revised Chinese version of the Perceived Social Support Scale for social support and the Chinese version of the Impact of Events Scale for stress. Results At the beginning of centralized quarantine, 83.2% (n=539) of participants had no depressive mood, 11% (n=71) had mild depressive mood and 5.8% (n=38) had moderate–severe depressive mood. At the end of quarantine, 80.8% (n=524) of participants had no depressive mood, 13% (n=84) had mild depressive mood and 6.2% (n=41) had moderate–severe depressive mood. At the beginning of the centralized quarantine, 86.7% (n=562) of participants had no anxiety, 9.6% (n=62) had mild anxiety and 3.7% (n=24) had moderate–severe anxiety. At the end of quarantine, 85.8% (n=556) of participants had no anxiety, 11.6% (n=75) had mild anxiety and 2.6% (n=17) had moderate–severe anxiety. After 2 weeks of centralized quarantine, anxiety (t=2.175, p<0.05), stress (t=7.453, p<0.01) and three stress subscale scores (p<0.01) decreased significantly; psychology resilience (t=−3.63, p<0.01), tenacity (t=−4.747, p<0.01), active coping style (t=−3.83, p<0.01) and support outside family (t=−3.07, p<0.05) all increased significantly. No significant change was observed in depression, strength, optimism, passive coping style or support inside family. Depression and anxiety scores associated significantly with resilience, stress, coping styles and social support scores. Anxiety (B=0.488, β=0.413, p<0.01), psychological resilience (B=−0.047, β=−0.203, p<0.01) and stress (B=1.475, β=0.167, p<0.1) scores before centralized quarantine were associated with depression after quarantine. Depression (B=0.323, β=0.422, p<0.01), psychological resilience (B=−0.022, β=−0.123, p<0.01) and stress (B=1.408, β=0.207, p<0.01) scores before quarantine also influenced anxiety levels after quarantine. A cross-lagged panel model indicated that depression, anxiety, resilience and stress scores at the first assessment were predictive of depression and anxiety levels at the second assessment. Conclusions Good mental health during centralized quarantine was associated with high scores of psychological resilience, impact of events, coping styles and social support and did not become worse in settings where adequate support was available. [ABSTRACT FROM AUTHOR]

Aim: To determine the associations between the Chinese visceral adiposity index (CVAI) and the risks of all‐cause and cause‐specific mortality. Materials and Methods: A total of 3 916 214 Chinese adults were enrolled in a nationwide population cohort covering all 31 provinces of mainland China. The CVAI was calculated based on age, body mass index, waist circumference, and triglyceride and high‐density lipoprotein cholesterol concentrations. We used a Cox proportional hazards regression model to determine the hazard ratios and 95% confidence intervals (CIs) for risk of mortality associated with different CVAI levels. Results: The median follow‐up duration was 3.8 years. A total of 86 158 deaths (34 867 cardiovascular disease [CVD] deaths, 29 884 cancer deaths, and 21 407 deaths due to other causes) were identified. In general, after adjusting for potential confounding factors, a U‐shaped relationship between CVAI and all‐cause mortality was observed by restricted cubic spline (RCS). Compared with participants in CVAI quartile 1, those in CVAI quartile 4 had a 23.0% (95% CI 20.0%–25.0%) lower risk of cancer death, but a 23.0% (95% CI 19.0–27.0) higher risk of CVD death. In subgroup analysis, a J‐shaped and inverted U‐shaped relationship for all‐cause mortality and cancer mortality was observed in the group aged < 60 years. Conclusions: The CVAI, an accessible indicator reflecting visceral obesity among Chinese adults, has predictive value for all‐cause, CVD, and cancer mortality risks. Moreover, the CVAI carries significance in the field of health economics and secondary prevention. In the future, it could be used for early screening purposes. [ABSTRACT FROM AUTHOR]

Background: To investigate the knowledge, attitudes, and practice (KAP) toward postoperative cognitive dysfunction (POCD) among anesthesiologists in China. Methods: This cross-sectional study was conducted nationwide among Chinese anesthesiologists between December 2022 and January 2023. The demographic information and KAP scores of the respondents were collected using a web-based questionnaire. The mean KAP dimension scores ≥ 60% were considered good. Results: This study enrolled 1032 anesthesiologists (51.2% male). The mean total scores of knowledge, positive attitude, and positive practice were 9.3 ± 1.2 (max 12), 34.8 ± 3.3 (max 40), and 30.6 ± 6.7 (max 40), respectively. The knowledge items with correctness scores < 60% were "the anesthetic drugs that tend to cause POCD" (23.3%) and "Treatment of POCD" (40.3%). Multivariable analysis showed that ≥ 40 years old, master's degree or above, intermediate professional title (i.e., attending physician), senior professional title (i.e., chief physician), and working in tertiary hospitals were independently associated with adequate knowledge. Multivariable analysis showed that the attitude scores, middle professional title, and ≥ 16 years of experience were independently associated with good practice. Conclusions: These results suggest that Chinese anesthesiologists have good knowledge, favorable attitudes, and good practice toward POCD. Still, some points remain to be improved (e.g., the drugs causing POCD and managing POCD) and should be emphasized in training and continuing education. Trial registration: ChiCTR2200066749. [ABSTRACT FROM AUTHOR]

Since China's clean air action, PM 2.5 (particulate matter with an aerodynamic equivalent diameter of 2.5 µm or less) air quality has improved, while ozone (O 3) pollution has become more severe. Here we apply a coupled meteorology–chemistry model (WRF-Chem: Weather Research and Forecasting model coupled to Chemistry v3.7.1) to quantify the responses of aerosol–radiation interaction (ARI) to anthropogenic emission reductions from 2013 to 2017, including aerosol–photolysis interaction (API) related to photolysis rate change and aerosol–radiation feedback (ARF) related to meteorological field change and their contributions to O 3 increases over eastern China in summer and winter. Sensitivity experiments show that the decreased anthropogenic emissions play a more prominent role in the increased daily maximum 8 h average (MDA8) O 3 in both summer (+ 1.96 ppb vs. + 0.07 ppb) and winter (+ 3.56 ppb vs. - 1.08 ppb) than the impacts of changed meteorological conditions in urban areas. The decreased PM 2.5 caused by emission reductions can result in a weaker impact of ARI on O 3 concentrations, which superimposes its effect on the worsened O 3 air quality. The weakened ARI due to decreased anthropogenic emissions aggravates the summer (winter) O 3 pollution by + 0.81 ppb (+ 0.63 ppb), averaged over eastern China, with weakened API contributing 55.6 % (61.9 %) and ARF contributing 44.4 % (38.1 %), respectively. This superimposed effect is more significant for urban areas during summer (+ 1.77 ppb). Process analysis indicates that the enhanced chemical production is the dominant process for the increased O 3 concentrations caused by weakened ARI in both summer and winter. This study innovatively reveals the adverse effect of weakened aerosol–radiation interaction due to decreased anthropogenic emissions on O 3 air quality, indicating that more stringent coordinated air pollution control strategies should be implemented for significant improvements in future air quality. [ABSTRACT FROM AUTHOR]

Xianxian geothermal exploitation area is one of the areas with the best occurrence conditions of geothermal resource in North China, rich in medium and low temperature geothermal resource, and is a typical carbonate geothermal field. However, its hydrogeochemical evolution process is not clear, and no complete conceptual model of geothermal genesis has been established to guide the exploration, development and utilization of geothermal resource in the area. It restricts the sustainable development of regional geothermal resource and the realization of carbon emission reduction targets. In this study, geothermal fluids in the area were collected for testing and analysis in terms of hydrochemical characteristics and stable isotopes. Based on systematic geochemical research, the formation mechanism of geothermal fluids was analyzed, and a conceptual model of geothermal genetic in the study area was established. The main understanding is as follows: the hydrochemical type of geothermal water in the study area is Cl-Na type, and the water-rock interaction is not balanced. The formation of geothermal water in the area is affected by the infiltration of atmospheric precipitation, and it is terrestrial leached water. The flow path of geothermal water is long, the water circulation is slow, and the metamorphism is deep. Dolomite, calcite and gypsum dissolution are the main sources of Mg2+, Ca2+, , and in geothermal water, besides, other minerals containing calcium and magnesium are also part of their sources. The source of geothermal water recharge is atmospheric precipitation, and the recharge elevation of geothermal water is about 619–1069 m. The age of the geothermal water is between 16 000 and 18 000 years. The sulfur in geothermal water mainly comes from the leaching of sedimentary layer. [ABSTRACT FROM AUTHOR]

Aim: Patients with advanced gastrointestinal stromal tumors (GISTs) exhibiting an imatinib plasma trough concentration (IM Cmin) under 1100 ng/ml may show a reduced drug response rate, leading to the suggestion of monitoring for IM Cmin. Consequently, the objective of this research was to create a customized IM Cmin classification model for patients with advanced GISTs from China. Methods: Initial data and laboratory indicators from patients with advanced GISTs were gathered, and the above information was segmented into a training set, validation set, and testing set in a 6:2:2 ratio. Key variables associated with IM Cmin were identified to construct the classification model using the least absolute shrinkage and selection operator (LASSO) regression and forward stepwise binary logistic regression. Within the training and validation sets, nine ML classification models were constructed via the resampling method and underwent comparison through the Brier scores, the areas under the receiver-operating characteristic curve (AUROC), the decision curve, and the precision-recall (AUPR) curve to determine the most suitable model for this dataset. Two methods of internal validation were used to assess the most suitable model's classification performance: tenfold cross-validation and random split-sample validation (test set), and the value of the test set AUROC was used to evaluate the model's classification performance. Results: Six key variables (gender, daily IM dose, metastatic site, red blood cell count, platelet count, and percentage of neutrophils) were ultimately selected to construct the classification model. In the validation set, it is found by comparison that the Extreme Gradient Boosting (XGBoost) model has the largest AUROC, the lowest Brier score, the largest area under the decision curve, and the largest AUPR value. Furthermore, as evaluated via internal verification, it also performed well in the test set (AUROC = 0.725). Conclusion: For patients with advanced GISTs who receive IM, initial data and laboratory indicators could be used to accurately estimate whether the IM Cmin is below 1100 ng/ml. The XGBoost model may stand a chance to assist clinicians in directing the administration of IM. [ABSTRACT FROM AUTHOR]

During pipeline construction and operation, the occurrence of surface dents presents a critical concern, primarily arising from factors such as pipeline installation and geological forces exerted upon the pipeline, particularly in the form of rock protrusion. These dents pose a significant threat to the pipeline's safe functionality and have the potential to diminish its load-bearing capacity. Presently, China's oil and gas pipelines predominantly employ X80 high-grade steel. It is noteworthy that prior research into the ultimate load capacity of dented pipelines has largely centered on medium and low-grade steels. The implications of these findings for the suitability of the X80 pipeline remain inconclusive. Consequently, it is imperative to undertake a comprehensive investigation into the load-bearing capacity of high-grade steel pipelines with dent defects. In addition to internal pressure, variations in the pipeline's transported medium, ambient temperature fluctuations, soil displacement, and other factors introduce additional loading effects, including bending moments and axial loads. These supplementary loads introduce latent hazards to the pipeline's operational safety. Hence, this research endeavors to investigate the ultimate load-bearing capacity of X80-grade dented pipelines under the influence of typical loading conditions and to identify pertinent factors that affect this capacity. Finite element analysis (FEA) is deployed to study the behavior of the dented pipelines under typical loads. Failure criterion for ascertaining the ultimate load is proposed and verified by the comparison to test results. Furthermore, the impact of varying dent sizes on the ultimate load capacity of X80-grade dented pipelines is examined. These findings serve as a robust foundation for the safety assessment of dented pipelines, ensuring the sustained safe operation of these vital infrastructures. [ABSTRACT FROM AUTHOR]

Agricultural soil serves as a crucial reservoir for microplastics (MPs), necessitating an understanding of their global‐scale environmental impacts and potential risks that they pose to agricultural soil and crops. Little is known about the potential impact of MPs in agricultural soils, compared with MPs in aquatic sediments, especially their effects on crop traits. The purpose of our study was to explore whether different types, concentrations, sizes, and exposure time of MPs, as well as soil conditions (such as soil pH or organic matter concentration), have different effects on soil properties and crop traits. In addition, differences between soil and crop enzymes in response to MPs were compared in detail. Network analysis was used to understand the current research progress on MPs in agricultural soil. Furthermore, utilizing 63 publications and 3268 observations, a meta‐analysis was conducted to analyze the effects of MPs on soil properties and crop traits. Our result showed that China has contributed the most to MP research. Crop traits, rather than soil properties, were more sensitive to MPs, significantly increasing crop biochemical traits (p < 0.05) and decreasing crop morphological traits (p < 0.001). MPs significantly inhibited fruit, shoot, and root morphological traits by 13.34% (p < 0.05), 9.7% (p < 0.001), and 6.65% (p < 0.001), respectively; inhibited crop physiological traits such as photosynthesis, respiration, and transpiration by 9.1% (p < 0.001), 34.44% (p < 0.001), and 14.74% (p < 0.05), respectively; inhibited crop biochemical traits such as organic and inorganic metabolites， and improved enzyme activity by 11.37% (p < 0.001), 10.07% (p < 0.001), and 10.16% (p < 0.001), respectively. MPs decreased soil enzyme activities of leucine aminopeptidases and sucrase by 7.22% (p < 0.01) and 27.26% (p < 0.001), respectively, and increased peroxidase, acid phosphatase, catalase (CAT), and urease activities by 59.21%, 7.34%, 6.86%, and 13.13%, respectively. MPs increased crop enzyme activities of CAT and malondialdehyde by 12.71% and 14.82%, respectively. Conclusively, the effect of MPs on crop traits warrants considerable attention and an urgent need to explore whether MPs cause differences between crops with regard to crop traits. [ABSTRACT FROM AUTHOR]

Since China's clean air action, PM2.5 air quality has been improved while ozone (O3) pollution has been becoming severe. Here we apply a coupled meteorology-chemistry model (WRF-Chem) to quantify the responses of aerosol-radiation interaction (ARI), including aerosol-photolysis interaction (API) and aerosol-radiation feedback (ARF), to anthropogenic emission reductions from 2013 to 2017, and their contributions to O3 increases over eastern China in summer and winter. Sensitivity experiments show that the decreased anthropogenic emissions play a more prominent role for the increased MDA8 O3 both in summer (+1.96 ppb vs. +0.07 ppb) and winter (+3.56 ppb vs. -1.08 ppb) than the impacts of changed meteorological conditions. The decreased PM2.5 caused by emission reduction can result in a weaker impact of ARI on O3 concentrations, which poses a superimposed effect on the worsened O3 air quality. The weakened ARI due to decreased anthropogenic emission aggravates the summer (winter) O3 pollution by +0.81 ppb (+0.63 ppb) averaged over eastern China, with weakened API and ARF contributing 55.6 % (61.9 %) and 44.4 % (38.1 %), respectively; this superimposed effect is more significant for urban areas during summer (+1.77 ppb). Process analysis indicates that the enhanced chemical production is the dominant process for the increased O3 concentrations caused by weakened ARI both in summer and winter. This study innovatively reveals the adverse effect of weakened aerosol-radiation interaction due to decreased anthropogenic emissions on O3 air quality; more stringent coordinated air pollution control strategies are needed for future air quality improvement. [ABSTRACT FROM AUTHOR]

Investigating the impacts of climatic factors and human activities on sedimentary records of heavy metal (HM) contamination in lakes is essential for decision-making in global environmental monitoring and assessment. Spatiotemporal distributions of grain size (GS) and HM (Al, Cr, Mn, Ni, Cu, Zn, As, and Pb) concentrations have been conducted in core sediments that are collected from two adjacent plateau fault-bound lakes in southwest China with contrasting environments, i.e., deep oligotrophic Lake Fuxian (FX) and shallow hypertrophic Lake Xingyun (XY). Results showed that the average value of d50 in FX (4.61 μm) was lower than that in XY (8.35 μm), but the average concentrations of HMs (except Cr and Mn) in XY were higher than those in FX. Heavy metal burial rates (HMBR) were mainly controlled by sediment accumulation rates (SARs) rather than HM concentrations. The correlation coefficients between GS and HM concentrations became strong as the increasing water depths were associated with a stable sedimentary environment. Time-integrated enrichment factors (EF) and source identification of HMs between FX and XY represented that Cr, Ni, and Cu originated from natural sources but Mn, Zn, As, and Pb from anthropogenic sources, respectively. Regardless of FX and XY, the transition times of HMs from natural to anthropogenic sources occurred in the mid-1960s. Comparison of qualification impacts of climatic factors and human-induced factors on increased anthropogenic HMBR by the partial least squares path modeling (PLS-PM) implied that socio-economic activities, such as population density (PD) and gross domestic product (GDP), provided higher contributors to increased anthropogenic HMBR in XY (0.23/0.71) than FX (0.11/0.18). The comparative results of this study provided new insights into environmental monitoring and management of HM contamination for adjacent lakes with contrasting environments. [ABSTRACT FROM AUTHOR]

Modern cities require urban compact development to be sustainable. The evaluation of urban compact development may help create more accurate and realistic policies. The spatio-temporal dynamic evolution of urban compact development efficiency and its regional differences in China are examined in this study. This paper analysis uses 282 cities from 2005 to 2021. The unexpected output super-efficiency SBM model measures urban compact development efficiency. In this study, the urban compact development efficiency's spatial and temporal patterns are also examined using kernel density estimation (KDE) and the Theil index (TI). The average efficiency of urban compact development in China has decreased slightly. However, compact efficiency disparities are decreasing. Eastern cities have a relatively stable compact efficiency, while central and western cities vary more. The compact efficiency polarisation has not changed fundamentally. The compact city growth model's spatial agglomeration is poor, limiting its spatial spillover impact. Thus, compact urban development is necessary to speed up planning, facilitate inter-city production factor movement by creating a comprehensive transport network, and maximise co-location benefits with the regional integration strategy. This method will gradually reduce regional urban development disparities and push Chinese cities towards more refined and sustainable compact development. [ABSTRACT FROM AUTHOR]

We study the effects of the US-China trade war on Chinese firms' investment using the detailed quarterly financial data of Chinese listed firms merged with firm-level Chinese customs data. We construct the firm-level measures of direct trade exposure and the financial measures of indirect exposures to the US-China trade tension using firms' equity responses during the trade war escalation periods. We document that the trade war reduced Chinese firms' investment by two percent. In particular, we find significant heterogeneous firms' responses to the trade war, depending on their firm characteristics. Chinese firms that are more dependent on exports to the US have lower stock returns; large firms and state-owned firms suffer more compared to small firms and private-owned ones. [ABSTRACT FROM AUTHOR]

Under the background of China's high-quality development, improving the ecological environment, enhancing the welfare level of residents and promoting the sustainable development of cities have become a hot issue of widespread concern in society. This paper focuses on the Yangtze River Delta region, aiming to study the direct incentive effect and spatial spillover effect of creating a national health city on the ecological welfare performance. It also further decomposes the spatial spillover effect, to study the path of spatial spillover and the characteristics of heterogeneity in different regions. The results show that (1) the ecological welfare performance in the Yangtze River Delta is increasing year by year, and the average growth rate was 0.23%. There is a spatial effect of "beggar-thy-neighbor." The improvement of local ecological welfare performance will reduce the performance level of the surrounding areas by more than 30%. (2) To create a national health city in local areas, the ecological welfare performance in local areas will be increased by 0.087%, and the ecological welfare performance in the surrounding areas will be increased by 0.031%. Among them, the ecological welfare performance of the surrounding national health cities will be increased by 0.067%, and the ecological welfare performance of the surrounding non-health cities will not be significantly improved. (3) The effect has heterogeneity in coastal and inland areas. In terms of direct incentive effect, coastal areas are more obvious than inland areas. In terms of spatial spillover effect, inland areas show more positive spatial spillover effect than coastal areas, whether in groups or within groups. This paper is the first time to study this issue, enhance the theory, and practice of ecological welfare performance. [ABSTRACT FROM AUTHOR]

Agricultural non-point pollution has become a hot topic of social concern, and the three major industries in modern rural areas gradually tend to integrate. An in-depth study of the impact of rural industrial integration on agricultural non-point pollution has important guiding significance for the realization of sustainable agricultural development. Based on the panel data of 30 provinces and municipalities in China from 2011 to 2019, this paper explores the impact of rural industrial integration on agricultural non-point source pollution and further examines the moderating effect of urbanization. The main findings are as follows. First, there is a significant inverted U-shaped relationship between rural industrial integration and agricultural non-point source pollution. At present, rural industrial integration has a tendency of alleviating agricultural non-point source pollution. Second, urbanization has a moderating effect on the impact of rural industrial integration on agricultural non-point source pollution, moving the turning point of the curve to the left, which can accelerate the arrival of the emission reduction effect of rural industrial integration. Finally, the heterogeneity test shows that compared to areas with developed economies and weak financial support, the inverted U-shaped relationship between rural industrial integration and agricultural non-point source pollution is more significant in regions with underdeveloped economies and strong financial support. The above studies enrich the relevant literature on rural industrial integration and agricultural non-point source pollution and provide a theoretical basis for the government to formulate relevant policies for promoting the development of rural industrial integration and alleviating agricultural non-point source pollution. [ABSTRACT FROM AUTHOR]

Background: Tyrosine kinase inhibitors combined with conventional chemotherapy (CC) in treating Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL) has achieved promising efficacy and safety outcomes. The study was conducted to compare the cost-effectiveness between imatinib (HANSOH Pharma, Jiangsu, China) and dasatinib (CHIATAI TIANQING Pharma, Jiangsu, China) in treating pediatric Ph-positive ALL when combined with CC from the perspective of the health system in China. Methods: A Markov model was established to simulate a hypothetical cohort of pediatric Ph-positive ALL patients receiving imatinib or dasatinib, combined with CC. The model was designed using a 10-year horizon, a 3- month cycle, and a 5% discount rate. Three health states were included: alive with progression-free survival, progressed disease, and death. Patient characteristics and transition probabilities were estimated based on clinical trials. Other relevant data, such as direct treatment costs and health utility data were extracted from published literature and Sichuan Province's centralized procurement and supervision platform. One-way sensitivity analysis and probabilistic sensitivity analysis were performed to assess the robustness of the results. The willingness-to-pay (WTP) was set as three times China's GDP per capita in 2021. Results: In the base-case analysis, the total medical costs were $89,701 and $101,182, and the quality-adjusted life years (QALYs) gained were 1.99 and 2.70, for imatinib and dasatinib regimens, respectively. The incremental cost-effectiveness ratio for dasatinib versus imatinib was $16,170/QALY. The probabilistic sensitivity analysis indicated that treatment with dasatinib combined with CC achieved a 96.4% probability of cost-effectiveness at a WTP threshold of $37,765/QALY. Conclusions: Dasatinib combined with CC is likely to be a cost-effective strategy compared to imatinib combination therapy for pediatric Ph-positive ALL in China at a WTP threshold of $37,765/QALY. [ABSTRACT FROM AUTHOR]

The rapid development of industrialization and urbanization has posed serious challenges for coastal farmland ecosystems. Source apportionment of soil heavy metals is an effective way for the detection of non-point source pollution in farmland to help support the high-quality development of coastal agriculture. To this end, 113 surface soil samples were collected in the coastal delta of China, and the contents of As, Cd, Cr, Cu, Ni, Pb, and Zn were determined. A variety of models were integrated to apportion the source of soil heavy metals, including positive matrix factorization (PMF), geographical detector (GD), eXtreme gradient boosting (XGBoost), and structural equation modeling (SEM). The result of PMF models revealed that there was collinearity between various heavy metals, and the same heavy metal may have a mixed source. The XGBoost model analysis indicated that there were significant non-linear relationships between soil heavy metals and source factors. A synergy between air quality and human activity factors was the key source of heavy metal that entered the study area, based on the results of the GD. Furthermore, the input path effect of heavy metals in the soil of the study area was quantified by SEM. The balance of evidence from the above models showed that air quality (SO2 and NO2) and factories in the study area had the greatest impacts on Cd, Cr, and Zn. Natural sources were dominant for Pb, while As, Cu, and Ni were contributed by soil parent material and factories. The above results led to the conclusion that there was a cycle path in the study area that continuously promoted the migration and accumulation of heavy metals in farmland soil; that is, the heavy metals discharged during oil exploitation and smelting entered the atmosphere and then accumulated in the farmland soil through precipitation, atmospheric deposition, and other paths. In this study, it is shown that a variety of models can be used to more comprehensively assess the sources of soil heavy metals. This approach can provide effective support for the rapid prevention and decision-making management of soil heavy metal pollution in coastal areas. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the multiple factors influencing the survival of elderly patients with locally advanced gastric cancer (LAGC) and develop and validate the novel nomograms for predicting the survival. Methods: The clinical features of patients treated between 2000 and 2018 were collected and collated from the Surveillance, Epidemiology, and End Results (SEER) database and three medical centres in China, and the patients were randomly divided into a training cohort (3494), internal validation cohort (1497) and external validation cohort (841). Univariate and multivariate analyses of the prognostic values were performed to identify independent prognostic factors associated with overall survival (OS) and cancer-specific survival (CSS), and two nomogram models were developed. Harrell's concordance index (C-index) and calibration curves were employed to assess discrimination and calibration. Decision curve analysis (DCA) and receiver-operating characteristic (ROC) curves were utilized to investigate the clinical usefulness. Results: In the SEER database, the 5-year OS of the patients was 31.08%, while the 5-year CSS of the patients was 44.09%. Furthermore, in the external validation set, the 5-year OS of the patients was 49.58%, and the 5-year CSS of these patients was 53.51%. After statistical analysis, nine independent prognostic factors of OS and CSS were identified, including age, race, tumour size, differentiation, TNM stage, gastrectomy type, lymph node metastasis (LNM), lymph node ratio (LNR) and chemotherapy. The C‐index (approximately 0.7) and calibration curve (close to the optimal calibration line) indicated satisfactory discrimination and calibration of the nomogram. DCA and ROC curves showed that the developed nomogram was superior to TNM stage. Conclusion: The novel validated nomogram could accurately predict the prognosis of individual elderly patients with LAGC and guide the selection of clinical treatment measures. [ABSTRACT FROM AUTHOR]

The applicability of statistics-based landslide susceptibility assessment methods is affected by the number of historical landslides. Previous studies have proposed support vector machine (SVM) as a small-sample learning method. However, those studies demonstrated that different parameters can affect model performance. We optimized the SVM and obtained models as 5-fold cross validation (5-CV) SVM, genetic algorithm (GA) SVM, and particle swarm optimization (PSO) SVM. This study compared the prediction performances of logistic regression (LR), 5-CV SVM, GA SVM, and PSO SVM on landslide susceptibility mapping, to explore the spatial distribution of landslide susceptibility in the study area in Tibetan Plateau, China. A geospatial database was established based on 392 historical landslides and 392 non-landslides in the study area. We used 11 influencing factors of altitude, slope, aspect, curvature, lithology, normalized difference vegetation index (NDVI), distance to road, distance to river, distance to fault, peak ground acceleration (PGA), and rainfall to construct an influencing factor evaluation system. To evaluate the models, four susceptibility maps were compared via receiver operating characteristics (ROC) curve and the results showed that prediction rates for the models are 84% (LR), 87% (5-CV SVM), 85% (GA SVM), and 90% (PSO SVM). We also used precision, recall, F1-score and accuracy to assess the quality performance of these models. The results showed that the PSO SVM had greater potential for future implementation in the Tibetan Plateau area because of its superior performance in the landslide susceptibility assessment. [ABSTRACT FROM AUTHOR]

The current study aimed to investigate Chinese immigrants' sleep quality and associations between the coronavirus disease 2019 pandemic's impact and racism and sleep disruption using a cross-sectional online survey. A total of 507 Chinese immigrants were recruited via social network sites. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. The pandemic's impact and racism were measured using questions developed for this study. More than 42% of participants reported poor sleep quality. Those who reported having been affected by the pandemic had poorer subjective sleep quality, longer sleep latency, and greater daytime dysfunction. Those who experienced racist incidents were more likely to use sleep medication and exhibit poor subjective sleep quality, long sleep latency, short sleep duration, and daytime dysfunction. Chinese immigrants' sleep health warrants particular consideration by health care professionals. Timely, effective interventions, such as relaxation techniques and online psychoeducation, need to be delivered in the Chinese community. [Journal of Psychosocial Nursing and Mental Health Services, 61(4), 45–51.] [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to establish a new nomogram that predicts recurrence-free survival (RFS) after a complete surgical resection of primary localized gastrointestinal stromal tumors (GISTs); it also aimed to evaluate the discrimination, calibration, and clinical utility of the decision-making nomogram. Methods: The clinicopathological data of patients with primary localized GISTs at the First Affiliated Hospital of Chongqing Medical University from January 2000 to June 2022 were retrospectively analyzed. The clinicopathological data were randomly split into two sets (7:3 ratio) for training and validation. Suitable variables for the construction of a nomogram for the 1-, 3-, and 5-year RFS were selected using univariate and multivariate Cox regression analyses. Receiver operating characteristic (ROC) analysis and a concordance index (C-index) were used to quantify the discrimination of the nomogram and were compared with four commonly used prognostic scoring systems: Memorial Sloan Kettering Cancer Center prognostic nomogram, National Institutes of Health–Fletcher staging system, Chen's prognostic nomogram, and Air Forces Institute of Pathology risk criteria–Miettinen staging system. The calibration and clinical utility for the decision-making nomogram were validated using calibration curves and decision curves, respectively. Results: In total, 641 patients were screened and analyzed in this retrospective, observational study. RFS was significantly related to tumor size, mitotic count, gender, DOG-1, and adjuvant therapy with imatinib according to the results of the multivariate and univariate Cox analyses. The nomogram was constructed using the above variables (all p < 0.05) for the 1-, 3-, and 5-year RFS. In the training set, the 1-, 3-, and 5-year ROC and C-index values of the nomogram were 0.868, 0.838, 0.816, and 0.830, respectively. For internal validation, we performed model fitting on the validation set, and the 1-, 3-, and 5-year ROC and C-indices were 0.977, 0.845, 0.869, and 0.849, respectively. Among the five GIST prognostic scoring systems, our nomogram had almost all the largest area under these decision curves and had a good calibration capability. Conclusions: The newly constructed nomogram based on tumor size, gender, mitotic count, DOG-1, and adjuvant treatment with imatinib exhibited an excellent performance and may serve as a prognostic scoring system to support therapeutic decision-making and individualized treatment for GISTs in China. [ABSTRACT FROM AUTHOR]

Accurate wind speed prediction plays a crucial role in wind power generation and disaster avoidance. However, stochasticity and instability increase the difficulty of wind speed prediction. In this study, we proposed a dual-attention mechanism multi-channel convolutional LSTM (DACLSTM), collected European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis v5 (ERA5) near-ground element-grid data from some parts of North China, and selected elements with high correlations with wind speed to form multiple channels. We used a convolutional network for the feature extraction of spatial information, a Long Short-Term Memory (LSTM) network for the feature extraction of time-series information, and used channel attention with spatial attention for feature extraction. The experimental results show that the DACLSTM model can improve the accuracy of six-hour lead time wind speed prediction relative to the traditional ConvLSTM model and fully connected network long short-term memory (FC_LSTM). [ABSTRACT FROM AUTHOR]

A new HP-PRRSV strain (SD2020) was isolated from pigs with suspected highly pathogenic porcine reproductive and respiratory syndrome disease in a pig farm in Shandong Province, China, and its genome was sequenced. This pig farm has been using the VR-2332 vaccine strain to immunize pigs for a long time. The phylogenic and single nucleotide polymorphisms (SNPs) analysis of the viruses isolated from dead pigs showed that SD2020 was a natural recombinant virus of the VR-2332 vaccine strain and the JXA1 similar strain, and that two splicing fragments highly homologous to JXA1 in the virus genome were probably derived from the JXA1 wild strain and JXA1-R vaccine strain, respectively. Therefore, the possible recombination events of SD2020 and its mutation site might be related to high pathogenicity. [ABSTRACT FROM AUTHOR]

Accurate and reliable runoff prediction is essential for water resources management. In this paper, a hybrid model STL-VMD-SFO-ESN which combines seasonal adjustment method (STL), variational mode decomposition (VMD), echo state network (ESN) and sailed fish optimizer (SFO) is proposed for daily runoff prediction. Daily runoff data from three different runoff monitoring stations in China's Yellow River basin is used to evaluate the performance of proposed model and other newly reported models. The results indicates that: (1) The proposed model performs significantly better than the traditional data-driven models and some newly reported models. (2) STL decomposition can effectively remove the seasonal component of runoff and improve modeling accuracy. (3) ESN has a strong potential in runoff prediction, and its performance can be greatly improved by using bio-optimization algorithms. Thus, this new model has strong potential for runoff prediction for further application. [ABSTRACT FROM AUTHOR]

Simple Summary: This study was carried out to investigate the nutrient compositions of alfalfa, tall fescue and tall fescue + alfalfa mixed grassland under different mowing stubble times and clarify their correlation with in vitro digestibility. In vitro dry matter digestibility of alfalfa, tall fescue and tall fescue + alfalfa were predicted by their nutrient composition respectively. The results demonstrated that these models based on nutrient composition could accurately predict the in vitro dry matter digestibility of alfalfa monoculture, tall fescue monoculture and alfalfa + tall fescue mixture, respectively, and provide a forage utilization mode for sown pasture. Mowing, Mowing, which affects the nutritional levels of grasslands, is the main utilization of sown pasture. We sowed alfalfa monoculture grassland, tall fescue monoculture grassland and tall fescue + alfalfa mixed grassland in typical steppe of the Loess Plateau to investigate the nutrient compositions and in vitro degradability of those three grasslands under different mowing stubble times and to provide reference for nutrient management of sown pastures. The results showed that the stubble time significantly affected (p < 0.05) the nutrient compositions and mineral elements of forages in alfalfa monoculture grassland, whereas had no effects on the nutrient compositions and dry matter digestibility of forages in tall fescue monoculture grassland and alfalfa + tall fescue mixed grassland. The relative feeding value of mixed grassland of alfalfa and tall fescue was increased by 2.6–22.4% as compared to monoculture grasslands. The model constructed based on forage nutrient content could accurately predict the forage dry matter degradability of alfalfa monoculture, tall fescue monoculture and mixed alfalfa and tall fescue, respectively. [ABSTRACT FROM AUTHOR]

Twelve new specimens of sporidesmium-like taxa were collected from freshwater habitats in China and Thailand. Phylogenetic analysis of nuc 28S rDNA (LSU), internal transcribed spacer (ITS), translation elongation factor 1-alpha (TEF1-α) and second-largest subunit of RNA polymerase II (RPB2) sequence data, combined with morphological data, revealed that they are Distoseptispora species. Among them, six new species, including D. aqualignicola, D. aquamyces, D. crassispora, D. curvularia, D. nonrostrata and D. pachyconidia, are introduced. Two new combinations, D. adscendens and D. leonensis, are transferred from Ellisembia. A new habitat and geographical record are reported for D. clematidis, collected from a freshwater habitat in China. New RPB2 sequence data for D. dehongensis are provided. [ABSTRACT FROM AUTHOR]

Due to the nexus of wealth effect and cost effect, the impact of housing price on fertility is ambiguous in theory. However, the relation between housing price and fertility is essential for policymakers, especially in developing countries. This paper constructs an individual-level panel data set of over 40,000 randomly selected Chinese females with detailed fertility history during 2006–2010 from the Census 2010. Exploiting variation of housing price growth across cities over time and conditional on marriage status, we show that a 1,000 yuan upward shift in housing price induces the possibility of new birth by 13.9% for homeowners. Homeownership plays a vital role in housing price on fertility. These findings suggest that the wealth effect of housing price dominates the cost effect during the sample periods in China. [ABSTRACT FROM AUTHOR]

[Display omitted] • The peak of high grade metamorphism has been constrained to occur at 566–565 Ma, proving the Jiamusi-Kuunga-Pinjarra linkage. • The continental crust of the Jiamusi Block is featured by a progressive rather than episodic growth pattern. • Diverse forms of crustal growth have been defined in an accretionary orogen. There is a considerable debate as to when and how the continental crust has evolved to its present state. Existing studies of crustal evolution have focused on large cratons, whereas microcontinents within accretionary orogenic belts have been conspicuously neglected. The controversial definition of tectonic origins and lack of Precambrian basement rocks of microcontinents, lead to an equivocal issue of their secular crustal evolution processes. Here we present zircon U-Pb ages and Hf-O isotopes, as well as whole-rock elemental and Sr-Nd-Pb-Hf isotopic data for the newly discovered Neoproterozoic orthogneisses from the Jiamusi Block of NE China in the easternmost Central Asian Orogenic Belt (CAOB). LA-ICP-MS U-Pb dating of zircons from the orthogneisses recorded two episodes of magmatism at 896–886 Ma and 752–726 Ma. Combined with zircon Hf-O isotopes and REE patterns, the peak of the late Pan-African metamorphism is proved to occur at 566–565 Ma, demonstrating the linkage between the Jiamusi Block and the Kuunga-Pinjarra interior orogen of East Gondwana. In conjunction with compiled zircon U-Pb-Hf isotopic data of Neoproterozoic-Mesozoic granitoids, a new crustal evolution model has been established for the Jiamusi Block, which defines a continuous rather than an episodic crustal growth pattern during the Neoarchean to Neoproterozoic, as well as four stages of crustal reworking at 940–880 Ma, 780–660 Ma, 560–460 Ma, and 340–240 Ma. The enhanced and reduced rates of crustal growth during the progressive period are related to the assembly-breakup and collision phases of supercontinent cycles, respectively. Our study along with previous researches on eastern CAOB not only highlights that the Phanerozoic accretionary orogen underwent diverse forms of crustal growth with most of the continental crust formed during the Precambrian, but also provides an example to show the heterogeneity of the lower continent and the complexity of global secular crustal evolution. [ABSTRACT FROM AUTHOR]

Background: China now faces an increasingly aging society which may exert economic pressure in the long run. This study illustrates the spatial pattern and evolution of population aging and economic development in China. The coupling coordination degree of population aging and economic development at the national and provincial levels are calculated and demonstrated, and the spatial patterns and characteristics are investigated. Methods: This paper presents a coupling analysis of the elderly population rate (EPR) and per capita Gross Regional Product (GRPpc) in China by using the coupling and coordination model. Further, the spatial pattern and evolution of population aging and economic development are investigated based on the standard deviational ellipse. The collected data is at the level of provincial administrative units in mainland China covering the period 2002 to 2020. Results: The results reveal the spatial difference in the coupling and coordination degree between EPR and GRPpc across provinces. The eastern coastal areas are higher than the central and western regions of China. The orientation and directions of EPR are more than GRPpc, indicating that the polarization in population aging is more severe than economic development. Significant positive correlations between coupling coordination degree and sustainable competitiveness are detected. Conclusions: Policymakers should fully consider regional differences and sustainable development in policy formulation of China. The western and northeastern provinces should be given priority in the regional sustainable development plan. At the same time, the coordination between population aging and economic development also requires to be examined especially. [ABSTRACT FROM AUTHOR]

This paper investigated the dynamic relationship between ife expectancy (LE) and its inflencing factors including, health care, socioeconomic, and environment factors in Beijing City of China. Time-series data from 2000 to 2018 were collected and vector autoregression (VAR) modeling was performed. This study quantified the lagged effect of air pollution and socioeconomic factors on increased LE over the 19 years of the study period in Beijing. The results showed that a VAR model with optimum lag 3 was constructed between LE and three explanatory variables including per capita area of green land (AGL), the average wage of employed staff and workers (WAGE), and PM2.5. In addition, LE showed a decrease from its present value once the impulse of AGL and WAGE are given. In contrast, LE increase from its present value after the impulse of PM2.5 given in the ten-year period analysis. In sum, environment factors such as air pollution and area of green land are considered to be highly effective in influencing LE than socioeconomic factors in Beijing City. [ABSTRACT FROM AUTHOR]

The surface of organic insulating materials such as room temperature vulcanized silicone rubber (RTV) coatings often has serious contamination deposition. In humid areas such as the Southwest region of China, algae contamination layers are present on the surface of the insulators. In this study, the geographical and creeping distribution of algae contamination on the surfaces of RTV insulators were studied by investigating and sampling various substations in the Southwest region. The main components of soluble salts in the contamination were studied by atomic absorption spectroscopy and ion chromatography. The algal genome was extracted by the cetyltrimethylammonium bromide method, and the species of algae and other microorganisms in the contamination layer were determined. The effects of algae or their secretions on the surface resistance and hydrophobicity were studied by quantitatively inoculating algae and smearing extracellular secretions on the RTV surface. The damage of the algae contamination layer to the microstructure of the silicone rubber was investigated by microscopic observation and thermogravimetric analysis. Results showed that the growth of algae was positively correlated with the surface contamination of RTV. The extracellular secretion of algae destroys the surface microstructure of RTV and causes the removal of alumina hydroxide, leading to the reduction of siloxane. Therefore, the resistance and hydrophobicity of the RTV surface were reduced. It is of great significance to study the characteristics and effects of the algae contamination layer for RTV maintenance. [ABSTRACT FROM AUTHOR]

Background: Salmonella is a leading foodborne and zoonotic pathogen, and is widely distributed in different nodes of the pork supply chain. In recent years, the increasing prevalence of antimicrobial resistant Salmonella poses a threat to global public health. The purpose of this study is to the prevalence of antimicrobial resistant Salmonella in pig slaughterhouses in Hubei Province in China, and explore the effect of using lytic bacteriophages fighting against antimicrobial resistant Salmonella. Results: We collected a total of 1289 samples including anal swabs of pigs (862/1289), environmental swabs (204/1289), carcass surface swabs (36/1289) and environmental agar plates (187/1289) from eleven slaughterhouses in seven cities in Hubei Province and recovered 106 Salmonella isolates. Antimicrobial susceptibility testing revealed that these isolates showed a high rate of antimicrobial resistance; over 99.06% (105/106) of them were multidrug resistant. To combat these drug resistant Salmonella, we isolated 37 lytic phages using 106 isolates as indicator bacteria. One of them, designated ph 2–2, which belonged to the Myoviridae family, displayed good capacity to kill Salmonella under different adverse conditions (exposure to different temperatures, pHs, UV, and/or 75% ethanol) and had a wide lytic spectrum. Evaluation in mouse models showed that ph 2–2 was safe and saved 80% (administrated by gavage) and 100% (administrated through intraperitoneal injection) mice from infections caused by Salmonella Typhimurium. Conclusions: The data presented herein demonstrated that Salmonella contamination remains a problem in some pig slaughter houses in China and Salmonella isolates recovered in slaughter houses displayed a high rate of antimicrobial resistance. In addition, broad-spectrum lytic bacteriophages may represent a good candidate for the development of anti-antimicrobial resistant Salmonella agents. [ABSTRACT FROM AUTHOR]

Being one of the most important sources of water in the Jilin Province in China, the Yinma River Basin (YRB) is facing problems of water scarcity in low economic areas and low utilization in richer areas mainly caused by the irrational allocation of water, excessive pursuit of economic benefits, and neglect of environmental problems. Restricting watershed development involves potential decision-making risks. Some scholars have used the interval two-stage stochastic planning method to adjust water resource allocation in the Drinking Horse River Basin, but the method uses historical statistics for projection and does not take into account the ambiguity and uncertainty in real planning situations. Therefore, this study addresses the problems prevalent in the allocation of water resources in the YRB through optimization using stochastic programming methods, interval and two-stage, and introduces the fuzzy mathematical programming method, with the aim of coordinating the water balance of various water-consuming sectors in the YRB, so as to reconfigure the water allocation. The goal is to solve the existing problems of irrational water allocation, reduce system risks posed by excessive economic development, mitigate water shortages in the water-consuming sectors, and alleviate potential decision-making risks and vague uncertainties associated with the allocation of water resources. Additionally, optimization of the pollution-holding capacity improvement project was carried out. The interval fuzzy two-stage model simulation developed in this study shows that the distribution of water across the different administrative regions can be reduced by up to 30% compared with the original model, effectively reducing the problem of water wastage. Post-optimization, the impact of water shortage in the water resources allocation scheme is alleviated to a significant degree, and there is no water shortage in some areas. At the same time, the eco-environmental sector has gradually taken the leading role in the distribution of water reuse among the different water-consuming sectors. The pollution-holding capacity has been enhanced, and the discharge and river entry chemical oxygen demand (COD) and ammonia nitrogen, two typical pollutants, have been reduced. The membership interval in the interval fuzzy two-stage model reflects the relationship between the possible level of the target value and the risk level. This study provides a guideline for decision makers for balancing the relationship between benefits and risks and proposes a planning scheme that is more conducive to the development of the river basin. [ABSTRACT FROM AUTHOR]

Human activities change the natural ecosystem and cause the decline of the intact ecosystem. Establishing an applicable and efficient human activity monitoring indicator system benefits China's ambitious national park system construction. In this study, we established a refined technique for ecological intactness scores (EIS) and applied it in the area of Giant Panda National Park (GPNP) from 1980 to 2020 by quantifying four types of human interferences including land use and cover change (LUCC), road construction, water reservoir and hydropower construction, and mining. The results show the following: (1) Under the ecological intactness score range of 0–10, the GPNP with about 92.6% area of the EIS was above 6.0, and the mean baseline level of intactness was 7.1 when it was established in 2018. (2) The EIS in the east of Qionglaishan and south of Minshan were relatively lower than the rest of the study area. (3) During the past 40 years, 80% of the GPNP's ecological intactness has remained stable. (4) In total, 14% of the GPNP was degraded mainly in the areas below 1200 m with severe human activities. (5) LUCC and road construction were the main driving factors for the decrease of ecological intactness in the GPNP. (6) The habitat of the giant panda is mainly distributed in the areas with an EIS above 6.0, and this is a key link between ecological intactness and habitat suitability. Our research proved that the ecological intactness score (EIS) is an effective indicator for monitoring and assessing the impact of human activities on the regional natural ecosystem and could be helpful for ecological restoration and human activities management GPNP in the future. [ABSTRACT FROM AUTHOR]

Background and aims: Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING) are key components of the innate immune system. This study aims to evaluate the research of cGAS-STING pathway and predict the hotspots and developing trends in this field using bibliometric analysis. Methods: We retrieved publications from Science Citation Index Expanded (SCI-expanded) of Web of Science Core Collection (WoSCC) in 1975-2021 on 16 March 2022. We examined the retrieved data by bibliometrix package in R software, VOSviewer and CiteSpace were used for visualizing the trends and hotspots of research on the cGAS-STING pathway. Results: We identified 1047 original articles and reviews on the cGAS-STING pathway published between 1975 and 2021. Before 2016, the publication trend was increasing steadily, but there was a significant increase after 2016. The United States of America (USA) produced the highest number of papers (Np) and took the highest number of citations (Nc), followed by China and Germany. The University of Texas System and Frontiers in Immunology were the most prolific affiliation and journal respectively. In addition, collaboration network analysis showed that there were tight collaborations among the USA, China and some European countries, so the top 10 affiliations were all from these countries and regions. The paper published by Sun LJ in 2013 reached the highest local citation score (LCS). Keywords co-occurrence and co-citation cluster analysis revealed that inflammation, senescence, and tumor were popular terms related to the cGAS-STING pathway recently. Keywords burst detection suggested that STING-dependent innate immunity and NF-κB-dependent broad antiviral response were newly-emerged hotspots in this area. Conclusions: This bibliometric analysis shows that publications related to the cGAS-STING pathway tend to increase continuously. The research focus has shifted from the mechanism how cGAS senses dsDNA and cGAMP binds to STING to the roles of the cGAS-STING pathway in different pathological state. [ABSTRACT FROM AUTHOR]

In this study, the sedimentary records, sources, and ecological risks of polycyclic aromatic hydrocarbons (PAHs) in Dianchi Lake were analyzed. The concentrations of ΣPAH16 in the sediments of Dianchi Lake ranged from 368 to 990 ng/g, with an average value of 572 ng/g, peaking in 1988. Economic development, rapid population growth, and rapid growth of coal consumption have a greater impact on the HMW (high molecular weight) PAHs than on the LMW (low molecular weight) PAHs in the sedimentary environment. The results of the diagnostic ratios and PCA (principal component analysis) model show that the main sources of PAHs were coal and biomass combustion, as well as the fossil fuel combustion in individual years. The risk assessment results showed that the PAH concentrations in the sediment were within a safe range. In the past 100 years of sediment pore water, other 2–3 ring LMW PAHs were within a safe range (except for Phe, which reached chronic toxic pollution levels in some years). With an increase in industrialization and urbanization, the burning of fossil fuels such as coal and petroleum has increased, and some of the 4–6 ring HMW PAHs have reached chronic toxicity or even acute toxicity in the sediment pore water. [ABSTRACT FROM AUTHOR]

We examined the impacts of aerosol–radiation interactions, including the effects of aerosol–photolysis interaction (API) and aerosol–radiation feedback (ARF), on surface-layer ozone (O3) concentrations during four multi-pollutant air pollution episodes characterized by high O3 and PM2.5 levels during 28 July to 3 August 2014 (Episode1), 8–13 July 2015 (Episode2), 5–11 June 2016 (Episode3), and 28 June to 3 July 2017 (Episode4) in North China, by using the Weather Research and Forecasting with Chemistry (WRF-Chem) model embedded with an integrated process analysis scheme. Our results show that API and ARF reduced the daytime shortwave radiative fluxes at the surface by 92.4–102.9 Wm-2 and increased daytime shortwave radiative fluxes in the atmosphere by 72.8–85.2 Wm-2 , as the values were averaged over the complex air pollution areas (CAPAs) in each of the four episodes. As a result, the stabilized atmosphere decreased the daytime planetary boundary layer height and 10 m wind speed by 129.0–249.0 m and 0.05–0.15 ms-1 , respectively, in CAPAs in the four episodes. Aerosols were simulated to reduce the daytime near-surface photolysis rates of J[NO2] and J[O1D] by 1.8 × 10 -3 –2.0 × 10 -3 and 5.7 × 10 -6 –6.4 × 10 -6 s-1 , respectively, in CAPAs in the four episodes. All of the four episodes show the same conclusion, which is that the reduction in O3 by API is larger than that by ARF. API (ARF) was simulated to change daytime surface-layer O3 concentrations by - 8.5 ppb (parts per billion; - 2.9 ppb), - 10.3 ppb (- 1.0 ppb), - 9.1 ppb (- 0.9 ppb), and - 11.4 ppb (+ 0.7 ppb) in CAPAs of the four episodes, respectively. Process analysis indicated that the weakened O3 chemical production made the greatest contribution to API effect, while the reduced vertical mixing was the key process for ARF effect. Our conclusions suggest that future PM2.5 reductions may lead to O3 increases due to the weakened aerosol–radiation interactions, which should be considered in air quality planning. [ABSTRACT FROM AUTHOR]

• The sFlt1/PlGF ratio is a valuable biomarker for preeclampsia diagnosis. • A higher ratio than 85 could be used as an indicator for adverse outcomes. • Using PlGF levels to predict preeclampsia should start from 20 weeks of pregnancy. The soluble fms-like tyrosine kinase 1 (sFlt1)/placental growth factor (PlGF) ratio is a useful parameter for the diagnosis of preeclampsia. However, a comprehensive comparison of the ratio in preeclampsia and other hypertensive disorders of pregnancy was still missing and the dynamic levels of PlGF in the process of these diseases needed more clinical evidence. This retrospective study included participants tested for serum sFlt1 and PlGF levels at a national hospital in China throughout 2020. Diagnostic performance of the sFlt1/PlGF ratio and blood pressure was assessed by the receiver operating characteristic (ROC) analysis. The correlation of the sFlt1/PlGF ratio with pregnancy outcomes was evaluated using Kaplan-Meier curves. Besides, the circulating levels of PlGF were monitored in the time course of different hypertensive disorders' progress. The sFlt1/PlGF ratios were significantly elevated in the women with preeclampsia. The results of ROC analysis showed that, compared with blood pressure, the ratio is reliable for preeclampsia diagnosis from healthy control and shows better performance in distinguishing preeclampsia from other hypertensive disorders of pregnancy. A higher ratio than 85 could be used as an indicator of developing severe preeclampsia with adverse outcomes such as preterm delivery. Besides, our results suggested that using PlGF to predict preeclampsia should after 20 weeks of pregnancy. The PlGF and sFlt1/PlGF ratio are worth implementing in clinical management of women with preeclampsia rather than other hypertensive disorders of pregnancy. [ABSTRACT FROM AUTHOR]

[Display omitted] • Higher silica, K, and lower Al contents of musovites prove the involvement of shallow magmatic fluids. • High Mg-Ti contents of muscovites and core-rim variations of muscovites-beryls show the existence of deep magmatic fluids. • Be mineralization was achieved under the co-contribution of shallow magmatic fluids and deep magmatic fluids. Vein-type and greisen-type beryllium (Be) mineralization is closely associated with the magmatic-hydrothermal evolution in highly fractionated granites. However, the source of ore-forming fluids and their role in the migration and enrichment of Be is poorly understood. Although whole rock Ba-Rb isotope researches highlight that even deep magmatic fluids beneath the shallow magmatic-hydrothermal systems could provide rare metals and promote mineralization, it is still challenging to determine the influences of such fluids via using conventional geochemical indicators. Here we present zircon-monazite-xenotime-wolframite U-Pb ages, whole-rock geochemistry, monazite Nd isotopes, as well as muscovite and beryl geochemistry for the Zhujiayingzi quartz vein-type Be mineralization in the southern Great Xing'an Range (SGXR), Northeast (NE) China, and introduce the neighboring Nasigatu gresien-type Be mineralization for comparison. Geochronological results reveal that the Zhujiayingzi beryl-wolframite-bearing quartz veins formed in the Early Cretaceous (149–147 Ma), much younger than the host Permian (270–267 Ma) crystal tuffs, but coeval with the Nasigatu highly fractionated alkali-feldspar granite (144–139 Ma). Similar muscovite-beryl compositions and monazite Nd isotopes, combining with their close temporal-spatial relationships indicate that the Zhujiayingzi and Nasigatu Be mineralization have consistent hydrothermal assemblages and enrichment processes. Higher silica, K, and lower Al contents of muscovites from Be-rich veins (M2) and greisens (M4) than those recorded in barren crystal tuffs (M1) and alkali-feldspar granite samples (M3) at both Zhujiayingzi and Nasigatu are consistent with the evolution of the Early Cretaceous granitic magma, proving the involvement of shallow magmatic fluids exsolved from the Nasigatu-like highly evolved granitic melts. However, ore-related M2 and M4 samples have higher Mg (>1 wt%) and Ti contents than those of M1 and M3 samples, which violates the conventional hydrothermal evolution trend. Trace element compositions as well as K/Rb, K/Cs, and Rb/Sr ratios of four-type muscovites, together with the core-rim geochemical variations of muscovites at Zhujiayingzi and beryls at Nasigatu, indicate the existence of deep magmatic fluids rather than fluid-rock interaction to account for the anomalous mineralogical evidence. Such deep magmatic fluids were exsolved from large silicic magmatic reservoirs beneath the shallow magmatic-hydrothermal system, and thus likely display low evolution degrees and high Mg-Ti contents. They can not only provide heat and promote fluid-mineral interactions, but also can efficiently extract and transport Be enriched in deep crystal mushes at different depths. Thus we invoke that the Early Cretaceous Be mineralization in the SGXR was achieved under the combined action of both shallow and deep magmatic fluids derived from the crystal mush-dominated transcrustal magmatic system. [ABSTRACT FROM AUTHOR]

Rainwater harvested in cellars is widely used for domestic water supply in rural areas of Northwestern China to prevent water shortages. Microorganisms in rainwater harvesting cellar sediment (RHCS) are the driving force of elemental translocation and water purification in the rainwater cellar ecosystem. In this study, 16S-rRNA high-throughput gene sequencing and relevant analytical methods were used to explore the microbial community distribution, structure, function, and the influence of environmental factors of two different (cement and red clay) RHCS from peasant households in the arid and semi-arid regions of Northwestern China. Proteobacteria (γ-Proteobacteria) with Pseudomonadales (Pseudomonas) were the predominant microorganisms, playing an important role in the metabolism of amino acids, carbohydrates, lipids, cofactors and vitamins, nucleotides, and xenobiotics. Taxa with lower relative abundance were able to metabolize terpenoids, polyketides, glycans, and other amino acids, promoting biosynthesis of other secondary metabolites as well as glycans. In addition, enzyme families were identified. Most bacterial phyla were negatively correlated with nitrate nitrogen (NO 3 --N), total nitrogen (TN), and organic matter, while ammonia nitrogen (NH 4 +-N) and total phosphorus (TP) were positively correlated with corresponding dominant microbial genera. Nearly all taxa were negatively correlated with TN. Strong functional associations existed between most microorganisms. This study provides a basis for the understanding of microbial community structures and relationships, as well as their relationships with environmental factors in RHCS. To improve rainwater quality, non-point pollution management and control methods are necessary, such as keeping the rainwater harvesting surface clean, discarding initial rainwater runoff, and guiding the rainwater flow path. [Display omitted] • This study fills the gap in the research field of sediment microorganisms of relatively closed and small-scale water bodies. • This study presents the most classic species abundance distribution pattern in ecology. • This study provide scientific foundation for the purification and utilization of rainwater harvested in cellar. [ABSTRACT FROM AUTHOR]

In the dual context of global aging and the cleaner energy transition, the impact of home-based care for the aged on cooking energy preferences in rural areas is important. This paper selects CHARLS 2018 data, uses the Probit model, and constructs a theoretical framework with Fogg's Behavior Model to demonstrate the effects of care for the aged. The results showed that older persons with family care in rural areas were more likely to use traditional cooking energy. The disincentive is reinforced by the utilization of traditional cooking energy by neighbors in the community. And those with personal care were more likely to use clean cooking energy. The ability to guarantee clean cooking energy being adopted reinforces the facilitating effect of personal care. In order to promote and use clean energy, it is vital to understand the unique influence of different kinds of care for the aged. Efforts in policy and practice should focus on boosting the motivation and ability to adopt clean energy. The main contributions are: (1) The paper included different kinds of care for the aged as an influencing factor in using clean cooking energy; (2) Through its analysis of motivation and ability factors influencing behavioral choices, it exhaustively explores the inherent mechanisms; (3) This paper can bring policy implications for the promotion of clean cooking energy in rural areas of developing countries. • Family care for the aged inhibits the choice of clean cooking energy, while personal care promotes the usage. • The neighborhood effect and feasible ability can regulate the influence of the two kinds of care respectively. • Fogg's Behavior Model Provides a whole new research framework. • Enhancing motivation and feasible ability can promote clean cooking energy in developing countries' rural areas. [ABSTRACT FROM AUTHOR]

Oesophageal squamous cell carcinoma (ESCC) remains a clinically challenging disease with high morbidity rates and poor prognosis. ESCC is also the most common pathological type of oesophageal cancer (EC) in China. Ras-related genes are one of the most frequently mutated gene families in cancer and regulate tumour development and progression. Given this, we investigated the Ras-related gene expression profiles and their values in ESCC prognosis, using data from the Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) databases. We found that we could identify three distinct oesophageal cancer clusters based on their unique expression profile for 11 differentially expressed Ras-related genes with each of these demonstrating some prognostic value when, evaluated using univariate Cox analysis. We then used multivariate Cox analysis to identify relevant independent prognostic indicators and used these to build a new prognostic prediction model for oesophageal cancer patients using these three Ras-related genes. These evaluations produced an area under the curve (AUC) of 0.932. We found that our Ras-related signatures could also act as independent factors in ESCC prognosis and that patients with low Ras scores showed a higher overall expression levels of various immune checkpoint genes, including TNFSF4, TNFRSF8, TNFRSF9, NRP1, CD28, CD70, CD200, CD276, METTL16, METTL14, ZC3H13, YTHDF3, VIRMA, FTO, and RBM15, as well as a higher CSMD3, FLG, DNAH5, MUC4, PLCO, EYS, and ZNF804B mutation rates, and better sensitivity to drugs such as erlotinib, paclitaxel, and gefitinib. In conclusion, we were able to use the unique expression profiles of several Ras-related genes to produce a novel disease signature which might facilitate improved prognosis in ESCC, providing new insight into both diagnosis and treatment in these cancers. [ABSTRACT FROM AUTHOR]

There is a broad consensus that subduction of the Paleo-Pacific oceanic plate has caused extensive magmatism, lithospheric deformation, and metal mineralization in the eastern margin of the Eurasian continent during the Late Mesozoic. However, the onset and extent of subduction of the Paleo-Pacific Ocean, especially the timing of the transition in tectonic regime from the Paleo-Asian Ocean to Paleo-Pacific, and extent of the subduction of the Paleo-Pacific Ocean remain poorly constrained. To address these key issues, we present regional geological observations, zircon U–Pb dating, whole-rock geochemistry, and Hf isotopic compositions of the Jurassic intrusions at the northern margin of the North China Craton, with the aim of constraining their petrogenesis and the tectono-magmatic events related to subduction of the Paleo-Pacific Ocean. The geochronological and geochemical results indicate that these intrusions were emplaced between 177 and 155 Ma, with distinct geochemical features. The Huajianggou pluton (HJG), Tongjiatun pluton (TJT), and Haoguantun pluton (HGT) are characterized by high Al2O3 and Sr contents, and low MgO, TFe2O3, Y, Yb, and heavy rare earth elements (HREEs) contents, coupled with high Sr/Y values (34.10–94.36), showing adakitic affinities. Based on these geochemical characteristics, we suggest that these adakitic magmas (i.e. the HJG, TJT, and HGT plutons) were produced by partial melting of thickened lower crust in response to earlier subduction of the Paleo-Pacific oceanic plate beneath the northern margin of the North China Craton. In contrast, the Baijiagou pluton (BJG) and Sheshangou pluton (SSG) are high-K calc-alkaline rocks with low Sr/Y ratios (0.80–17.77), and they exhibit petrological and geochemical characteristics of I-type granites, indicating an origin from the lower crust, with variable degrees of fractional crystallization. In addition, the Bakeshu pluton (BKS) is mainly comprised of diorite that displays high SiO2, low MgO, Cr, and Ni contents, with Mg# of 39.8–42.9, indicating a lower crustal origin. Despite the range in ages of these intrusions, all the Jurassic calc-alkaline intrusions show typical geochemical characteristics of active continental margins, such as enrichment in large ion lithophile elements (LILEs) and light rare earth elements (LREEs), and depletion in high field strength elements (HFSEs). Combined with spatial-temporal variations of coeval magmatic rocks along the northern margin of the North China Craton, we suggest that the transition in tectonic regime from the Paleo-Asian Ocean to Paleo-Pacific Ocean was initiated in the Early Jurassic. These Jurassic intrusions formed in an active continental margin setting, related to westward subduction of the Paleo-Pacific oceanic plate. Importantly, the Early Jurassic subduction-related calc-alkaline magmatic rocks in northeast (NE) China constitute a NE-trending magmatic arc belt, which is best explained as continental magmatism triggered by the westward subduction of the Paleo-Pacific oceanic plate. [ABSTRACT FROM AUTHOR]

We present detailed geochronological, geochemical, and zircon Hf isotopic data for Late Paleozoic granitic rocks from Handagai and Zhonghe plutons in the Xing'an Block, NE China, aiming to provide constraints on their origin and tectonic implications. New zircon U−Pb ages indicate they were formed in the Late Devonian (ca. 379 Ma) immediately after a striking 50 Ma magmatic lull (ca. 430–380 Ma) in the Xing'an Block. Petrological and geochemical features suggest that the Handagai monzogranites and Zhonghe alkali-feldspar granites are I- and A-type granites, respectively, although both of them have high-K calc-alkaline features and positive zircon εHf(t) values (+3.47 to +10.77). We infer that the Handagai monzogranites were produced by partial melting of juvenile basaltic crustal materials under a pressure of <8–10 kbar, whereas the Zhonghe alkali-feldspar granites were generated by partial melting of juvenile felsic crustal materials at shallower depths (P ⩽4 kbar). Our results, together with published regional data, indicate their generation involves a subduction-related extensional setting. Slab break-off of the Hegenshan-Heihe oceanic plate may account for the subduction-related extensional setting, as well as the transformation of arc magmatism from the Early-Middle Devonian lull to the Late Devonian-Early Carboniferous flare-up in the Xing'an Block. [ABSTRACT FROM AUTHOR]

The northern margin of the North China Craton (NCC) contains widespread Permian magmatic rocks, but the origin of these rocks remains controversial. This uncertainty hampers us from better understanding of tectonic framework and evolution of the eastern Paleo‐Asian Ocean, particularly with respect to its final‐stage subduction and closure time. To address these questions, this study presents petrological, zircon U‐Pb geochronological, whole‐rock geochemical and in situ zircon Hf isotopic data for these Permian mafic intrusions in the northern margin of the NCC. Precise zircon U‐Pb dating results indicate that these mafic intrusions were emplaced in the Middle Permian (ca. 260 Ma). Geochemically, the studied mafic intrusions have high MgO and transition metals element contents, with high Mg# values, indicating a mantle origin. These mafic intrusions are characterized by enrichments in large ion lithophile elements (LILEs; e.g., Rb, Ba, and K) and light rare earth elements (LREEs), and depletions in high field strength elements (HFSEs; e.g., Nb, Ta, and Ti) and heavy rare earth elements (HREEs), indicating that they were formed in a subduction‐related setting. These geochemical features, together with zircon ∊Hf(t) values (–1.1 to +11.2), indicate that their parental magmas were derived from partial melting of heterogeneous mantle wedge metasomatized by subduction‐related fluids, with the contributions of slab sediments. The studied mafic intrusions also show wide range of major and trace elements contents, and variable Mg# values, Eu and Sr anomalies, suggesting that their parental magmas had undergone variable degrees of fractional crystallization. Together with the E–W trending Permian continental arc along the northern margin of the NCC, we confirm that the generation of the Middle Permian mafic intrusions was related to southward subduction of the Paleo‐Asian oceanic lithosphere beneath the NCC and the Paleo‐Asian Ocean had not closed prior to the Middle Permian. [ABSTRACT FROM AUTHOR]

An analysis of the correlation between polycyclic aromatic hydrocarbons (PAHs) and economic parameters demonstrates that the total population, gross domestic product, coal consumption, petroleum, temperature, and day consumption significantly affect PAH concentrations in Dianchi Lake, Yunnan province, China. An artificial neural network (ANN) model was developed to predict the trend in PAH concentrations in the sediments of Dianchi Lake over the next 10 years based on current indicators of economic development. The ANN model estimated the concentration of PAHs from 1980 to 2014. The model was evaluated using available observations for the historical trends; concentrations of PAHs in the sediments of Dianchi Lake are calculated to be at 2128.1 ng/g in 2025 and are expected to decline up to 1044.3 ng/g by 2030. These concentrations are considered relatively high because of their impacts on the health of people and aquatic organisms and the development of surrounding industries. We show the importance of the socioeconomic and climate factors in increasing the pollution levels. Our results could support the local government to formulate effective measures to reduce the pollution levels in the lake. [ABSTRACT FROM AUTHOR]