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Coal mine goafs can be used to store and purify mine water; therefore, they are important for mitigating the environmental impact of mining on ecologically fragile areas in Western China. Coal gangue in goafs can reduce turbidity, suspended matter, total hardness, and chemical oxygen demand (COD) in mine wastewater. Because gangue in goaf areas is rich in clay minerals, they serve as ion exchange sites. We investigated the adsorption of heavy metal ions by silty mudstones in the Ulan Mulun mine. The adsorption kinetics and isothermal adsorption characteristics of four heavy metal ions, i.e., Pb(II), Cd(II), Cr(III), and Mn(II), were investigated using batch experiments. Under a pH of 6.75 and temperature of 20°C, the adsorption capacity of silty mudstone particles (<74 μm) was 6.3012 g, 1.5701, 1.2571, and 1.3729 mg/g for Pb(II), Cd(II), Cr(III), and Mn(II), respectively. Based on the experimental results, quantitative relationships between the adsorption quantity per unit of rock surface and the equilibrium concentration of heavy metals in solution were developed using Langmuir, Freundlich, and D–R equations. The relationships were used to obtain the equilibrium concentration of the solution. Finally, the ratio of the f value of the water-rock contact area in the goaf to the water volume was calculated and analyzed. The f value was inversely proportional to the average vertical opening of gaps between gangues in the goaf. The adsorption rate functions for Pb(II), Cd(II), Cr(III), and Mn(II) in the goaf were obtained, and the corresponding adsorption capacities were calculated. The adsorption capacities were controlled by the f value and adsorption properties of the gangue. These results can be used in future studies on mine wastewater treatment. [ABSTRACT FROM AUTHOR]

The Holocene hydrological regime on the Heixiazi Island is critical for understanding the evolution of the East Asian summer monsoon (EASM) for the island's climate-sensitive location on the northern fringe of the EASM domain. In this paper, a marsh depression on the central island was selected to reconstruct the locally hydrological variation and to discuss its indications for the Holocene EASM evolution. This work is based on multi-proxy (magnetic susceptibility, grain size, loss-on-ignition, and carbonate content) analyses of 22 modern sedimentary samples with a water-level gradient of 0–66 cm and 100 cored sedimentary samples covering last ~ 9.0 ka BP. The proxies' hydrological significance was previously interpreted by the 22 modern samples using linear regression equations to construct their relationships to water-level changes. Among these proxies, the magnetic susceptibility, carbonate content, as well as the Md and sand fraction of grain size exhibit high-level relationships against the water-level changes with R2 > 0.6. Thus, these four proxies' linear-regression equations were selected and used on the 100 cored samples, and the Holocene water-level changes in the studied depression were quantitatively reconstructed. It shows that two relatively high water-level stages with strengthened EASM occurred during 8.0–4.5 ka BP and 3.0–1.4 ka BP, which were alternated by three low water-level stages with declined EASM during ~ 9.0–8.0 ka BP, 4.5–3.0 ka BP, and 1.4–0 ka BP, respectively. Among these fluctuations, the highest water-level stage with most strengthened EASM which is defined as the Holocene Monsoon Maximum occurred during 6.4–4.5 ka BP. Such a new evolution pattern of the EASM can be further supported by a large variety of records from monsoon-margin regions. We suggest the Holocene EASM evolution was generally associated with the thermal conditions in both the inner Eurasia landmass and the West Pacific Ocean, with an exception of the weak EASM before 8.0 ka BP due to the enhanced Siberia High with the dominance of the Eurasia ice sheet in the early Holocene. [ABSTRACT FROM AUTHOR]

Based on 57 literatures, the quantitative relations among the apparent activation energy, E, apparent pre-exponential factor, k0 and volatile content on dry ash free basis, Vdaf, fuel ratio (FR) data from TGA experiments were obtained for 131 Chinese power coal samples. Regression was made for lg k0, E with Vdaf, FR, the regression results show that ① E, lg k0 decrease linearly with Vdaf, E = 109. 6-0. 365Vdaf lg k0 = 5. 406-0. 04 Vdaf, and lg k0 increases linearly with E, lg k0 = -0. 193+0. 043E. According to Vdaf of Chinese power coals, E and k0 can be calculated. In addition, according to Arrhenius Law, reaction speed constant number during power coal burning processes can be calculated. ② with the increase of FR, E and lg k0 increase with FR generally, E = 90. 891 +3. 097 37FR-0. 138FR², lg k0 = 3.413 2 - 0. 001FR+0. 022 8FR² The two mathematic relationships mentioned above correspond to the relationship of lg k0 increasing linearly with E. [ABSTRACT FROM AUTHOR]

Schematic figure showing climate driving mechanisms on wetland hydrological and vegetational evolution. The relatively strong East Asian summer monsoon (EASM) with high precipitation tends to generate a higher water-level condition with more hygrophilous herbaceous plants while blocking the deposition of coarse grain-size fractions (a), and vise versa for weak EASM stages (b). [Display omitted] • The late-Holocene hydrological and vegetational regimes were reconstructed. • An ecological lake-to-wetland transition occurred at ~4.5 ka BP. • The wetlands evolution was largely controlled by monsoonal precipitation. The responding mechanism of wetland ecosystem to climate change is currently unclear due to a lack of long-term records incorporating multiple ecological factors. This paper presents a well-dated and multi-proxy cored record from a natural freshwater wetland developed in a paleo-pingo-related depression on the Sanjiang Plain. The study aims to reconstruct the wetland water-level and vegetational regimes during the past ~6.0 ka BP and discuss the wetland evolution response to the East Asian summer monsoon (EASM) circulation. The results show that a shallow-water lake with hygrophilous herbs developed in the depression with a strong EASM during ~6.0–4.5 ka BP. The paleolake was succeeded by a wetland with a lowered mean water level and an increase in tree cover controlled by the weakened EASM during the past 4.5 ka BP. Such an ecological lake-to-wetland transition corresponds well to the sharp decline of the EASM around 4.5 ka BP which has been well documented in various geological records across the EASM domain. During the wetland developing stage over the past 4.5 ka BP, the water-level and vegetational changes in the studied depression were also closely related to the EASM variations. The strengthened EASM usually generated higher water levels with more hygrophilous herbs around 4.0 ka BP, 3.5 ka BP, 3.0 ka BP, 2.0 ka BP, and 1.3 ka BP. Considering the prevalent EASM climate serving as the predominant water supply for the wetlands on the modern Sanjiang Plain, we suggest the EASM circulation has played a critical role in driving the wetland ecological evolution during the mid-to-late Holocene Epoch. The past 0.4 ka BP is an exception as the local Trees/Herbs ratio visibly increased with the declined water level, while the monsoonal precipitation shows no equivalent shift. The wetland evolution at this stage was attributed to human interference. [ABSTRACT FROM AUTHOR]

Backgrounds: The EuroQol Group Five-Dimensional (EQ-5D) instruments have been validated in China for measuring health-related quality of life (HRQoL) and are increasingly being used in health economic studies. However, there is paucity in the literature documenting long-term changes in the EQ-5D results in the Chinese populations. This study aims to identify such changes and their determinants using the EQ-5D-3 L instrument.Methods: Data were obtained from the National Health Services Surveys in China, which included the EQ-5D-3 L since 2008. We compared the differences between the 2008 and 2013 surveys in the percentage of reported problems, visual analogue scale (VAS) scores, and the EQ-5D-3 L utility index derived from the national value sets. Factors associated with population changes in these EQ-5D results were identified using logistic, linear and Tobit regression models, respectively.Results: Compared with 2008, reported problems in self-care (3.3% vs 3.1%), usual activities (4.8% vs 4.6%) and anxiety/depression (6.4% vs 5.3%) decreased, whereas reported problems in mobility (5.1% vs 5.9%) and pain/discomfort (9.3% vs 12.6%) increased significantly (p < 0.05) in 2013. The regression models revealed a rise (β = 1.61, p < 0.001) in VAS scores, but a slight drop (β = - 0.01, p < 0.001) in utility index in 2013 compared with 2008 after controlling for variations in demographic, behavioral, socioeconomic and residential variables. But the effect sizes of the changes over time (estimated by "average change divided by baseline standard deviation") did not reach the threshold of clinical importance after adjustment for variations in other factors. Higher socioeconomic status (in terms of education, income and residential location) was associated with better EQ-5D-3 L results.Conclusion: The changing trend (decrease) of the utility index is contradictory to that (increase) of the VAS scores, although neither is deemed clinically important. It is evident that socioeconomic and regional disparities in HRQoL exist in China. [ABSTRACT FROM AUTHOR]

Background: After the elimination of leprosy in 1995, there were 10–30 newly detected leprosy cases every year in Zhejiang Province, and the epidemiological characteristics of the newly detected leprosy cases have changed. While most of the newly detected cases came from other provinces in China, not Zhejiang, it brought a new challenge for leprosy prevention and control in post- elimination era in Zhejiang, China. This study was aimed to understand the temporal-spatial distribution characteristics of newly detected leprosy cases, and provide the scientific rationales for the development of leprosy control strategy. Methods: Data on the demographic of Zhejiang Province from 2011 to 2019 were obtained from the China Information System for Disease Control and Prevention, and the epidemiological data on leprosy cases newly detected in Zhejiang Province from 2011 to 2019 were obtained from the LEPROSY MANAGEMANT INFORMATION SYSTEM IN CHINA (LEPMIS), and temporal-spatial distributions were described. The geographic information system software—ArcGIS 10.4 was used to draw the statistical maps, and Geoda 1.14.0 was used for local spatial autocorrelation analysis (local Getis coefficient method). Ridley-Jopling classification was used to classify the clinical types into I, TT, BT, BB, BL or LL. Two-group classification system developed by the World Health Organization (WHO) was used and cases were classified into multibacillary (MB) type or paucibacillary (PB) type. Results: A total of 167 leprosy cases were reported in Zhejiang Province during 2011–2019, including 107 cases in males and 60 in females. The mean age at diagnosis was 37.99±14.81 years, and 94.01% of the cases were detected through the examination at skin-clinics. The number of workers, MB cases, G2D cases were 81 (48.50%), 159 (94.01%), 24 (14.37%) respectively, and the rate of early detection increased from 45.16% in 2011 to 90.91% in 2019. Leprosy cases were reported in all the prefectures of Zhejiang except Zhoushan City. The cases in local population accounted for 23.35% (39 cases), and the cases in floating population (especially coming from high epidemic provinces in China) accounted for 76.65% (128 cases). The annual number of newly detected cases showed a decreasing trend, from 31 cases in 2011 to 11 in 2019. Time of the floating population living in Zhejiang Province ranged from several months to more than 10 years. The annual proportion of new cases with G2D declined from 22.58% in 2011 to 9.09% in 2019. The results of local indicators of autocorrelation (LISA) analysis showed that the high-high areas were mainly concentrated in the middle and northeast of Zhejiang Province, while the low-low areas were in the east and southwest. Conclusion: A few scattered cases still can be seen in post-elimination era, and there was a spatial clustering of the newly detected leprosy cases in Zhejiang Province. Most of the cases in Zhejiang Province were from other high epidemic provinces in China, which brought a new challenge for leprosy control and prevention in post- elimination era in Zhejiang, and it is also necessary to strengthen the early detection and standard management of the leprosy cases in floating population in Zhejiang. Author summary: After elimination, most of the leprosy cases were detected passively, and the epidemiological characteristics of the newly detected leprosy cases had been changed. The proportion of floating population from other provinces in China increased year by year. In 2011, Health Commission of Zhejiang Province developed the planning of reducing harm of leprosy (2011–2020) and implemented leprosy symptom monitoring system in order to strengthen the early detection of leprosy cases. 167 newly detected cases during 2011–2019 were analyzed, whose factors were associated with household registration of other provinces, G2D and delay in diagnosis were explored. Annual proportion of household registration of other provinces showed an increasing trend, from 77.42% in 2011 to 81.82% in 2019, while G2D and delay in diagnosis among newly detected cases showed declining trends, from 22.58%, 40 months in 2011 to 9.09%, 11 months in 2019 respectively. In late phase of leprosy control, some kinds of leprosy control program are still necessary. Control and prevention strategy of floating population based on government commitments would be beneficial to improve early detection of leprosy cases. [ABSTRACT FROM AUTHOR]

Vibrio vulnificus is a pathogenic bacterium that causes disease in marine fish, affecting fish farming and human health worldwide. In May 2021, in the Bohai Bay region, a disease broke out in commercially farmed pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus), causing huge economic losses. The diseased fish had skin lesions, water accumulation in their abdomens, and showed tissue and organ damage. V. vulnificus biotype 2 has been reported in eels and other marine fish, but it is less reported in pearl gentian grouper. In this study, the pathogenic strain isolated from diseased fish was identified as V. vulnificus EPL 0201 biotype 2 on the basis of physiological and biochemical characteristics and the results of 16S rRNA gene and gyrB sequencing, virulence gene detection, and recursive infection experiments. To gain a comprehensive understanding of the pathogenicity and drug resistance of this strain, whole-genome sequencing was performed. Whole-genome analysis showed that the gene map of this strain was complete. The Virulence Factor Database annotation results showed that this strain had the key virulence factor genes vvhA and rtxA, which cause host disease. In addition, this strain had genes conferring resistance against cephalosporins, aminoglycosides, tetracyclines, and sulfonamides. Antimicrobial susceptibility testing confirmed the presence of these resistance genes identified in the genome. The results of this study show that V. vulnificus EPL 0201 biotype 2 is a multi-drug resistant strain with high pathogenicity. [ABSTRACT FROM AUTHOR]

A new derivation of the three-dimensional (3D) limit equilibrium method for slope stability analyses is presented, which applies linear algebra operations to matrices to achieve a highly efficient algorithm while maintaining the rigorousness of the formulation. It satisfies six equilibrium conditions and includes all of the components of the intercolumnar forces. The generalized 3D Morgenstern-Price's (MP) assumption for the intercolumn forces is recast into incremental forms. The advantage is that the unknowns of the different physical meanings (i.e., factor of safety (FS) and the coefficients in the MP assumption) are determined by balancing the forces and moments independently. Along with the recasting correction coefficients, they are solved with the triple nested algorithm. The numerical instability that is related to the different orders of magnitude for the residuals is avoided. The varication examples show: (i) the insensitivity of the FS to the prescribed functions in the MP assumption, (ii) the reliability of the method to cope with a complicated slope geometry (simplified methods may provide a larger FS for certain cases), and (iii) the superior efficiency of the algorithm (requires several seconds to converge). This study proposes a practical way to track the irregular 3D tension cracking by repeating the analysis and excluding the columns with the negative normal forces at the bottom. This formulation is applied to a valley landfill slope in China. In comparison to the two-dimensional analysis, there are more reasonable/cost-effective measures to increase the system stability through 3D analyses for several conditions (e.g., seismic loading). • A new three-dimensional method is devised by concise linear algebra operations. • It considers 6 equilibrium conditions and all intercolumnar force components. • Triple nested algorithm achieves a high-efficiency and a good convergence. • Factor of safety is insensitive to the intercolumn force distribution function. • A practical way is proposed to track highly irregular tension cracking surface. [ABSTRACT FROM AUTHOR]

Background: Continuous renal replacement therapy (CRRT) and other extracorporeal therapies for acute kidney injury (AKI) and other organ dysfunction syndromes in critically ill patients are common in the intensive care unit (ICU). Many studies have focused on clinical practice for managing these conditions. However, there are few studies that describe the utilization of extracorporeal therapies, especially CRRT, in patients with sepsis-associated AKI. Summary: Two hundred ICU physicians were included in a survey from February 28, 2017, to March 20, 2017, on the current status of septic AKI and clinical practice in CRRT. According to the responses, 40% of sepsis patients in the ICU had AKI, and 25% required extracorporeal therapies. However, 29% of candidates gave up therapy for medical or nonmedical reasons. Overall survival for sepsis was 60%; among survivors, 80% were dialysis free at discharge. CRRT was the most common modality of extracorporeal therapy in the ICU, and 82% of physicians chose convection as the major clearance mode. The survey showed 30% of physicians saw the removal of inflammatory mediators as the major objective of extracorporeal therapies; however, only 18.5% of physicians considered inflammation as a measure to trigger CRRT. The median treatment duration of CRRT in China was 12 h per day for 5 days. Key Messages: There were some similarities and differences in CRRT practice for septic AKI patients in China and globally. The differences reveal some insights into improving the outcomes of these patients. [ABSTRACT FROM AUTHOR]

Background: oXiris is a blood purification product that has been launched recently in China. In addition to renal function support and fluid management capabilities, it can also adsorb cytokines and endotoxins. This may complement standard treatment for septic acute kidney injury (AKI) patients to control the amplitude of systemic inflammatory response responsible for acute tissue and organ damage. Objectives of our study are to elucidate characteristics of septic AKI patients who respond to treatment with oXiris and to describe the performance of oXiris through patient cases in the absence of large randomized trials on clinical use of oXiris for septic AKI patients in China. Summary: Here, we present 4 cases managed in intensive care units of major hospitals in China. Key practical aspects from an expert meeting discussing these cases have been included as guidance for the use of oXiris in septic AKI patients. Key Messages: Based on the experience gathered from 4 cases, oXiris should be used early in the treatment of septic AKI patients as an adjuvant therapy with good infection source control. It should not be used to delay or replace infection source control. These cases also demonstrated that patients with high risk of bleeding can use oXiris without additional anticoagulation for up to 36 h without implications on serum protein levels and platelet count. Short of definitive biomarkers to gauge the ideal blood purification initiation and discontinuation time for septic AKI patients, clinical judgment is key to determining optimal use of oXiris in septic AKI patients. [ABSTRACT FROM AUTHOR]

The environmental impacts of grid-connected photovoltaic (PV) power generation from crystalline silicon (c-Si) solar modules in China have been investigated using life cycle assessment (LCA). The life cycle inventory was first analyzed. Then the energy consumption and greenhouse gas (GHG) emission during every process were estimated in detail, and finally the life-cycle value was calculated. The results showed that the energy payback time ( T EPBT ) of grid-connected PV power with crystalline silicon solar modules ranges from 1.6 to 2.3 years, while the GHG emissions now range from 60.1 to 87.3 g-CO 2 ,eq/kW h depending on the installation methods. About 84% or even more of the total energy consumption and total GHG emission occupied during the PV manufacturing process. The solar grade silicon (SoG-Si) production is the most energy-consuming and GHG-emitting process, which accounts for more than 35% of the total energy consumption and the total GHG emission. The results presented in this study are expected to provide useful information to enact reasonable policies, development targets, as well as subsidies for PV technology in China. [ABSTRACT FROM AUTHOR]

Highlights: [•] China’s PV industry’s development history and status quo were introduced. [•] The existing problems and challenges were analyzed based on field studies. [•] Policy recommendations and possible implementation incentives were provided. [ABSTRACT FROM AUTHOR]

Abstract: A new concept of ‘low-carbon towns’ (LCTs) has emerged in the urban planning and development of China in recent years to face the challenge of global climate change. This manuscript presents the current status, basic concepts, and town practices for the development of LCTs in China. First, we summarize the driving forces and regional activities for the development of LCTs in China; then, we introduce the town types and related programs. We propose the definition of a Chinese LCT and the main approaches to developing Chinese LCTs through a system analysis revealing what they are and how they may be developed in a Chinese context. The proposed approaches to develop Chinese LCTs include economic, social, layout, technology, and reuse approaches, each of which is introduced in the context of typical town planning and management in China. [Copyright &y& Elsevier]

Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most devastating diseases in wheat. Due to the large-scale and widely-distributed planting pattern of wheat, the directional selection pressure of the pathogen is very strong. Therefore, it is urgent to pyramid more stripe rust resistance genes in wheat cultivars to enhance resistance durability and ensure wheat production safety. In this study, two quantitative trait loci (QTL) for adult plant resistance (APR) to stripe rust, QYr.nafu-2BL and QYr.nafu-3BS, were validated and introgressed from wheat line P9897 into three Chinese elite wheat cultivars, Chuanmai 42, Xiangmai 25, and Zhengmai 9023, through marker validation. The three Chinese elite varieties were used as the female parent to cross with wheat line P9897, and they were selfed to the F6 generation. A total of 114 lines were then selected based on field agronomic traits and stripe rust resistance. Four markers (Xcfd73, Xgwm120, Xbarc87 and Xbarc133) linked with the QTL's regions were employed to screen the 114 F6 lines. Subsequently, 27 lines combining two target QTL from P9897 were selected. The combination of agronomic traits and disease resistance results showed that 13 of these selected lines had favorable application prospects. The promising lines selected in this study could enrich the genetic resources of wheat stripe rust resistance genes, as well as provide material support and a theoretical basis for the prevention and control of wheat stripe rust in China. [ABSTRACT FROM AUTHOR]

• Clay minerals promote LTO with larger O 2 consumption and COx release. • The yield of coke increased and that of produced oil decreased by montmorillonite. • The composition and properties of coke are obviously changed by clay minerals. • The compositions of produced oil and hydrocarbons remain nearly unchanged. • The mechanism how the clay minerals affect the LTO of heavy oil is analyzed. In situ combustion (ISC) is an efficient method to recover heavy oil, in which low-temperature oxidation (LTO) is an important process. A fixed-bed reactor was used to conduct ramped temperature oxidation experiments on a mixture of heavy oil from China, silica and clay minerals, including montmorillonite, kaolinite, illite and chlorite. The four clay minerals promoted the LTO of heavy oil, which was reflected in the increase in the total amount of O 2 consumption with the decrease in the peak temperature and the change in the composition and yield of gas, liquid and solid products. The total amounts of CO and CO 2 release increased, and the peak temperature decreased. The total amount of hydrocarbons in the gas phase decreased, whereas the peak temperature and main components didn't change. The presence of clay minerals showed little effect on the composition of produced oil, whereas the presence of montmorillonite decreased the yield of produced oil. The yield and O/C ratio of coke increased, the heat value of coke decreased and the oxidation activity of coke improved in the presence of clay minerals. Montmorillonite showed the most notable effect. The mechanism of the effects of clay minerals on the LTO of heavy oil was analyzed by combining the change in the distribution proportion of O and C in products. Montmorillonite had large specific surface area and adsorption capacity and catalyzed decarbonylation, decarboxylation and polycondensation. The other three clay minerals mainly affected the LTO of heavy oil through the catalysis of decarbonylation, decarboxylation and polycondensation. [ABSTRACT FROM AUTHOR]