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Word semantic knowledge (WSK) is crucial to the development of one's reading comprehension ability. A total of 608 students (208 poor readers in the experimental group and 200 poor readers in the control group one, and 200 typical readers in control group 2) from grade 4 participated in this study. Selected reading ability assessments were administered at pretest, post-test and a 3-month delayed post-test. After 6 weeks of intervention, poor readers from the experimental group scored higher in Chinese reading abilities than the poor readers in control group one. Experimental group students reached a similar level of reading abilities with typical readers. Findings from this study suggested the main challenge in reading activities for those students who had reading problems is the characters' semantic identification. The current study confirmed the self-agency learning mode is an effective approach to semantic intervention design on semantic network construction for primary school learners.

Background: Cognitive impairment (CI) is common in older adults, especially those with renal dysfunction. We aimed to investigate the complex relationships among renal function, nutritional status, and CI in older people free from late chronic kidney disease (CKD) and severe CI. Methods: A study of older people (≥60 years old) with an estimated glomerular filtration rate (eGFR) of >30 mL/min/1.73 m2 and Montreal Cognitive Assessment (MoCA) scores of >10 (n = 237) was conducted at Beijing Tongren Hospital. Their eGFR was determined using the CKD‐EPI‐cr‐Cysc equation. Cognitive function was evaluated with the MoCA. We tested the relationship between eGFR and MoCA scores using Spearman correlation analysis and multivariate logistic regression analysis. We then conducted a mediation analysis to figure out the mediating roles of nutritional indicators (Mini Nutritional Assessment‐Short Form (MNA‐SF) scores, albumin (ALB), and haemoglobin (HGB)) between the eGFR and MoCA scores. Results: The incidence of CI was 48.5% (115/237) in older people. Spearman correlation analysis revealed that the better the kidney function, the better the cognitive function (R = 0.297, P < 0.001). Multivariate logistic regression analysis revealed that eGFR decrease per 15 mL/min/1.73 m2 (OR: 1.415, 95% confidence interval: 1.055–1.896, P = 0.020) was related to CI after adjusting for age and sex. However, the eGFR was not associated with cognitive decline after adjusting for nutritional indicators, behavioural risk factors, other biomarkers, and chronic conditions, suggesting that eGFR is not independently associated with CI. Mediation analysis revealed that the MNA‐SF scores (a*b = 0.006 (0.0002–0.012)) and HGB (a*b = 0.008 (0.001–0.017)) were mediating factors between the eGFR and MoCA scores. Conclusions: A decline in renal function can directly lead to CI and can also exacerbate cognitive deficits through intermediary factors such as MNA‐SF scores and HGB. Therefore, correcting anaemia and improving nutritional status are significantly important for enhancing cognitive function in older patients, especially those with renal dysfunction. [ABSTRACT FROM AUTHOR]

Background: Rifampicin-resistant pulmonary tuberculosis (RR-PTB) presents a significant threat to global public health security. China bears a substantial burden of RR-PTB cases globally, with Guizhou Province experiencing particularly alarming trends, marked by a continual increase in patient numbers. Understanding the population characteristics and treatment modalities for RR-PTB is crucial for mitigating morbidity and mortality associated with this disease. Methods: We gathered epidemiological, diagnostic, and treatment data of all RR-PTB cases recorded in Guizhou Province from January 1, 2017 to December 31, 2023. Utilizing composition ratios as the analytical metric, we employed Chi-square tests to examine the spatiotemporal distribution patterns of RR-PTB patients and the evolving trends among different patient classifications over the study period. Results: In our study, 3396 cases of RR-PTB were analyzed, with an average age of 45 years. The number of RR-PTB patients rose significantly from 176 in 2017 to 960 in 2023, peaking notably among individuals aged 23–28 and 44–54, with a rising proportion in the 51–80 age group (P < 0.001). Since 2021, there has been a notable increase in the proportion of female patients. While individuals of Han ethnic group comprised the largest group, their proportion decreased over time (P < 0.001). Conversely, the Miao ethnicity showed an increasing trend (P < 0.05). The majority of patients were farmers, with their proportion showing an upward trajectory (P < 0.001), while students represented 4.33% of the cases. Geographically, most patients were registered in Guiyang and Zunyi, with a declining trend (P < 0.001), yet household addresses primarily clustered in Bijie, Tongren, and Zunyi. The proportion of floating population patients gradually decreased, alongside an increase in newly treated patients and those without prior anti-tuberculosis therapy. Additionally, there was a notable rise in molecular biological diagnostic drug sensitivity (real-time PCR and melting curve analysis) (P < 0.001). However, the cure rate declined, coupled with an increasing proportion of RR-PTB patients lost to follow-up and untreated (P < 0.05). Conclusions: Enhanced surveillance is crucial for detecting tuberculosis patients aged 23–28 and 44–54 years. The distribution of cases varies among nationalities and occupations, potentially influenced by cultural and environmental factors. Regional patterns in RR-PTB incidence suggest tailored prevention and control strategies are necessary. Despite molecular tests advances, challenges persist with low cure rates and high loss to follow-up. Strengthening long-term management, resource allocation, and social support systems for RR-PTB patients is essential. [ABSTRACT FROM AUTHOR]

Drought, being one of the most devastating natural disasters, has a far- reaching impact. In the context of global warming, it becomes crucial to quantitatively and scientifically assess the effects of anthropogenic climate change on meteorological drought in China. This assessment not only enhances our understanding of anthropogenic climate change but also aids in formulating more effective strategies for managing the risks associated with meteorological drought. This study employs the standardized precipitation evapotranspiration index (SPEI) to compute drought events by utilizing both observational data and counterfactual climate data (i.e., detrended observations). Subsequently, it analyzes the impact of anthropogenic climate change on the characteristics of drought, including frequency, intensity, duration, and affected area, in China as well as nine major river basins from 1960 to 2019. The outcomes of the analysis reveal that based on observational data, there is a discernible upward trend in the frequency, intensity, duration, and affected area of meteorological droughts in China. Notably, the regions experiencing an increase in frequency, intensity, and duration are primarily situated in the northeastern part of the Northwestern Rivers basin, the central and western parts of the Yellow River basin, the central and northern parts of the Yangtze River basin, the western part of the Southeastern River basins, and the eastern part of the Pearl River basin. Conversely, when considering a counterfactual climate scenario, the frequency and intensity of meteorological droughts in China demonstrate an upward trend, while the duration and affected area exhibit a downward trend. The impact of anthropogenic climate change on China has been evident in the increased frequency, intensity, duration, and affected area of droughts. Specifically, regions located in the northeastern parts of Northwest River basins, the southern part of the Songliao River basin, the northern part of the Haihe River basin, the central- northern part of the Yangtze River basin, the eastern part of the Pearl River basin, and the western part of the Southwest River basins have experienced amplified levels of drought. Anthropogenic climate change is highlighted as the primary factor influencing the observed drought characteristics changes in China, with contribution rates of 84.67%, 75.25%, 190.32%, and 133.99% for changes in the increased drought frequency, intensity, duration, and affected area, respectively. These changes have significant implications for water resource management and agricultural practices in the affected regions. [ABSTRACT FROM AUTHOR]

The rotting wood in freshwater is a unique eco-environment favoring various fungi. During our investigation of freshwater fungi on decaying wood, three hyphomycetes were collected from Jiangxi and Guangxi Provinces, China. Based on the morphological observations and phylogenetic analysis of a combined DNA data containing ITS, LSU, SSU and tef1-α sequences, two new Trichobotrys species, T. meilingensis and T. yunjushanensis, as well as a new record of T. effusa, were introduced. Additionally, a comprehensive description of the genus with both morphological and molecular data was first provided. [ABSTRACT FROM AUTHOR]

The implementation of the Environmental Protection Tax Law was a significant milestone in China's environmental tax reform. The implementation of this law was influenced throughout the three-year period of epidemic prevention and control (from early 2020 to the end of 2022). Heavily polluting enterprises are the primary focus of regulations under the Environmental Protection Tax Law. This study conducts an empirical analysis using a structural equation model, leveraging sample data obtained from heavily polluting enterprises in China. The findings indicate that during the three-year period of epidemic prevention and control, the Porter Hypothesis effect was realized in terms of tax fairness but not in terms of tax rationality. Therefore, environmental tax law reforms should be pursued and tax authorities in China should make vigorous efforts to enhance the rationality of environmental taxation. This would improve the comprehensiveness of the "Porter Hypothesis" effect, fully harnessing the dual functions of environmental protection and the economic driving force embodied by the Environmental Protection Tax Law. [ABSTRACT FROM AUTHOR]

Background: Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge to global healthcare systems. In China, the primary risk factor for HCC is the hepatitis B virus (HBV). Aberrant serum glycoconjugate levels have long been linked to the progression of HBV-associated HCC (HBV-HCC). Nevertheless, few study systematically explored the dysregulation of glycoconjugates in the progression of HBV-associated HCC and their potency as the diagnostic and prognostic biomarker. Methods: An integrated strategy that combined transcriptomics, glycomics, and glycoproteomics was employed to comprehensively investigate the dynamic alterations in glyco-genes, N-glycans, and glycoproteins in the progression of HBV- HCC. Results: Bioinformatic analysis of Gene Expression Omnibus (GEO) datasets uncovered dysregulation of fucosyltransferases (FUTs) in liver tissues from HCC patients compared to adjacent tissues. Glycomic analysis indicated an elevated level of fucosylated N-glycans, especially a progressive increase in fucosylation levels on IgA1 and IgG2 determined by glycoproteomic analysis. Conclusions: The findings indicate that the abnormal fucosylation plays a pivotal role in the progression of HBV-HCC. Systematic and integrative multi-omic analysis is anticipated to facilitate the discovery of aberrant glycoconjugates in tumor progression. [ABSTRACT FROM AUTHOR]

Objectives: We conducted this multicenter, retrospective cohort study aiming to evaluate the effectiveness and safety of vedolizumab (VDZ) and infliximab (IFX) in biologic‐naïve patients with moderate‐to‐severe ulcerative colitis (UC). Methods: Biologic‐naïve patients with moderate‐to‐severe UC who were treated with IFX or VDZ for at least 14 weeks at three tertiary hospitals in southwest China between January 2021 and January 2023 were retrospectively included. Efficacy of the biologics was evaluated based on the steroid‐free clinical remission rate, clinical remission rate, and mucosal healing rate at Weeks 14 and 52. Adverse events related to biologic use were recorded. Results: Altogether 122 biologic‐naïve patients with moderate‐to‐severe UC were included. No marked differences in the steroid‐free clinical remission rate and clinical remission rate were observed between the two groups at Week 14 or Week 52 (P > 0.05). The VDZ group exhibited a higher mucosal healing rate at Week 14 compared to the IFX group (33.3% vs 16.9%, P = 0.036), while that at Week 52 did not differ between the two groups (65.6% vs 47.1%, P = 0.098). There was no statistically significant difference in the rate of adverse events between the two groups (P = 0.071). Conclusion: VDZ and IFX showed comparable clinical efficacy and safety profiles and can be used as viable first‐line therapeutic options for biologic‐naïve patients with moderate‐to‐severe UC. [ABSTRACT FROM AUTHOR]

Desertification is showing a trend of overall reversal and partial expansion in the agro-pastoral ecotone in northern China (APENC). Dune–interdune is the typical micro-topography in APENC and is the expansion area of desertification. Research on anti-desertification strategy at dune–interdune is of great significance to further anti-desertification. This paper studies the vertical differentiation of land use and ecosystem service intensities at dune–interdune in APENC. The fundamental reason of the vertical differentiation of land use and ecosystem service intensities is explored with monitoring data of soil moisture at different locations of dune–interdune. Cultivated land is mainly distributed in areas with an elevation < 241 m. Grain provisioning ecosystem service intensity (GPESI) and maize leaf provisioning ecosystem service intensity (MLPESI) show a downward trend with the increase in elevation at dune–interdune. GPESI has a tipping point at the elevation of 241 m. Forage provisioning ecosystem service intensity and sand fixation regulating ecosystem service intensity are high in areas with low or high elevations while low in the central area. Groundwater depth is the root cause for vertical differentiation of land use and ecosystem service intensities at dune–interdune. According to vertical changes of land use and ecosystem service intensities, and groundwater level, cultivated land with an elevation greater than 241 m should be stopped for cultivation to anti-desertification. The area of dune–interdune within 6 m of groundwater depth can be used as cultivated land. The conclusion has an important reference for other similar regions in the world. [ABSTRACT FROM AUTHOR]

In China, state-owned firms exhibit easier access to external credit but have lower productivity than private firms. We construct a dynamic general equilibrium model incorporating heterogeneous financial frictions to investigate their impact on credit resource misallocation and macroeconomic fluctuations in the Chinese economy. A calibration of our model suggests that heterogeneity in financial frictions can reduce macroeconomic volatility. The mechanism is that heterogeneity in financial frictions induces the procyclicality of credit resource misallocation within entrepreneurs, thus the procyclicality of productivity loss. The stabilization effect depends on the relative magnitude of the impact of the shock on credit resource misallocation within entrepreneurs compared to its impact on the output. In addition, we show that the cost of the stabilization effect of heterogeneity in financial frictions is that it reduces the economy's aggregate TFP and output at the steady state. Our results imply that neglecting heterogeneity may overestimate the impact of financial frictions on economic volatility in previous studies. [ABSTRACT FROM AUTHOR]

Listed companies in China have provided large numbers of loan guarantees for borrowers in recent years. The loan guarantee size of A-share Main Board listed companies was about RMB 3.85 trillion at the end of 2017. On the one hand, loan guarantees help borrowers access debt financing, which promotes the development of capital markets. On the other hand, however, loan guarantees can increase the financial risks for guarantors. This study investigates the effects of loan guarantees on guarantors' accounting conservatism. Based on a large sample of listed companies from 2007 to 2017, we find that loan guarantees have a significant positive effects on guarantors' accounting conservatism. When firms provide loan guarantees for borrowers, they report more conservative accounting information. Moreover, the effect of loan guarantees on accounting conservatism varies by borrower. Listed companies report more conservative accounting information when they provide guarantees for non-subsidiaries rather than for subsidiaries. Among the companies providing guarantees for non-subsidiaries, the companies engage in higher levels of accounting conservatism when they guarantee the borrowing of controlling shareholders instead of the borrowing of non-controlling shareholders. [ABSTRACT FROM AUTHOR]

The uneven changes in potential evapotranspiration (PET) in response to temperature rise are called the 'evapotranspiration paradox' phenomenon, which is expected to intensify further under a warming climate. In this paper, we explored the spatial–temporal changes in the future 'evapotranspiration paradox' phenomenon over China and its 10 major river sub‐regions under different climate change scenarios. Thus, this paper uses four global climate model outputs under seven shared socioeconomic pathway‐based scenarios (SSP1‐1.9, SSP1‐2.6, SSP2‐4.5, SSP3‐7.0, SSP4‐3.4, SSP4‐6.0 and SSP5‐8.5) from the sixth phase of the Coupled Model Intercomparison Project (CMIP6). Considering the latest IPCC's 6th Assessment Report (AR6), this research emphasizes the 2021–2040 (near‐term), 2041–2060 (mid‐term) and 2081–2100 (long‐term) periods to anticipate the 'evapotranspiration paradox' phenomenon. In this study, PET is estimated based on the modified Penman–Monteith (P‐M) method (considering CO2). Furthermore, the paradox phenomenon in this study is defined considering two pivotal conditions: the surface temperature increases but the evaporation decreases (Type I), and the temperature decreases but the evaporation still tends to increase (Type II). The results show that there were only Type I 'evapotranspiration paradoxes' that existed in the historical period, which were dominant especially before the 1990s. Nearly 50% of the areas experienced the Type I 'evapotranspiration paradox' phenomenon that occurred during 1975–1994 and 1995–2014. Spatially, it covered 100% of the area of the Southeast River (SER) and the Liaohe River (LR) during 1975–1994 and the area of the SER, the HAR, the HHR and the LR during 1995–2014. In the future, the interdecadal growth rate of PET in China is projected to be the highest under the SSP5‐8.5 and the lowest under the SSP3‐7.0 with spatial variation. Importantly, the largest areas of approximately 36% and 45% with the Type I phenomenon are inclined to occur under the SSP1‐1.9 and SSP4‐6.0, respectively, over the long‐term period (2081–2100). The area with the Type I phenomenon will be less than 20% in the near‐term, and it is less than 12% in the mid‐term period. For the Type II evapotranspiration paradox, the uppermost 45% of the area is expected to experience the Type II phenomenon under SSP1‐1.9 during the mid‐term period, while it is 30% under SSP1‐2.6 during the long‐term period. However, this study's findings provide the scientific basis for formulating adaptation and mitigation strategies to combat 'evapotranspiration paradox'‐related extremes at regional scales. [ABSTRACT FROM AUTHOR]

Simple Summary: The complete mitochondrial genome has been widely used in phylogenetics-related studies, as it offers valuable insights into evolutionary relationships. In this study, we reported the complete mitogenome of the elongate loach (Leptobotia elongata) and conducted a detailed analysis of its characteristics which was employed to infer phylogenetic relationships. These findings reveal that both the gene arrangement and composition of mitochondrial genes in the elongate loach are comparable to those found in other bony fishes. Our study further demonstrated that the Cobitidae species under investigation could be grouped into two distinct clades, with elongate loach showing a sister relationship with L. microphthalma. Collectively, our research enhanced the understanding of the mitochondrial genome structure and contributed to the phylogenetic analysis of the elongate loach. The elongate loach is an endemic fish in China. Previous studies have provided some insights into the mitochondrial genome composition and the phylogenetic relationships of the elongate loach inferred using protein-coding genes (PCGs), yet detailed information about it remains limited. Therefore, in this study we sequenced the complete mitochondrial genome of the elongate loach and analyzed its structural characteristics. The PCGs and mitochondrial genome were used for selective stress analysis and genomic comparative analysis. The complete mitochondrial genome of the elongate loach, together with those of 35 Cyprinidae species, was used to infer the phylogenetic relationships of the Cobitidae family through maximum likelihood (ML) reconstruction. The results showed that the genome sequence has a full length of 16,591 bp, which includes 13 PCGs, 22 transfer RNA genes (tRNA), 2 ribosomal RNA genes (rRNA), and 2 non-coding regions (CR D-loop and light chain sub-chain replication origin OL). Overall, the elongate loach shared the same gene arrangement and composition of the mitochondrial genes with other teleost fishes. The Ka/Ks ratios of all mitochondrial PCGs were less than 1, indicating that all of the PCGs were evolving under purifying selection. Genome comparison analyses showed a significant sequence homology of species of Leptobotia. A significant identity between L. elongata and the other five Leptobotia species was observed in the visualization result, except for L. mantschurica, which lacked the tRNA-Arg gene and had a shorter tRNA-Asp gene. The phylogenetic tree revealed that the Cobitidae species examined here can be grouped into two clades, with the elongate loach forming a sister relationship with L. microphthalma. This study could provide additional inferences for a better understanding of the phylogenetic relationships among Cobitidae species. [ABSTRACT FROM AUTHOR]

Rockburst is a frequent challenge during tunnel and other underground construction and is an extreme rock damage phenomenon. Therefore, it is very crucial to accurately estimate the damage potential of rockburst events. Microseismic (MS) monitoring can be used to obtain the relevant MS parameters for short-term rockburst prediction in real time that reflect the evolution of short-term rockburst. In this study, short-term rockburst potential data containing 7 MS parameters (cumulative number of events, cumulative released energy, cumulative apparent volume, event rate, energy rate, apparent volume rate, and incubation time) and 91 rockburst events (none rockburst, low rockburst, moderate rockburst, and high rockburst) were collected from the Jinping Hydropower Station diversion tunnel project in China. The objective of this paper is to propose an ensemble learning (EML) model based on the LévyFlight-Jaya optimization (LFJaya) and fivefold cross-validation (CV) method to achieve an accurate prediction of short-term rockburst damage potential using MS information. The EML consists of light gradient boosting machine (LGBM), extreme gradient boosting (XGBoost), random forest (RF), support vector machine (SVM), and logistic regression (LR), with seven MS parameters as the EML inputs and four rockburst levels as target variables. 70% and 30% of the cases were randomly selected for training and testing, respectively. Five metrics (accuracy, kappa, precision, recall, and F1-score) and nonparametric statistical tests were used to evaluate the performance of the model. It can be observed from the results of this study that the proposed EML has a higher test accuracy (89.29%) than the multiple base classifiers used in the study. With the use of the ensemble model, the decision boundary becomes more precise and overfitting is significantly improved. Additionally, the internal decision-making process of EML was elucidated through an analysis of the model parameters using SHapley Additive exPlanations (SHAP) and Local Interpretable Model-agnostic Explanations (LIME). It was discovered that the cumulative released energy, the number of MS events, and the cumulative apparent volume (which reflects the number and strength of rock fractures) exert a significant influence on the prediction of short-term rockburst potential. Finally, developed graphical user interface (GUI) accurately predicted six instances of rockburst in the deeply buried tunnel of Jinping. Verification results indicated that the proposed EML exhibits strong generalization and can effectively utilize MS information to achieve precise short-term rockburst potential predictions. [ABSTRACT FROM AUTHOR]

Blasting constitutes an essential component of the mining and construction industries. However, the associated nuisances, particularly blast vibration, have emerged as significant concerns that pose threats to operational stability and the safety of the surrounding areas. Given the increasing emphasis on sustainability, ecological responsibility, safety, and geo-environmental practices, the impact of blast vibration has garnered heightened attention and scrutiny. Nevertheless, the field still lacks comprehensive phase analysis studies. Therefore, it is imperative to elucidate the research progress on blast vibration and discern its current frontiers of investigation. To address this need, this study employs bibliometric methods and the CiteSpace 6.1.R2 software to analyze 3093 papers from the Web of Science database. Through this comprehensive analysis, the study aims to chronicle the developmental trajectory, assess the present research status, and identify future trends in the field of blast vibration. The findings of this study reveal that research on "blasting vibration" is advancing rapidly, with the number of citations exhibiting a J-shaped growth curve over time. China emerges as the leading contributor to this research, followed by India, and the foremost institution in this field is Central South University in China. Cluster analysis identifies the effects of ground vibration, numerical simulation, blast load, blasting vibration and rockburst hazard as the most prominent research areas presently. The primary research directions in this domain revolve around the rock fragmentation, compressive strength, particle swarm optimization, and ann. The emergence of these keywords underscores a dynamic shift towards a more holistic and multidisciplinary approach in the field of blasting-induced ground vibration. Furthermore, this study provides a concise overview of blast vibration, discusses prediction techniques, and proposes measures for its control. Additionally, the discussion delves into the social significance of intelligent blasting systems within the context of artificial intelligence, aiming to address the hazards associated with blast-induced ground vibrations. [ABSTRACT FROM AUTHOR]

Aims and Objectives: This study aimed to determine the relationship between the demand for telenursing and the chronic illness resources available to patients with type 2 diabetes mellitus (T2DM), as well as the factors that affect this requirement. Design: Cross‐sectional. Methods: This study included 586 participants with T2DM. A telenursing needs questionnaire developed by the research team was used to assess the telenursing needs of patients with T2DM, and the Chinese version of the Chronic Illness Resources Survey was used to assess the participants' community chronic disease resources. A one‐way ANOVA and multiple regression analysis were used to determine the factors influencing the demand for telenursing and to estimate the relationship between chronic illness resources and the need for telenursing. The STROBE checklist was followed. Results: The patients' telenursing needs, ranked from high to low, are as follows: individualized skills and safety; basic disease care; psychological and spiritual needs; respect and social support; and high‐level health management. The chronic disease resource score was 3.47 ±.02, which suggested that patients with T2DM have relatively rich disease resources. Multiple regression analyses showed that resources for chronic diseases, the course of diabetes and complications, family income and other chronic diseases accounted for 79.6% of the variance in T2DM patients' telenursing needs. Conclusions: The telenursing needs of patients with T2DM are prominent, and primarily focus on basic nursing needs for the disease. To some extent, chronic disease resources affect the telenursing needs of patients with T2DM. Relevance to Clinical Practice: It is crucial to pay attention to research on telenursing for T2DM patients from the patients' perspective. Enhancing resources for chronic diseases may help meet the telenursing needs of T2DM patients. Patient or Public Contribution: Parents and diabetes management specialists participated in designing the telenursing needs questionnaire. [ABSTRACT FROM AUTHOR]

Adequate blood supply, a prerequisite for flap survival after grafting, makes angiogenesis of the flap the biggest problem to be solved. Researches have been conducted around vascularisation in correlation with flap grafting. However, bibliometric analyses systematically examining this research field are lacking. As such, we herein sought to conduct comprehensive comparative analyses of the contributions of different researchers, institutions, and countries to this research space in an effort to identify trends and hotspots in angiogenesis and vascularisation in the context of flap grafting. Publications pertaining to angiogenesis and vascularisation in the context of flap grafting were retrieved from the Web of Science Core Collection. References were then analysed and plotted using Microsoft Excel 2019, VOSviewer, and CiteSpace V. In total, 2234 papers that were cited 40 048 times (17.63 citations/paper) were included in this analysis. The greatest number of studies were from the United States, with these studies exhibiting both the highest number of citations (13 577) and the greatest overall H‐index (60). For The institutions that published the greatest number of studies were WENZHOU MEDICAL UNIVERSITY (681), while UNIVERSITY OF ERLANGEN NUREMBERG has the highest number of citations (1458), and SHANGHAI JIAO TONG UNIVERSITY holds the greatest overall H‐index (20). The greatest number of studies in this research space were published by Gao WY, while Horch RE was the most commonly cited researcher in the field. The VOS viewer software clustered relevant keywords into three clusters, with clusters 1, 2, 3, and 4 corresponding to studies in which the keywords 'anatomy', 'survival', 'transplantation', 'therapy' most frequently appeared. The most promising research hotspot‐related terms in this field included 'autophagy', 'oxidative stress', 'ischemia/reperfusion injury', which exhibited a most recent average appearing year (AAY) of 2017 and after. Generally speaking, the results of this analysis indicate that the number of articles exploring angiogenesis and flap‐related research has risen steadily, with the United States and China being the two countries publishing the greatest proportion of studies in this field. The overall focus of these studies has shifted away from 'infratest and tissue engineering' towards 'mechanisms'. In the future, particular attention should be paid to emerging research hotspots, which include 'ischemia/reperfusion injury' and treatments for promoting vascularization, such as 'platelet‐rich plasma'. In light of these findings, funding agencies should continue increasing their investment in the exploration of the concrete mechanisms and interventional therapeutic relevance of angiogenesis during flap transplantation. [ABSTRACT FROM AUTHOR]

Background: Primary liver cancer, of which around 75–85% is hepatocellular carcinoma in China, is the fourth most common malignancy and the second leading cause of tumor-related death, thereby posing a significant threat to the life and health of the Chinese people. Summary: Since the publication of Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China in June 2017, which were updated by the National Health Commission in December 2019, additional high-quality evidence has emerged from researchers worldwide regarding the diagnosis, staging, and treatment of liver cancer, that requires the guidelines to be updated again. The new edition (2022 Edition) was written by more than 100 experts in the field of liver cancer in China, which not only reflects the real-world situation in China but also may reshape the nationwide diagnosis and treatment of liver cancer. Key Messages: The new guideline aims to encourage the implementation of evidence-based practice and improve the national average 5-year survival rate for patients with liver cancer, as proposed in the "Health China 2030 Blueprint." [ABSTRACT FROM AUTHOR]

The number of studies considering building performance optimization (BPO) in the building design phase is steadily growing, but many of the existing studies do not consider the applicability of many-objective optimization algorithms when increasing the objective dimensions. This article first compares the NSGA-II, IDBEA, MSOPS-II, and NSGA-III algorithms. Then, the algorithm most suitable for many-objective optimization is combined with Artificial natural network(ANN) and TOPSIS-AHP to complete the optimization of four dimensions of building energy consumption (EC), useful daylight illuminance (UDI), comfort time ratio (CTR) and energy-saving envelope cost (ESEC) for village houses in cold regions of China. The results show that the NSGA-III algorithm performs well in terms of convergence speed, convergence, diversity, and uniformity when solving many-objective problems compared to the other three algorithms. Finally, four optimization strategies were selected using the TOPSIS-AHP method. [ABSTRACT FROM AUTHOR]

Nowadays, the contemporary ecological environment has a significant impact on human survival and development. Consequently, an in-depth examination of the link between humans and nature has significant practical significance and aspirational appeal. This research analyzes provincial panel data from 2011 to 2019 using an empirical model to determine the relationship between urban land use, the ecological environment, and national physical health inputs in China. The results indicate that (1) urbanization and air pollution do not have an "inverted U-shaped" traditional environmental Kuznets curve relationship, but rather a significant "positive U" relationship; (2) urbanization and environmental management do have an inverted U-shaped classical environmental Kuznets curve relationship; (3) GDP per capita and infrastructure have a negative impact on air quality and environmental quality, and strict environmental rules can improve air quality and green amenities; (4) national physical health investment has a substantial moderating effect on the relationship between urban land use and the ecological environment. [ABSTRACT FROM AUTHOR]

Background: Oriental river prawn (Macrobrachium nipponense) is one of the most dominant species in shrimp farming in China, which is a rich source of protein and contributes to a significant impact on the quality of human life. Thus, more complete and accurate annotation of gene models are important for the breeding research of oriental river prawn. Results: A full-length transcriptome of oriental river prawn muscle was obtained using the PacBio Sequel platform. Then, 37.99 Gb of subreads were sequenced, including 584,498 circular consensus sequences, among which 512,216 were full length non-chimeric sequences. After Illumina-based correction of long PacBio reads, 6,599 error-corrected isoforms were identified. Transcriptome structural analysis revealed 2,263 and 2,555 alternative splicing (AS) events and alternative polyadenylation (APA) sites, respectively. In total, 620 novel genes (NGs), 197 putative transcription factors (TFs), and 291 novel long non-coding RNAs (lncRNAs) were identified. Conclusions: In summary, this study offers novel insights into the transcriptome complexity and diversity of this prawn species, and provides valuable information for understanding the genomic structure and improving the draft genome annotation of oriental river prawn. [ABSTRACT FROM AUTHOR]

China has implemented a series of long-term measures to control the spread of COVID-19, however, the effects of these measures on other chronic and acute respiratory infectious diseases remain unclear. Tuberculosis (TB) and scarlet fever (SF) serve as representatives of chronic and acute respiratory infectious diseases, respectively. In China's Guizhou province, an area with a high prevalence of TB and SF, approximately 40,000 TB cases and hundreds of SF cases are reported annually. To assess the impact of COVID-19 prevention and control on TB and SF in Guizhou, the exponential smoothing method was employed to establish a prediction model for analyzing the influence of COVID-19 prevention and control on the number of TB and SF cases. Additionally, spatial aggregation analysis was utilized to describe spatial changes in TB and SF before and after the COVID-19 outbreak. The parameters of the TB and SF prediction models are R2 = 0.856, BIC = 10.972 and R2 = 0.714, BIC = 5.325, respectively. TB and SF cases declined rapidly at the onset of COVID-19 prevention and control measures, with the number of SF cases decreasing for about 3–6 months and the number of TB cases remaining in decline for 7 months after the 11th month. The spatial aggregation of TB and SF did not change significantly before and after the COVID-19 outbreak but exhibited a marked decrease. These findings suggest that China's COVID-19 prevention and control measures also reduced the prevalence of TB and SF in Guizhou. These measures may have a long-term positive impact on TB, but a short-term effect on SF. Areas with high TB prevalence may continue to experience a decline due to the implementation of COVID-19 preventive measures in the future. [ABSTRACT FROM AUTHOR]

Introduction: The actual rate of conversion surgery and its prognostic advantages remain unclear. This study aimed to assess the outcomes of salvage surgery after conversion therapy with triple therapy (transcatheter arterial chemoembolization [TACE] combined with lenvatinib plus anti-PD-1 antibodies) in patients with initially unresectable hepatocellular carcinoma (uHCC). Methods: Patients with initially uHCC who received at least one cycle of first-line triple therapy and salvage surgery at five major cancer centers in China were included. The primary endpoints were overall survival (OS) and recurrence-free survival (RFS) rates after salvage surgery. The secondary endpoints were perioperative complications, 90-day mortality, and pathological tumor response. Results: Between June 2018 and December 2021, 70 patients diagnosed with uHCC who underwent triple therapy and salvage surgery were analyzed: 39 with Barcelona Clinic Liver Cancer (BCLC) stage C, 22 with BCLC stage B, and 9 with BCLC stage A disease. The median interval between the start of triple therapy and salvage surgery was 4.3 months (range, 1.7–14.2 months). Pathological complete response and major pathological response were observed in 29 (41.4%) and 59 (84.3%) patients, respectively. There were 2 cases of perioperative mortality (4.3%) and 5 cases of severe perioperative complications (7.1%). With a median follow-up of 12.9 months after surgery (range, 0.3–36.8 months), the median OS and RFS were not reached. The 1- and 2-year OS rates were 97.1% and 94.4%, respectively, and the corresponding RFS rates were 68.9% and 54.4%, respectively. Conclusion: First-line combination of TACE, lenvatinib, and anti-PD-1 antibodies provides a better chance of conversion therapy in patients with initially uHCC. Furthermore, salvage surgery after conversion therapy is effective and safe and has the potential to provide excellent long-term survival benefits. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the impact on surgical efficiency and labor time cost of preloaded intraocular lens (IOL) implantation system compared with manual IOL implantation system in age-related cataract surgery in China. Methods: This study was an observational, multicenter, prospective time-motion analysis. IOL preparation time, operation time, cleaning time, number and cost of cataract surgeries in eight participating hospitals were collected. The linear mixed model was used to explore factors associated with the difference in operation time between the preloaded IOL implantation system and the manual IOL implantation system. A time-motion model was constructed to convert the operation time cost saved by using preloaded IOL into economic benefits from hospital and social perspective, respectively. Results: There were 2,591 cases included in the study (preloaded IOL: 1,591 cases; manual IOL: 1,000 cases). The preloaded IOL implantation system was significant time-saving in both preparation time and operation time compared to the manual IOL implantation system (25.48s vs. 47.04s, P < 0.001 and 353.84s vs. 367.46s, P = 0.004, respectively). An average total of 35.18s can be saved by using preloaded IOL per procedure. The results of linear mixed model showed that the type of IOL was the main factor leading to the difference in preparation time between preloaded IOL and manual IOL implantation system. By switching from manual IOL to preloaded IOL, the model projected additional 392 surgeries can be performed each year and an increase in revenue of $565,282 per hospital, a 9% increase from hospital perspective. And the annual productivity loss saved by using preloaded IOL was $3,006 in eight hospitals from perspective of society. Conclusion: Compared with manual IOL implantation system, the preloaded IOL implantation system reduces lens preparation time and operation time, which increases potential surgical volume and revenue, and reduces the loss of work productivity. This study provides real-world evidence to support the advantages of the preloaded IOL implantation system in improving efficiency of ophthalmic surgery in China. [ABSTRACT FROM AUTHOR]

The morphological changes based on deposition of secondary dentin and mineralization of the third molar have been proven to be related to chronological age. However, Kvaal's method on the theory of deposition of secondary dentin was controversial with respect to dental age estimation in the recent research. The aim of this study was to combine the parameters of Kvaal's method with relatively high correlation coefficients and mineralization stages of the third molar to improve the accuracy of predicting the dental age of subadults in northern China. A total of 340 digital orthopantomograms of subadults aged from 15 to 21 years were analysed. A training group was used to test the accuracy of the original Kvaal's method and to establish novel methods for subadults in northern China. A testing group was used to compare the accuracy of the newly established methods with the Kvaal's original method and with published method specifically used in northern China. To increase the feasibility of our estimation model, we combined the mineralization of the third molar to build a combined specific formula. The results showed that the combined specific model increased the coefficient of determination to 0.513, and the standard error of the estimate was reduced to 1.482 years. We concluded that the combined specific model based on the deposition of secondary dentin and mineralization of the third molar could improve the accuracy of dental age assessment of subadults in northern China. Key Points The decrease in the dental pulp cavity based on deposition of secondary dentin is a useful variable for assessing age. A total of 340 orthopantomographs were used in this research, including 278 in training groups and 62 in testing groups. Original Kvaal's method underestimated the dental age for subadults in northern China. The equation of combined specific method constructed in our study was proved more suitable to calculate dental age for subadults in northern China. [ABSTRACT FROM AUTHOR]

Transparent exopolymer particles (TEP) are essential for the carbon cycle in aquatic environments. However, the distribution of TEP, its precursor, and the contribution to the organic carbon pool in the large freshwater lake remain inadequately understood. Here, we focused on the spatial distribution of TEP and dissolved acidic polysaccharides (dAPS) in four typical seasons in Lake Taihu, the third-largest lake in China. TEP concentrations in Lake Taihu ranged from 0.05 to 5.19 mg Xeq/L, with a mean value of 1.31 ± 1.08 mg Xeq/L. The concentration of dAPS in the lake averaged 3.7 ± 2.19 mg Xeq/L (range, 0.19–13.12 mg Xeq/L). Higher content of TEP and dAPS was found in summer, and their distributions appeared to be influenced by the cyanobacterial blooms, as they showed significant correlations with chlorophyll-a content in Lake Taihu in summer. In addition, TEP accounted for an average of 24.3% of particulate organic carbon, and dAPS represented 25.9% of dissolved organic carbon. These results provide valuable insights into the contribution of TEP to organic carbon pools in inland waters and highlight the role of TEP in the carbon cycling of large freshwater lakes. [ABSTRACT FROM AUTHOR]

The phenotypic characteristics of forest seeds are the basis of germplasm innovation, genetic improvement, and biological research, and they also are the reference for the development of seed orchards. In this study, we analyzed seed quantity characteristics, phenotypic differentiation, and variation patterns in three seed-bearing clones from different crown layers of the Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) orchard located in Fujian Province, China. We divided the clones into six layers according to crown height and the sunny and shady sides, 14 phenotypic characteristics, and five quality indexes, and we measured the germination rate of seeds. The rate of seeds filled with tannin-like substance in the upper sunny layer was low, but it was high in the lower shady layer. The germination rate was highest in the upper sunny layer and lower in the middle and lower shady sides. Values of most of the 14 phenotypic traits tested differed significantly among clones and layers. The average value of the phenotypic differentiation coefficient was 81.16%, indicating that variation among clones explained most of the total phenotypic variation. The repeatability of the 14 phenotypic traits was high (R > 0.80), indicating that these traits are highly heritable. The phenotypic characteristics of cones and seeds varied from 6.86% to 129.51%. The 14 phenotypic traits exhibited different degrees of correlation, and seed weight, seed circumference, seed width, and seed area can be used to predict other seed traits. However, the correlations between cone traits were not strong. Our results show that when establishing a dwarfing Chinese fir seed orchard, the distribution and variation of seeds in different crown layers of clones should be considered, and clones with more cones in the lower crown layer should be selected as parents. [ABSTRACT FROM AUTHOR]

Land consolidation (LC) in China is an important means by which we can increase the quantity and improve the quality of cultivated land. At present, large areas of cultivated land are abandoned in mountainous areas. It is unclear whether the increased cultivated land from LC in mountainous areas is sustainably used. Data from 64 land consolidation zones completed in 2016 in the Qinba Mountain Area were collected. The land-use status was obtained from high-resolution remote sensing images by the method of visual interpretation, and land-use changes were analyzed. According to our results, the increased cultivated land by LC is mainly terrace, accounting for 92.22% of the total area of increased cultivated land. The increased cultivated land is mainly distributed in the Qinba Mountainous Area, and terrace is the main type of increased cultivated land in both the Hanzhong Basin Area and Qinba Mountainous Area. The transformation rate of cultivated land from LC, especially terrace, is small. The transformation rates of terrace in the Hanzhong Basin Area and Qinba Mountainous Area are 0.36% and 0.09%, respectively. The socioeconomic development in mountainous areas is relatively lagging, and the per capita cultivated land area is small. Many farmers are still engaged in agricultural production and earn a basic income. Thus, high-quality cultivated land with convenient transportation is sustainably used. LC remains a key avenue for increasing cultivated land area, improving agricultural productivity, increasing farmers' incomes, and promoting rural development in the mountainous areas. [ABSTRACT FROM AUTHOR]

Background. Avatrombopag has been approved in patients who have severe thrombocytopenia (<50 × 109/L) and chronic liver disease (CLD) while receiving invasive procedures. The real-world application and effectiveness of avatrombopag in the subgroup patients with liver cancer remain unknown. Methods. Liver cancer patients (including primary liver cancer and colorectal cancer liver metastasis) who had severe thrombocytopenia and received avatrombopag were retrospectively enrolled. Avatrombopag dose, peak and absolute platelet count increase, combination treatment with other thrombopoietic agents, responder (peak count ≥50 × 109/L with absolute increase ≥20 × 109/L) rate, and anticancer treatment effect were analyzed. Thrombosis and bleeding events were assessed. Results. In total, 93 patients were enrolled, with 72 and 21 in the CLD and non-CLD groups, respectively. Patients with CLD had hepatitis B or C, larger spleen volume, and a higher cirrhosis degree. Baseline platelet counts were similar between two groups (median, 37.0 × 109/L vs. 39.0 × 109/L; P = 0.594), while patients without CLD had higher peak platelet (median, 134.0 × 109/L vs. 74.0 × 109/L; P = 0.015) and absolute increase (median, 101.0 × 109/L vs. 41.0 × 109/L; P = 0.020) after avatrombopag treatment. The responder rate was higher in patients without CLD (100% vs. 76.4%; P = 0.010). Combined avatrombopag with other thrombopoietic agents significantly increased platelet count; repeated use of avatrombopag produced similar effects with that of initial treatment. Concerning anticancer treatment effect, patients who responded to avatrombopag had a higher disease control rate. No thrombosis or hemorrhagic events were observed, even in patients with portal vein tumor thrombosis. Conclusion. Avatrombopag was safe and effective and ensured successful implementation of anticancer treatment in liver cancer patients with severe thrombocytopenia, accompanied with or without CLD. [ABSTRACT FROM AUTHOR]

The Luobei Complex in Northeast (NE) China lies in the northern Heilongjiang Complex and comprises a sequence of low-temperature–high-pressure metamorphic rocks distributed along the N–S-oriented suture zone between the Jiamusi and Songliao blocks. However, the timing of formation and tectonic setting of the Luobei Complex remain poorly constrained. Here, we present petrological, geochronological, and geochemical data for metasedimentary rocks from the Luobei Complex to elucidate its origin and tectonic setting. The Luobei Complex is characterised by the occurrence of serpentinite, blueschist, greenschist, amphibolite, and marble, which form lenses or interlayers in a matrix of two-mica schist, albite schist, quartz schist, and granitic gneiss. Zircon U–Pb dating of four metasedimentary rocks yields consistent Late Triassic maximum depositional ages (ca. 214 Ma). Detrital zircons from the Luobei Complex yield ages ranging from 1889 to 202 Ma, with age peaks at 504, 350, 265, and 214 Ma. The ages prior to 350 Ma exist in both the Jiamusi Block and the Central Asia Orogenic Belt (CAOB), indicating that the syn-deposition of Luobei Complex, meanwhile, the lack of ages younger than 350 Ma suggests that the Jiamusi Block rifted eastward from the CAOB. Geochemical data indicate that the studied metasedimentary rocks were formed in a continental island arc setting. These results, together with the Early Jurassic metamorphism reported by previous studies, constrain the timing of final collision to Late Triassic–Early Jurassic after subduction of the Jiamusi Block beneath the Songliao Block. Combining our new results with previous findings, we propose a new tectonic model: (1) during the latest Carboniferous to Late Triassic, the Jiamusi Block rifted from the CAOB as a result of Mongol–Okhotsk oceanic plate subduction; and (2) during the Late Triassic and Early Jurassic, the Jiamusi Block was reunited with the Songliao Block, and the Heilongjiang Complex formed, as a result of Paleo-Pacific plate subduction. [ABSTRACT FROM AUTHOR]

The production of bio‐ethylene is a promising way to replace fossil‐based ethylene production, reducing greenhouse gas emissions and working towards China's carbon neutrality goals. This study elaborates on five bio‐ethylene technological pathways: first‐ and second‐generation bioethanol dehydration, direct and indirect thermochemical synthesis, and methanol‐to‐olefins (MTO). It retrieves information about them from commercial patents and the scientific literature, and comprehensively assesses their potential for application in large‐scale ethylene production in China. The techno‐economic feasibility of these five technological pathways is discussed in terms of feedstock availability, investment level, technological development level, and political issues such as the carbon neutrality goal to which China's government is committed. Overall, two pathways (indirect thermochemical synthesis and MTO) exhibited competitive minimum ethylene selling prices at 5243 yuan/t (822 USD t–1) and 6767 yuan/t (1061 USD t–1), respectively, of which both are lower than the average ethylene market price of 7000 yuan/t (1098 USD t–1). In comparison with the conventional fossil‐derived ethylene, bio‐ethylene could decrease carbon emission by 3.2%–15.1% under a scenario of 20% bio‐ethylene substitution in 2019, showing promising potential for decarbonizing the ethylene industry and contributing to the achievement of China's carbon neutrality goals. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Many healthcare professionals base their perceptions of pediatric pain on their knowledge of the subject. Therefore, knowledge deficits in this area may yield negative attitudes toward pain management and add to the complexity of pain management in hospitalized children. This study evaluated the knowledge of pediatric clinicians in China regarding pediatric pain management. Adopting a cross-sectional descriptive comparative design, we surveyed pediatric clinicians using a structured questionnaire. Inclusive criteria were pediatric clinicians, both pediatricians and nurses, with professional pediatric experience of over one year. A total of 507 pediatric clinicians participated. Most were aware of the importance of pain management in sick children but misunderstood pediatric pain, lacked knowledge for performing pediatric pain assessments and lacked knowledge for providing pain relief interventions. Background factors including differing professions (pediatricians and nurses; p = 0.012), age (p < 0.05) and hospital setting of employment (p = 0.003) were significantly related to clinicians' knowledge regarding pain management. Participating pediatricians had higher levels of knowledge of pediatric pain management than nurses. Research revealed four barriers affecting clinicians' knowledge, including misconception of pain in children, lack of professional knowledge and confidence in the practice of pediatric pain assessment, lack of professional knowledge to provide pain relief interventions, and a significant knowledge gap between pediatricians and nurses. The results point out a crucial need for multidisciplinary education to remedy these deficiencies. Further study is needed to explore strategies to strengthen clinicians' knowledge of this vital area of practice. [ABSTRACT FROM AUTHOR]

China has been implementing a brand-new reform in agricultural education and teaching, and the construction of a first-class curriculum is an important guarantee for improving teaching quality and talent training. In line with the survey results of senior students from the field of landscape architecture, 15 frequent elements are selected, namely, teaching team, teaching strategy, teaching method, curriculum ideology and politics, online teaching, offline teaching informatization, teaching material resources, hardware resources, social resources, curriculum structure, teaching process, curriculum organization, applicability, foresight, innovation, and practicality. According to affiliation relationships, they are then classified into five clusters, which are curriculum intelligence support, informatization, resources, normalization, and content. By adopting the analytic network process method and using the super decision software, the hierarchical network model reflecting the dependence and feedback relationship between elements is established. The research results show that, among the five clusters, curriculum content and intelligence support weight relatively are high, which account for 67% of the total weight. The elements of the teaching team, online teaching, teaching material resources, teaching process normalization, and applicability and practicality of curriculum content weigh high, respectively, among the clusters. In the overall ranking of the system weight, the weights of three elements exceed 0.1, namely, the teaching team, content practicability, and teaching process normalization. The weights of the top eight elements account for approximately 85% of the total weight. This study can be used as a reference for the optimal allocation of curriculum construction resources. [ABSTRACT FROM AUTHOR]

Systematically identification and building of digital capability in the Digital Age are of great significance to the obtainment of enterprises’ sustainable competitive advantages. This article first proposes typical application paradigms for the general framework of building digital capability of industrial enterprises in the Digital Age (FBDC) announced as international standard. Then data of over 4100 practical cases of building digital capabilities using FBDC by over 4000 Chinese industrial enterprises are collected. Based on the data, major directions, core implementations of digital capabilities building are systematically demonstrated through statistical analysis. Furthermore, we divide the investigated enterprises into different groups by sector, then organize in-depth research works to illustrate the major directions and typical practices of building digital capabilities in China's raw materials sector, equipment sector, and consumer goods sector. The results show that the major concerns of Chinese industrial enterprises building digital capabilities are centered on six aspects: R&D and innovation, production management and control, supply chain management, financial management and control, business management, and customer service. The results of sector-wise analysis also provide practical reference to industrial enterprises and other stakeholders to identify suitable digital capability based on information and communication technologies application in the Digital Age and efficiently implement the digital capability building process. [ABSTRACT FROM AUTHOR]

The Jiamusi‐Khanka Massif is an important tectonic unit of the Central Asian Orogenic Belt in North‐east China. Its Late Palaeozoic tectonic properties and the timing of assembly have restricted the understanding of the tectonic evolution process at the eastern segment of the Central Asian Orogenic Belt for a long time. Based on the study of clastic rock petrology and zircon U–Pb chronology of the Early Permian Erlongshan Formation in Mishan, it is clear that the zircon age of the Early Permian Erlongshan Formation in Mishan is mainly Late Palaeozoic, with a major age peak at 300 ± 3 Ma and secondary age peaks at 356 ± 7 Ma and 475 ± 10 Ma. The provenance mainly comes from the magmatic arc source area, and Early Palaeozoic (500–420 Ma) detrital zircons mainly come from the south‐east margin of Jiamusi Massif, Late Palaeozoic (400–270 Ma) detrital zircons mainly come from the eastern margin of Jiamusi Massif and the northern margin of Khanka Massif. Among them, detrital zircons of a special age group 330–310 Ma come from the north of Khanka Massif, while 490–470 Ma detrital zircons which are common in the Early‐Middle Permian strata of Khanka Massif come from Jiamusi Massif. Combined with the evidence of petrology and palaeontology, this paper believes that the Early Permian Jiamusi Massif and Khanka Massif should be a unified Massif, that is, Jiamusi‐Khanka Massif. [ABSTRACT FROM AUTHOR]

Freshwater aquaculture has a long and vibrant tradition in China. The Chinese longsnout catfish (Leiocassis longirostris) is a popular economic freshwater fish native to China. Understanding the genetic structure of L. longirostris populations is important for ensuring the efficacy of management practices and the sustainability of future increases in production. In this study, we used Illumina sequencing technology to isolate 20 novel polymorphic microsatellites from the genome of L. longirostris. These microsatellites were used to analyze the genetic diversity of 240 L. longrostris individuals from four populations. Genetic diversity parameters (NA, HO, HE, I, PIC, and FST) of the four farmed L. longirostris populations were analyzed. The level of genetic differentiation among the four farmed L. longirostris populations (inferred by pairwise comparisons of FST values) was low, but the genetic diversity of these populations was high, indicating that they still provide useful sources of genetic variation that could aid in breeding efforts. The STRUCTURE and ADMIXTURE analyses indicated that admixture might be occurring in the four L. longirostris populations, especially between the MS and YB populations. Understanding the genetic diversity of farmed L. longirostris populations and inbreeding prevention could greatly aid in breeding and production. These newly isolated microsatellite markers and the high genetic diversity of L. longirostris populations in the main breeding areas have important implications for the breeding and stock management of L. longirostris. [ABSTRACT FROM AUTHOR]

Business model innovation has become a necessary means for enterprises to break through path constraints, achieve sustainable development, and obtain sustainable competitiveness, which has been paid more and more attention by entrepreneurs and scholars. Based on the resource conversation theory and signal theory, this study constructs a research model with psychological capital (PC) and social capital (SC) as independent variables and business model innovation as dependent variables along the logical path of "resource acquisition-resource utilization." By dividing business model innovation into pioneering business model innovation and perfect business model innovation, we use fuzzy-set qualitative comparative analysis (fsQCA) to explore the impact of dual capital on business model innovation of new ventures. This study takes entrepreneurs from the eastern part of China's seven entrepreneurship active provinces as investigation objects, based on the analysis of the collected 242 valid questionnaire results, emphasizing that any single antecedent can not be a sufficient and necessary condition for pioneering and perfect business model innovation. In this case, we carried out research with a certain antecedent variable as the core and supplemented with other antecedent variables to form seven different configurations. The results showed that the combination of the antecedent variables could effectively achieve the pioneering and perfect business model innovation. The theoretical contributions of this study are as follows: (1) it enriches the research on the antecedents of business model innovation in new ventures; (2) it expands the application scenarios of resource conversation theory and signal theory; and (3) it is emphasized that the innovation of business model of new ventures is the result of the interaction and value-added linkage of various internal and external resources. [ABSTRACT FROM AUTHOR]

Drought seriously restricts people's lives and social–economic development. An accurate understanding of the evolution of drought characteristics and future changes in cultivated land exposure can reduce the risk of drought. There is evidence that increased CO2 concentrations alter the physiological properties of vegetation and, thus, affect drought evolution. In this study, both changes and differences in drought (i.e., characteristics and cropland exposure) with and without the CO2 effect over the arid region of China are investigated, using seven CMIP6 outputs and land-use under seven shared-socioeconomic-pathway (SSP)-based scenarios. The results show that: (1) drier conditions will be more severe in 2015–2100 under SSP5-8.5, especially if the CO2 effect is neglected. Moreover, the CO2 effect will increase with increasing emission concentrations; (2) drought intensity will be greater than in the baseline period (1995–2014, approximately −1.45) but weaker than that without the CO2 effect under all scenarios; (3) drought frequency will decrease, and will generally decline faster if the CO2 effect is not considered; (4) drought duration will increase and the difference between the presence and absence of the CO2 effect will always be smallest under SSP1-1.9 and largest under SSP5-8.5; (5) drought acreage will also increase, and neglecting the CO2 effect is always higher than that considering CO2. The difference between the two algorithms will increase with time; and (6) cropland exposure to drought will increase, and can even reach 669,000 km2 and 524,000 km2 considering and ignoring the CO2 effect, respectively. Our findings suggest that ignoring CO2 in drought evaluations will result in significant overestimations of drought projections. [ABSTRACT FROM AUTHOR]

Background: The prevalence of diabetes mellitus remains high in China, and more cardiovascular and cerebrovascular adverse events due to diabetes mellitus are likely to occur in the future. Objective: To analyze the gap between the current pharmacotherapy management and the guidelines for inpatients with type 2 diabetes mellitus from the perspective of pharmacists so as to provide a reference for optimal pharmacotherapy management methods and models for patients with type 2 diabetes mellitus. Methods: The study was a cross-sectional observational study. The study was conducted by investigating and analyzing the use of glucose-lowering drugs, adjustment of blood pressure management strategy, lipid management, weight management, and application of antiplatelet drugs in type 2 diabetes inpatients. Results: A total of 1086 patients with type 2 diabetes were included. Metformin, glycosidase inhibitors, and basal insulin were the most used among type 2 diabetes inpatients. The use of SGLT-2, GLP-1 RAs, DPP-4, and metformin all showed significant increase. SGLT-2 inhibitors (SGLT-2i) showed the fastest increase from 2020 to 2021 (14.5% vs. 39.6%); However, the application rate of SGLT-2i was low among patients with combined ASCVD, renal insufficiency, and diabetic nephropathy (46.4%, 40.9%, and 45.8% respectively). For patients with substandard blood pressure at admission, the average rate of intervention by endocrinologists for adjusting the antihypertensive regimen during hospitalization was 55.6%, and the application rate of ACEI/ARB drugs reached 64.4%. The application rate of statins among patients with type 2 diabetes was still relatively high, at 78.8%. However, the overall intervention rate for patients with suboptimal LDL-c was only 24.1%. The application rate of antiplatelet agents for patients with ASCVD was 77.6%, which was higher than that for patients without ASCVD. Conclusion: There is still a gap between the practice of medication treatment management of Chinese inpatients with type 2 diabetes and the guidelines, especially in the application of GLP-1RAs and SGLT-2i in patients with concomitant ASCVD, diabetic nephropathy, and renal insufficiency. Meanwhile, physicians and pharmacists should pay more attention on achieving blood pressure and LDL-c standards in type 2 diabetic patients and provide timely interventions. [ABSTRACT FROM AUTHOR]

Multi-criteria decision making (MCDM) is a sub-discipline of operations research aimed at evaluating alternatives in consideration of various criteria. It is used by practically everyone in their daily lives and professional settings. Seeing the great value of MCDM, we conduct a comprehensive review to propel its innovation and development forward. Compared with any other reviews, we do not focus on introducing its methods, but on tracing its evolution and characteristics. As a general rule, every discipline has its own developing laws. They can be understood on various levels and can point out the direction the discipline is heading for. We firmly believe that our work can bring insight into MCDM's frontiers and trend, which can eventually provide guidance on how to conduct the future research. In the first half of the paper, we investigate MCDM's paradigm through literature review and colloquially divide its story into four stages: the Stone Age, the Iron Age, the Industrial Age and the New Stage. The first three stages symbolise its debut, growth and prosperity. Each one has distinctive thoughts, techniques and application, and to some extent hints the major works of the next stage. Since the turn of the 21st century, the paradigm has been once again experiencing dramatic changes, suggesting that it is on the threshold of a new era. Thus, in the second half of the work, a bibliometric analysis of the present stage ensues. Put simply, we take a global view of the stage by visualizing the stage's publication quantity, publication distribution, and research categories. Then we design a snowballing co-citation method to explore its movements. The results demonstrate that MCDM is a dynamic, worldwide study for which China is the most productive country and the USA plays a pivot role in scholar communication. Method reviews, straightforward methods and MCDM-oriented fuzzy sets are predominant frontiers. The application, however, always changes with the requirements of the times. Now, it mainly refers to energy, environment, and supplier selection, while issues like sociology, tourism, education, etc. also emerge at a fast speed. Apart from this, experts have gradually shaken off the fetters of the traditional research style and are increasingly willing to structure methods and select application areas with a more personal touch. In the future, how to improve reviews, methods and fuzzy sets, how to understand and draw inspirations from society needs, and how experts can tailor MCDM to accommodate specific problems might be the pressing concerns. [ABSTRACT FROM AUTHOR]

The development of smart city is of strategic significance to the realization of modern society in China, and rail transit network is an important part of urban development. Currently, China's urban rail transport is at the bottleneck stage, and many medium-sized cities are facing a sudden heavy passenger congestion situation. Based on the next-generation innovation of the knowledge society, smart cities will maximize the use of new generation information technology in all fields of the city, and realize advanced urban informatization that realizes deep integration of informatization, industrialization, and informatization and helps to reduce urbanization and "disease in big cities." Improve the quality of urbanization, realize refined and dynamic management, and enhance the effectiveness of urban management and improve the quality of life of citizens. In order to ensure the safety of passengers, passenger flow control and optimization and upgrading of rail transit network become urgent. However, there are few researches in this field in China, so this paper will focus on the characteristics of sudden passenger flow and congestion control based on smart city rail transit network. First, in this paper, we systematically explained the relationship between smart cities and smart transportation and analyzed the need for sudden passenger flow control in urban railway transportation according to its characteristics. According to a study on the characteristics of sudden passenger flow, this paper believes that passenger flow comes primarily from large-scale activities, commuters, and individual emergencies, but is still predictable and controllable. For this reason, this paper studies the control scheme of sudden passenger flow congestion, which fully combines the characteristics of sudden passenger flow, and according to the characteristics of the treatment. This scheme is safe and reliable and has the advantage of controlling congestion from the source. In order to further test the actual effect of the passenger flow control scheme, the simulation experiment is carried out in the end of this paper. According to experimental data analysis, the passenger flow control method of this paper can effectively improve the existing rail transport congestion control in the case of sudden large-scale passenger flow, and the effect is remarkable, and most of them. Suitable for urban rail transport networks. [ABSTRACT FROM AUTHOR]

At present, China has accelerated the process of urban development that has led to a significant increase in the number of urban cars. The construction of basic transportation facilities has been unable to meet people's basic needs, and serious vehicle congestion has occurred on urban roads and expressways. Moreover, with the rapid increase of vehicles and the rapid development of industry, the harmful gases emitted pose a direct threat to the ecological environment. There is a dire need to vigorously promote the development of new energy vehicles based on this environment. All together, the miniaturization of sensor network, low power consumption, and low investment cost have become the preferred equipment for intelligent collection of traffic data. This article utilizes the sensor networks to study the speed coordination control of hybrid vehicle flow. It deploys the sensor nodes in roadside parking positions and driving sections of expressway. It also collects and fuses the data passing through sensor network nodes. Various algorithms in hybrid vehicle flow rate algorithm based on sensor networks are combined with the established speed flow relationship model of mixed vehicle flow. The actual highway road traffic situation is analyzed that can be used as an important basis to realize the coordinated control of mixed vehicle flow speed. The research shows that the average speed of expressway calculated based on quadratic parabola model is 83.72 km/h that has a deviation of 0.6% compared with the actual situation. [ABSTRACT FROM AUTHOR]

Potential evapotranspiration (PET) is an important factor that needs to be considered in regional water management and allocation; thus, the reasonable estimation of PET is an important topic in hydrometeorology and other related fields. There is evidence that increased CO2 concentration alters the physiological properties of vegetation and thus affects PET. In this study, changes in PET with and without the CO2 effect over China is investigated using seven CMIP6-GCMs outputs under seven shared socioeconomic pathways (SSPs) based scenarios (SSP1-1.9, SSP1-2.6, SSP2-4.5, SSP3-7.0, SSP4-3.4, SSP4-6.0, and SSP5-8.5), as well as the contribution rate of CO2 on PET in different climatic regions. Changes in estimated PET based on modified Penman–Monteith (PM) method that considers the CO2 effect is compared with the traditional PM method to examine how PET quantity varies (differences) between these two approaches. The results show that the PET values estimated by the two methods explored opposite trends in 1961–2014 over entire China; it decreases with consideration of CO2 but increases without consideration of CO2. In the future, overall PET is projected to increase under all scenarios during 2015–2100 for China and its three sub-regions. PET generally tends to grow slower when CO2 is taken into account (modified PM approach), than when it is not (traditional PM method). In terms of differences in the estimated PET by the two methods, the difference between the two adopted methods increased in China and its sub-regions for the 1961–2014 period. In the future, the difference in estimated PET is anticipated to continuously increase under SSP3-7.0 and SSP5-8.5. Spatially, a much greater extent of difference is found in the arid region. Across the arid region, the PET difference is projected to be the highest at 138% in the mid-term (2041–2060) with respect to the 1995–2014 period, whereas it tends to increase slower in the long-term period (2081–2100). Importantly, CO2 is found to be the most dominant factor (−154.2% contribution) to have a great effect on PET changes across the arid region. Our findings suggest that ignorance of CO2 concentration in PET estimation will result in significant overestimation of PET in the arid region. However, consideration of CO2 in PET estimation will be beneficial for formulating strategies on future water resource management and sustainable development at the local scale. [ABSTRACT FROM AUTHOR]

Objective: Investigating the mental health status of Chinese resident physicians during the 2019 new coronavirus outbreak. Methods: A cluster sampling method was adopted to collect all China-wide resident physicians during the epidemic period as the research subjects. The Symptom Checklist-90 self-rating scale was used to assess mental health using WeChat electronic questionnaires. Results: In total, 511 electronic questionnaires were recovered, all of which were valid. The negative psychological detection rate was 93.9% (480/511). Among the symptoms on the self-rating scale, more than half of the Chinese resident physicians had mild to moderate symptoms of mental unhealthiness, and a few had asymptomatic or severe unhealthy mental states. In particular, the detection rate of abnormality was 88.3% (451/511), obsessive-compulsive symptoms was 90.4% (462/511), the sensitive interpersonal relationship was 90.6% (463/511), depression abnormality was 90.8% (464)/511), anxiety abnormality was 88.3% (451/511), hostility abnormality was 85.3% (436/511), terror abnormality was 84.9% (434/511), paranoia abnormality was 86.9% (444/511), psychotic abnormalities was 89.0% (455/511), and abnormal sleeping and eating status was 90.8% (464/511). The scores of various psychological symptoms of pediatric resident physicians were significantly lower than those of non-pediatrics (p < 0.05). Conclusion: The new coronavirus epidemic has a greater impact on the mental health of Chinese resident physicians. [ABSTRACT FROM AUTHOR]

Rockburst is a severe geological hazard that restricts deep mine operations and tunnel constructions. To overcome the shortcomings of widely used algorithms in rockburst prediction, this study investigates the ensemble trees, i.e., random forest (RF), extremely randomized tree (ET), adaptive boosting machine (AdaBoost), gradient boosting machine, extreme gradient boosting machine (XGBoost), light gradient boosting machine, and category gradient boosting machine, for rockburst estimation based on 314 real rockburst cases. Additionally, Bayesian optimization is utilized to optimize these ensemble trees. To improve performance, three combination strategies, voting, bagging, and stacking, are adopted to combine multiple models according to training accuracy. ET and XGBoost receive the best capabilities (85.71% testing accuracy) in single models, and except for AdaBoost, six ensemble trees have high accuracy and can effectively foretell strong rockburst to prevent large-scale underground disasters. The combination models generated by voting, bagging, and stacking perform better than single models, and the voting 2 model that combines XGBoost, ET, and RF with simple soft voting, is the most outstanding (88.89% testing accuracy). The performed sensitivity analysis confirms that the voting 2 model has better robustness than single models and has remarkable adaptation and superiority when input parameters vary or miss, and it has more power to deal with complex and variable engineering environments. Eventually, the rockburst cases in Sanshandao Gold Mine, China, were investigated, and these data verify the practicability of voting 2 in field rockburst prediction. [ABSTRACT FROM AUTHOR]

Quinoa panicle rot (QPR) is a novel disease that poses a significant threat to quinoa production in China. Typical symptoms on panicles include a film of pale pink, grey‐white, or dark brown mould on the grains during the grain‐filling stage. Furthermore, QPR causes quinoa grain discolouration, unfilling, and malformation. In total, 37 isolates were identified as belonging to three species: Trichothecium roseum (nine isolates), Alternaria alternata (12), and Fusarium citri (16) based on morphology, and phylogenetic and pathogenicity characterization. The present study shows for the first time that T. roseum, A. alternata, and F. citri are the pathogens responsible for QPR. An evaluation of the growth and germination rates revealed a significant difference among the three species, with T. roseum and F. citri isolates having higher fitness in warmer (25–30℃) and humid conditions (water activity ≥0.98). However, A. alternata preferred cooler (20–25℃) and more arid conditions, and germinated in a wide range of water activities (water activity of 0.90–1.00). Among the three species, T. roseum and F. citri are probably responsible for the pink and grey diseased grains in humid regions, and A. alternata for the black‐brown diseased grains in arid regions. Pathogenicity tests showed that all three species could infect the quinoa panicles. The results of this study provide a basis for the recognition and management of QPR. [ABSTRACT FROM AUTHOR]