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Co-abatement strategies that can reduce both CO 2 and air pollutants emissions are essential for the green and low-carbon transition of China's iron and steel industry. Most previous studies analyzed CO 2 and air pollutants reduction policies independently, but the synergies and tradeoffs between the two types of policies have rarely been investigated. By establishing a bottom-up simulation model that considers combinations of different policy objectives, crude steel demand and technology development options, this study couples air pollutants reduction into the carbon neutrality pathways to evaluate the synergistic effects of different abatement strategies in China's iron and steel industry. The study also incorporates the indirect CO 2 and air pollutants emissions from the upstream energy production sectors into pathway analysis, in order to avoid cross-sectoral carbon and air pollution leakages. The results show that the current emissions reduction policies in the iron and steel industry are far from achieving the carbon neutrality goals. To achieve synergistic reduction in CO 2 and air pollutants emissions, the short term policies should mainly rely on increasing the share of the scrap-electric arc furnace (EAF), while reducing crude steel demand and promoting breakthrough technologies, particularly hydrogen-based direct reduction, should play a major role in the long term. Meanwhile, China should promote the decarbonization of power generation and hydrogen production to reduce indirect CO 2 and air pollutants emissions from the upstream sectors. [Display omitted] • Explore pathways for CO 2 and air pollutants co-abatement in iron and steel industry. • Evaluate contributions and synergistic effects of different abatement strategies. • Stronger policy measures are needed to achieve carbon neutrality target. • Decarbonization of upstream energy sectors is critical to reduce indirect emissions. • Material efficiency and structural adjustment have greater synergistic effects. [ABSTRACT FROM AUTHOR]

Background: Pseudorabies virus (PRV) causes Aujeszky's disease or pseudorabies (PR) in pigs worldwide, which leads to heavy economic losses to the swine industry. Pigs are the natural host, meanwhile, animals such as dogs, cats, foxes, rabbits, cattle and sheep are susceptible to infection. In 2011, the emerging PRV variant led to the outbreak of PR in Bartha-K61 vaccinated pigs. The PR outbreaks demonstrated that the Bartha-K61 vaccine did not provide full protection against the emerging PRV variant. It is widely believed that PRV live attenuated vaccine could control PRV infection. Methods: In this study, we developed a novel PRV live attenuated vaccine by deleting its gI, gE, US9, and US2 genes through CRISPR/Cas9, which was named PRV GDFS-delgI/gE/US9/US2. Results: Safety experiments confirmed that PRV GDFS-delgI/gE/US9/US2 was safe for 5- to 7-day-old suckling piglets. Piglets immunized with the PRV GDFS-delgI/gE/US9/US2 vaccine did not produce PRV gE-specific antibodies but could generate PRV gB-specific antibodies and high neutralizing titers against the PRV GDFS strain (variant PRV strain) or PRV Ea strain (older PRV strain). After challenge with the emerging PRV GDFS variant, none of the piglets immunized with the PRV GDFS-delgI/gE/US9/US2 vaccine showed any clinical signs, and their rectal temperatures were normal. Moreover, the autopsy and histopathological analyses revealed that the piglets in the PRV GDFS-delgI/gE/US9/US2 vaccine group did not show apparent gross or pathological lesions. Furthermore, the piglets in the PRV GDFS-delgI/gE/US9/US2 vaccine groups did not present weight loss. According to the criteria of the OIE terrestrial manual, the results of the experiment confirmed that the PRV GDFS-delgI/gE/US9/US2 vaccine could provide full protection against the emerging PRV variant strain in piglets. Conclusions: The PRV GDFS-delgI/gE/US9/US2 strain is a potential new live attenuated vaccine against emerging PRV variant strain infections in China. [ABSTRACT FROM AUTHOR]

Background: Chinese Herbal Medicines (CHMs), as an important and integral part of a larger system of medicine practiced in China, called Traditional Chinese Medicine (TCM), have been used in stroke therapy for centuries. A large body of studies suggest that some Chinese herbs can help reverse cognitive impairment in stroke patients, while whether these herbs also exert therapeutic benefits for Alzheimer's disease remains to be seen.Objective: To address this issue, we selected four types of CHMs that are commonly prescribed for stroke treatment in clinical practice, namely DengZhanXiXin (D1), TongLuoJiuNao (T2), QingKaiLing (Q3), and HuangQinGan (H4), and tested their effects on amyloid-β protein precursor (AβPP) processing in vitro.Methods: AβPP, β-secretase (BACE1), and 99-amino acid C-terminal fragment of AβPP (C99) stably transfected cells were used for the tests of AβPP processing. The production of Aβ, activity of BACE1, neprilysin (NEP), and γ-secretase were assessed by ELISA, RT-PCR, and western blot.Results: By upregulating BACE1 activity, D1 increased Aβ production whereas decreased the ratio of Aβ42/Aβ40; by downregulating BACE1 activity and modulating the expression of γ-secretase, T2 decreased Aβ production and the ratio of Aβ42/Aβ40; by downregulating BACE1 activity, Q3 decreased Aβ production; H4 did not change Aβ production due to the simultaneously downregulation of BACE1 and NEP activity.Conclusion: Our study indicates that these four anti-stroke CHMs regulate AβPP processing through different mechanisms. Particularly, T2 with relatively simple components and prominent effect on AβPP processing may be a promising candidate for the treatment of AD. [ABSTRACT FROM AUTHOR]

Apple stem grooving virus ( ASGV) is one of the economically important latent viruses that are distributed in apple production areas worldwide. The presence of ASGV in apple trees was studied by serological assay and molecular biology methods. A total of 550 apple leaf samples from 14 different areas in Shaanxi were tested by DAS- ELISA, and the results revealed an ASGV infection level of 55%. Those samples were also examined by RT- PCR, and an infection level of 67% was found. Fourteen complete coat protein gene sequences of ASGV were obtained; phylogenetic analysis revealed that these 14 sequences separated into two clusters regardless of the geographic origin or host plants. To our knowledge, this is the first report of molecular variability analysis of ASGV in apple trees in China. [ABSTRACT FROM AUTHOR]

The objective is to compare Multi-detector CT angiography (MDCTA) and digital subtraction angiography (DSA) in diagnosing hemodialysis catheter related-central venous stenosis (CVS). During a period of 6 years, hemodialysis patients with suspected catheter related-CVS who received both MDCTA and DSA were retrospectively enrolled. We analyzed the sensitivity, specificity, accuracy, Cohen's kappa coefficient (κ) and other diagnostic parameters for MDCTA compared to DSA. A total of 1533 vascular segments in 219 patients were analyzed. Among the 280 lesions identified by DSA, 156 were correctly identified by MDCTA. There were 124 false negative and 41 false positive diagnoses. MDCTA had a high specificity (96.73%) but a low sensitivity (55.71%), with a moderate inter-test agreement (κ = 0.5930). In stratified analyses of vascular segments, the specificities of MDCTA were 89.93% (superior vena cava), 98.95% (left brachiocephalic vein), 95.33% (right brachiocephalic vein), 99.53% (left subclavian vein), 97.61% (right subclavian vein), 97.13% (left internal jugular vein), and 95.86% (right internal jugular vein), while the sensitivities were 90.00%, 65.52%, 66.67%, 87.50%, 40.00%, 20.00% and 8.11%, respectively. Good to excellent inter-test agreement was observed for the superior vena cava (κ = 0.7870), left brachiocephalic vein (κ = 0.7300), right brachiocephalic vein (κ = 0.6610), and left subclavian vein (κ = 0.8700) compared with poor to low agreement for the right subclavian vein (κ = 0.3950), left internal jugular vein (κ = 0.1890), and right internal jugular vein (κ = 0.0500). MDCTA had a high specificity in diagnosing hemodialysis catheter related-CVS. Its sensitivity varied by central venous segments, with better performance in superior vena cava and brachiocephalic veins. [ABSTRACT FROM AUTHOR]

Zigui Basin is a major landslide-prone region in the Three Gorges Reservoir region of China, and the stabilizing pile is an effective and widely employed countermeasure to reinforce landslides in this region. However, stabilizing piles are mostly designed using deterministic and stability-oriented methods, which generally ignore the system performance and cost-effectiveness. Using the Majiagou landslide reinforced with stabilizing piles as a case study, a probabilistic multi-objective optimization framework for the design of stabilizing piles is proposed and illustrated. Specifically, performance objectives related to failure probability, system robustness and life-cycle cost of the landslide-stabilizing pile system with feasible designs are evaluated, then the best compromised design is obtained by means of Pareto optimality. Expert knowledge and professional judgment are required to set necessary restrictions and finally determine the optimal design. The results show that there is a better design of stabilizing piles than the existing one, with which acceptable reinforcement effectiveness, compromised life-cycle cost and robust system performance can be realized. The optimal design will also vary with the concerned performance objectives and knowledge-based judgment. Further relationships and interpretations between design parameters and system responses are discussed through parametric analyses. [ABSTRACT FROM AUTHOR]

To priority areas for conservation in the coast of Zhejiang, this study attempts to map the spatial patterns of the intra-specific genetic diversity of two intertidal species, Septifer virgatus and Tetraclita japonica, using the sequences of mitochondrial DNA cytochrome oxidase subunit I (COI) and large subunit ribosomal RNA (16S rRNA) genes. In total, 129 and 112 specimens were collected from 12 and 11 populations for S. virgatus and T. japonica, respectively. These two species revealed congruent population historical signals, including (1) high levels of haplotype diversity and low values of nucleotide diversity, (2) post-LGM expansion, (3) the lack of population genetic structure, sharing haplotypes over all sampling populations, (4) gene flow connections, and (5) migration directions. Largely, all results supported that all sampling populations could be divided into two main metapopulations, exhibiting a northern and southern distribution. The north metapopulation could be considered as a marine protected area. The genetic patterns of the two species should be considered in the management and conservation in the islands along the Zhejiang, China. [ABSTRACT FROM AUTHOR]

Objective: To assess the incidence and risk factors of hypoglycemia in hospitalized neonates in China. Methods: Blood glucose level in hospitalized neonates was monitored routinely. Also, in high-risk newborns and neonates with abnormal blood glucose levels in initial detection, the blood sugar level was monitored daily until it was back to normal and stable. Results: Hypoglycemia was detected in 113 out of 668 hospitalized neonates, and the incidence of hypoglycemia was 16.9%. The statistical analysis also showed that hypoglycemia always occurred within one week after birth, especially within three days after birth. Conclusion: Neonates with premature birth, low birth weight and perinatal asphyxia were susceptible to hypoglycemia. Active and continuous monitoring of blood glucose level should be performed in the early newborns, especially in high-risk children, and attention should be paid to timely feeding for the early diagnosis and treatment of neonatal hypoglycemia to reduce its impact on the newborns. [ABSTRACT FROM AUTHOR]

• Malan loess is anisotropic and it behaves strongly in vertical direction. • Malan loess under in-situ situation tends to fail at high rupture angles. • The anisotropy is in good agreement with the vertiloess structure. • The anisotropy favors deep vertical cracks which mobilize toppling and falling failures. • These failures shape the loess mass into columns and walls. Loess is widely distributed in China, with the Loess Plateau having the largest global bulk accumulation. The micro-scale loess landforms are featured by loess walls and loess columns, which can stand vertically for many years. The main failure modes of loess to form these vertical features are toppling and falling along a rupture surface of high angles. These failure modes are attributed to loess strength behavior, which in turn are dominated by the inner structure of loess soil. Bearing this in mind, we sought to conduct a series of mechanical tests on both vertical and horizontal loess samples. These included tension as well as uniaxial and triaxial compression tests. It is found that Malan loess had strong anisotropy in terms of failure pattern and strength. The vertical specimens possess strengths 1.3 times greater than those of horizontal specimens, and tend to fail at high rupture angles of approximately 85° under uniaxial and triaxial compression conditions. These findings were in good agreement with the vertiloess structure, where the vertically aligned strong units resulting from inter-particle bonding and close compaction make the loess behave strongly in the vertical direction, while the vertically aligned weak segments are responsible for the high rupture angles. These findings explain the formation of deep vertical cracks which mobilize loess toppling and falling and shape the loess mass into columns and walls. [ABSTRACT FROM AUTHOR]