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As one of the leading technologies for chemical enhanced oil recovery (cEOR), surfactant–polymer (SP) flooding technology has long attracted the interest of petroleum scientists and engineers. However, most of its application scenarios are based on the five-spot well pattern. The EOR potential in an inverted seven-spot well pattern is seldom ever recorded. The applicability of the SP system in the inverted seven-spot well pattern was examined based on the physical characteristics of Karamay Oilfield in China. The numerical simulation and the one-dimensional core flooding experiment were used to compare the sweep intensities and EOR abilities of the two well patterns. The migration law and the EOR ability of the SP system were assessed by a specially made one-third inverted seven-spot configuration. The main controlling factors and compatibility charts of SP flooding development in the inverted seven-spot well pattern were obtained. Results show that 61% of the region is represented by a weak swept state in the inverted seven-spot well pattern. The effective swept area is greatly increased by appropriately raising the viscosity and slug size of the SP system. Compared to constant viscosity injection, step-down viscosity injection further increases the sweep range and oil recovery. The inverted seven-spot well pattern has a greater swept area of the SP system than the five-spot one, but a weaker strength. Polymer concentration is the most effective factor of SP flooding in the inverted seven-spot well pattern, followed by oil viscosity and surfactant concentration. The study can broaden the application of the SP system in the inverted seven-spot well pattern. [ABSTRACT FROM AUTHOR]