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We established a new laboratory for noble gas mass spectrometry that is dedicated to the development and application to cosmogenic nuclides at the University of Cologne (Germany). At the core of the laboratory are a state-of-the-art high-mass-resolution multicollector Helix MC Plus (Thermo Fisher Scientific) noble gas mass spectrometer and a novel custom-designed automated extraction line. The mass spectrometer is equipped with five combined Faraday multiplier collectors, with 1012 and 1013 Ω preamplifiers for faraday collectors. We describe the extraction line and the automated procedure for cosmogenic neon and the current performance of the experimental set-up. Performance tests were conducted using gas of atmospheric isotopic composition (our primary standard gas), as well as CREU-1 intercomparison material, containing a mixture of neon of atmospheric and cosmogenic composition. We use the results from repeated analysis of CREU-1 to assess the performance of the current experimental set-up at Cologne. The precision in determining the abundance of cosmogenic 21Ne is equal to or better than those reported for other laboratories. The absolute value we obtain for the concentration of cosmogenic 21Ne in CREU is indistinguishable from the published value. [ABSTRACT FROM AUTHOR]