1. [Cost-effectiveness of risk-reducing salpingo-oophorectomy in cases of BRCA1 gene mutation in Colombia].
- Author
-
González-Mariño MA
- Subjects
- Colombia, Female, Genetic Markers, Hereditary Breast and Ovarian Cancer Syndrome economics, Hereditary Breast and Ovarian Cancer Syndrome genetics, Hereditary Breast and Ovarian Cancer Syndrome mortality, Humans, Markov Chains, Models, Economic, Mutation, Risk Reduction Behavior, Treatment Outcome, Cost-Benefit Analysis, Genes, BRCA1, Hereditary Breast and Ovarian Cancer Syndrome prevention & control, Prophylactic Surgical Procedures economics, Salpingo-oophorectomy economics
- Abstract
Objective: To assess the usefulness of risk reduction salpingo-oophorectomy in cases with mutation of the BRCA1 gene in Colombia., Material and Methods: Cost-effectiveness analysis in which three processes are incorporated: a. Patients with screening tests for breast and ovarian cancer. b. Risk reduction surgery in the fallopian tubes and ovaries c. Reductive surgery in the fallopian tubes and ovaries with bilateral mastectomy. The outcome is evaluated as the gain in years of survival., Results: The cohort with risk reduction surgery in the fallopian tubes and ovaries and bilateral mastectomy is the one with the highest gain with 13 years, while the risk reduction surgery in the fallopian tubes and ovaries gain 4.95 years with respect to the follow-up group., Conclusions: The three options evaluated are acceptable, but of them the one with the greatest gain in survival is the combination of risk-reducing surgery in the fallopian tubes and ovaries with bilateral mastectomy.
- Published
- 2018
- Full Text
- View/download PDF