1. New Δ -tocotrienol derivatives from Colombian propolis.
- Author
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Popova MP, Trusheva BS, Nedialkov PT, Tsvetkova I, Pardo-Mora DP, Najdenski H, Torres-García OA, Sforcin JM, and Bankova VS
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Benzopyrans analysis, Benzopyrans pharmacology, Candida albicans drug effects, Colombia, Microbial Sensitivity Tests, Molecular Structure, Staphylococcus aureus drug effects, Vitamin E chemistry, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Propolis chemistry, Vitamin E analogs & derivatives
- Abstract
Two new δ -tocotrienol derivatives with oxidized terminal chain: 5,6-dioxo-garcinoic acid ( trans -13'-carboxy-5,6-dioxo -δ -tocotrienol) ( 2 ) and 5-hydroxy-8b-oxo garcinoic acid ( trans -13'-carboxy-5-hydroxy-8b-oxo -δ -tocotrienol) ( 3 ), together with one known derivative garcinoic acid ( trans -13'-carboxy- δ -tocotrienol) ( 1 ) were isolated from a Colombian propolis. Garcinoic acid was found as a propolis constituent for the first time. The isolated compounds and crude ethanolic extract demonstrated high antimicrobial activity against Staphylococcus aureus and Candida albicans (MICs range: 10-39 μg/ml) as well as promising antioxidant potential in DPPH assay. Compound 3 displayed highest radical scavenging activity, even higher than that of dl- α -tocopherol, used as a positive control.
- Published
- 2020
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