1. The outpatient treatment of refractory hypertension with minoxidil.
- Author
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Kleiner JP, Ball JH, Nelson WP, and Norton JD
- Subjects
- Adult, Ambulatory Care, Antihypertensive Agents therapeutic use, Body Fluids drug effects, Colorado, Female, Furosemide pharmacology, Furosemide therapeutic use, Hirsutism chemically induced, Humans, Male, Middle Aged, Minoxidil adverse effects, Propranolol therapeutic use, Tachycardia chemically induced, Tachycardia drug therapy, Hypertension drug therapy, Minoxidil therapeutic use, Pyrimidines therapeutic use
- Abstract
Minoxidil is a potent orally administered vasodilator under investigation for use in severe hypertension. Fifteen patients with moderate to severe hypertension refractory to conventional antihypertensive drugs were treated with minoxidil on an outpatient basis. Propranolol and furosemide were administered concomitantly to control reflex tachycardia and fluid retention. Good blood pressure control was achieved in all but one patient with the average supine mean arterial blood pressure falling from 140 mm Hg with conventional drugs to 106 mm Hg with minoxidil (P less than 0.0005). The major side effects of fluid retention (9/15), hirsutism (15/15), and tachycardia were adequately controlled in all but one patient. We conclude that minoxidil will be a valuable drug in the outpatient management of refractory hypertension.
- Published
- 1977
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