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Psoriasis and vitiligo are very common skin disorders that may have a profound impact upon the affected individuals; the etiology of both diseases includes genetic factors and triggers, which could be endogenous or exogenous. Two groups of children population consisting of 153 patients suffering from skin disorder (65 with vitiligo and 88 with psoriasis) have been examined at the Department of Dermatovenerology, University Hospital Osijek, during three years period. Basic methods of data collection were: questionnaire, clinically examination and histological proven diagnosis. The aim of this investigation were to determine the most common triggers, which play a role at onset of disease among young patients with vitiligo and psoriasis, and to establish familial distribution among both groups of patients. The results of investigations showed that the onset of vitiligo was mostly connected with psychological factors (56.9%), but the most frequently trigger in childhood psoriasis was inflammatory focus (38.6%). According to morphologic patterns the authors separated two groups of patients among psoriatics: group I with plaque psoriasis, which pointed the inflammatory focus and physical trauma as trigger before onset of disease (each 25.0%) and group II with psoriasis guttata and inflammatory focus as trigger at even 62.5% cases. Familial distribution among psoriatic children was 55.6%, and among children with vitiligo only 16.9%. Ours children patients showed significantly disparity in structure of triggers according diagnosis and gender distributions and about familial occurrence. Also some difference has been established according to age of onset between psoriasis and vitiligo at early childhood.