1. A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.
- Author
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Kassa J, Misik J, and Karasova JZ
- Subjects
- Animals, Antidotes adverse effects, Atropine therapeutic use, Autonomic Nervous System drug effects, Autonomic Nervous System physiopathology, Chemical Warfare Agents chemistry, Chemical Warfare Agents toxicity, Cholinesterase Inhibitors chemistry, Cholinesterase Inhibitors toxicity, Cholinesterase Reactivators adverse effects, Czech Republic, Drug Therapy, Combination, Lethal Dose 50, Male, Muscarinic Antagonists therapeutic use, Neurons drug effects, Neurotoxicity Syndromes physiopathology, Obidoxime Chloride adverse effects, Oximes adverse effects, Psychomotor Performance drug effects, Pyridinium Compounds adverse effects, Rats, Rats, Wistar, Sarin toxicity, Antidotes therapeutic use, Cholinesterase Reactivators therapeutic use, Neurotoxicity Syndromes drug therapy, Obidoxime Chloride therapeutic use, Oximes therapeutic use, Pyridinium Compounds therapeutic use, Sarin antagonists & inhibitors
- Abstract
The neuroprotective effects of a newly developed oxime K203 and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with sarin were studied. The sarin-induced neurotoxicity was monitored using a functional observatory battery at 2 hr after sarin challenge. The results indicate that the potency of a novel bispyridinium oxime K203 to counteract sarin-induced neurotoxicity is relatively low and roughly corresponds to the neuroprotective efficacy of obidoxime. Among tested oximes, the oxime HI-6 seems to be significanlty more efficacious to counteract acute neurotoxicity of sarin than commonly used obidoxime and a newly developed oxime K203. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with sarin in comparison with the oxime HI-6 that should be considered to be the best oxime for antidotal treatment of acute sarin poisonings., (© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.)
- Published
- 2012
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