1. Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers.
- Author
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Buschard K, Kühl C, Mølsted-Pedersen L, Lund E, Palmer J, and Bottazzo GF
- Subjects
- Adolescent, Adult, Antibodies analysis, Autoantibodies analysis, Child, Child, Preschool, Cohort Studies, Denmark, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 1 epidemiology, Female, Follow-Up Studies, Humans, Immunoglobulin G analysis, Insulin immunology, Insulin therapeutic use, Pancreas cytology, Pregnancy, Pregnancy in Diabetics drug therapy, Pregnancy in Diabetics epidemiology, Prognosis, Diabetes Mellitus, Type 1 immunology, Fetus, Islets of Langerhans immunology, Pancreas embryology, Pregnancy in Diabetics immunology
- Abstract
55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.
- Published
- 1989
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