1. The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.
- Author
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Simpson BN, Mejía Sang ME, Collado Puello Y, Diaz Brockmans EJ, Díaz Soto MF, Rivera Defilló SM, Taveras Cruz KM, Santiago Pérez JO, Husami A, Day ME, Pilipenko V, Mena R, Mota C, Hostetter MK, Muglia LJ, Schlaudecker E, Gonzalez Del Rey J, Martin LJ, and Prada CE
- Subjects
- Humans, Child, Dominican Republic epidemiology, Cohort Studies, Genomics, Dengue diagnosis, Dengue epidemiology, Severe Dengue
- Abstract
We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation., (© The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2023
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