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Purpose To assess the ability of optic nerve head (ONH) parameters measured with 2 different imaging technologies to discriminate between normal and glaucoma patients with visual field losses. Methods Sixty‐seven normal eyes and 43 glaucoma patients were consecutive and prospectively selected. Participants were classified depending on the results of standard automated perimetry (SAP) and intraocular pressure. All of them underwent a comprehensive ophthalmic examination, at least 2 reliable SAP tests, and imaging of the ONH with the Heidelberg Retina Tomograph 3 (HRT; Heidelberg Engineering, Heidelberg, Germany) and with Cirrus OCT (Carl Zeiss Meditec, Dublin, Ca). Only one eye per subject was randomly included in the statistical analysis. The areas under the receiver operating characteristic curve (AUCs) were plotted and sensitivity‐specificity pairs compared. Results The mean age was 55.713.6 years for the normal group and 59.16.2 years for the glaucoma group (p=0.133). The mean deviation of SAP was ‐0.71.2 dB and ‐5.96.1 dB (p<0.001) for the normal and glaucoma groups, respectively. The largest AUCs were observed for the rim area of Cirrus (0.954; 95% confidence interval [CI]: 0.919‐0.989), and the vertical cup/disk ratio of HRT3 (0.924; 95% CI: 0.890‐0.959). There was not a significant difference between them. Sensitivity at 85% fixed specificity was 86% for the rim area of Cirrus and 83.7% for the cup/disk area ratio of HRT3. Conclusion ONH parameters measured with spectral‐domain OCT and HRT3 have similar diagnostic performance. OCT, however, does not require prior manual outlining of disc boundaries, reducing the dependency on operator skill. [ABSTRACT FROM AUTHOR]