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The aeolian loess blanketing the Chinese Loess Plateau (CLP) is sensitive to climate change in monsoonal East Asia. Here, we present a multi-proxy climatic record from a Pleistocene loess-paleosol sequence from the Lantian Basin on the southern margin of the CLP. The measurements include magnetic susceptibility and related magnetic properties, bulk median grain-size, color reflectance, and the color-inferred hematite versus goethite ratio (Hm/Gt). A long-term aridification and cooling trend during the interval from ca 2.22–0.43 Ma is indicated by two magnetic grain-size proxies, corresponding to the global climatic cooling of the late Cenozoic. In addition, at least four intervals of climatic extremes are evident in the record of Hm/Gt ratio: at 1.71–1.65 Ma, 1.26–1.24 Ma, 0.94–0.86 Ma, and 0.62–0.48 Ma. These intervals are characterized by distinct regional climates, which contrast with the global climatic conditions represented in marine sediments. For example, a relatively arid climate is documented from 1.71 to 1.65 Ma, which was rapidly succeeded by a relatively humid climate which is associated with the earliest hominin (with an age of ca 1.63 Ma) in the Lantian Basin. [ABSTRACT FROM AUTHOR]