1. Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia.
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Varga, Matthew G., Cai, Hui, Waterboer, Tim, Murphy, Gwen, Shimazu, Taichi, Taylor, Phil R., Qiao, You-Lin, Park, Sue K., Yoo, Keun-Young, Jee, Sun Ha, Cho, Eo Rin, Kim, Jeongseon, Abnet, Christian C., Tsugane, Shoichiro, Cai, Qiuyin, Zheng, Wei, Pawlita, Michael, Shu, Xiao-Ou, and Epplein, Meira
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EPSTEIN-Barr virus , *VIRAL antibodies , *STOMACH cancer risk factors , *PUBLIC health , *BIOMARKERS , *EPSTEIN-Barr virus diseases , *RESEARCH funding , *RISK assessment , *SERODIAGNOSIS , *STOMACH tumors , *TUMORS , *VIRAL antigens , *CASE-control method , *DIAGNOSIS - Abstract
Background: Epstein-Barr virus (EBV)-positive gastric cancers represent a distinct subtype of gastric cancers and account for nearly 10% of the gastric cancer burden, yet risk detection strategies for this cancer subtype are lacking.Methods: We conducted a nested case-control study where we assayed 4 EBV antigens [viral capsid antigen (VCA), early antigen (EA), Epstein-Barr nuclear antigen (EBNA), and BZLF1-encoded replication activator protein (ZEBRA)] in either sera or plasma from 1447 gastric cancer cases and 1797 controls obtained from seven prospective cohorts representing individuals from the high gastric cancer-risk countries of China, Japan, and Korea.Results: The prevalence of EBV sero-positivity was universal with the exception of one sero-negative individual, and the highest titers of the EBV antigens VCA (OR 0.95, 95% CI 0.78-1.17), EBNA (OR 0.88, 95% CI 0.72-1.08), EA (OR 0.97, 95% CI 0.79-1.19), and ZEBRA (OR 0.87, 95% CI 0.71-1.07) were not associated with risk of incident gastric cancer. When we stratified these data by H. pylori status, there was no change in the association.Conclusions: Multiplex serology of the aforementioned EBV antigens in serum may not be a suitable biomarker for predicting gastric cancer risk in East Asian populations. [ABSTRACT FROM AUTHOR]- Published
- 2018
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