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As the second-largest shifting sand desert worldwide, the Taklimakan Desert (TD) represents the typical aeolian landforms in arid regions as an important source of global dust aerosols. It directly affects the ecological environment and human health across East Asia. Thus, establishing a comprehensive environment and climate observation network for field research in the TD region is essential to improve our understanding of the desert meteorology and environment, assess its impact, mitigate potential environmental issues, and promote sustainable development. With a nearly 20-yr effort under the extremely harsh conditions of the TD, the Desert Environment and Climate Observation Network (DECON) has been established completely covering the TD region. The core of DECON is the Tazhong station in the hinterland of the TD. Moreover, the network also includes 4 satellite stations located along the edge of the TD for synergistic observations, and 18 automatic weather stations interspersed between them. Thus, DECON marks a new chapter of environmental and meteorological observation capabilities over the TD, including dust storms, dust emission and transport mechanisms, desert land–atmosphere interactions, desert boundary layer structure, ground calibration for remote sensing monitoring, and desert carbon sinks. In addition, DECON promotes cooperation and communication within the research community in the field of desert environments and climate, which promotes a better understanding of the status and role of desert ecosystems. Finally, DECON is expected to provide the basic support necessary for coordinated environmental and meteorological monitoring and mitigation, joint construction of ecologically friendly communities, and sustainable development of central Asia. [ABSTRACT FROM AUTHOR]