7 results on '"García, Héctor"'
Search Results
2. On the relationship between calcified neurocysticercosis and epilepsy in an endemic village: A large-scale, computed tomography-based population study in rural Ecuador.
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Del Brutto, Oscar H., Arroyo, Gianfranco, Del Brutto, Victor J., Zambrano, Mauricio, and García, Héctor H.
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DIAGNOSIS of epilepsy ,NEUROCYSTICERCOSIS ,COMPUTED tomography ,EPIDEMIOLOGY ,MAGNETIC resonance imaging of the brain ,RURAL population ,PUBLIC health ,DIAGNOSIS ,HEALTH - Abstract
Objective Using a large-scale population-based study, we aimed to assess prevalence and patterns of presentation of neurocysticercosis ( NCC) and its relationship with epilepsy in community-dwellers aged ≥20 years living in Atahualpa (rural Ecuador). Methods In a three-phase epidemiological study, individuals with suspected seizures were identified during a door-to-door survey and an interview (phase I). Then, neurologists evaluated suspected cases and randomly selected negative persons to estimate epilepsy prevalence (phase II). In phase III, all participants were offered noncontrast computed tomography ( CT) for identifying NCC cases. The independent association between NCC (exposure) and epilepsy (outcome) was assessed by the use of multivariate logistic regression models adjusted for age, sex, level of education, and alcohol intake. CT findings were subsequently compared to archived brain magnetic resonance imaging in a sizable subgroup of participants. Results Of 1,604 villagers aged ≥20 years, 1,462 (91%) were enrolled. Forty-one persons with epilepsy ( PWE) were identified, for a crude prevalence of epilepsy of 28 per 1,000 population (95% confidence interval [CI] = 20.7-38.2). A head CT was performed in 1,228 (84%) of 1,462 participants, including 39 of 41 PWE. CT showed lesions consistent with calcified parenchymal brain cysticerci in 118 (9.6%) cases (95% CI = 8.1-11.4%). No patient had other forms of NCC. Nine of 39 PWE, as opposed to 109 of 1,189 participants without epilepsy, had NCC (23.1% vs. 9.2%, p = 0.004). This difference persisted in the adjusted logistic regression model (odds ratio = 3.04, 95% CI = 1.35-6.81, p = 0.007). Significance This large CT-based study demonstrates that PWE had three times the odds of having NCC than those without epilepsy, providing robust epidemiological evidence favoring the relationship between NCC and epilepsy. [ABSTRACT FROM AUTHOR]
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- 2017
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3. SARS-CoV-2-related mortality in a rural Latin American population.
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Del Brutto, Oscar H., Costa, Aldo F., Mera, Robertino M., Recalde, Bettsy Y., Bustos, Javier A., and García, Héctor H.
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SARS-CoV-2 , *MORTALITY , *RESPIRATORY diseases , *OLDER people , *HERD immunity - Abstract
• There is no evidence on mortality rates of SARS-CoV-2 in remote rural settings. • We calculated SARS-CoV-2 mortality rate of adults living in Atahualpa (rural Ecuador). • SARS-CoV-2 mortality rate was 15.7/1,000, which increased to 68.9/1,000 when only older adults were considered. • Most deaths occurred over a two-month period, and markedly decreased subsequently. A sudden increase in adult mortality associated with respiratory diseases was noticed in Atahualpa (a rural Ecuadorian village), coinciding with the introduction of SARS-CoV-2 in the region. From a total of 1,852 individuals aged ≥18 years, 40 deaths occurred between January and June, 2020. In addition, a seroprevalence survey showed that 45% of the adult population have SARS-CoV-2 antibodies. Verbal autopsies revealed SARS-CoV-2 as the most likely cause of death in 29 cases. The mean age of suspected or confirmed SARS-CoV-2 cases was 76.9 ± 12.1 years, while that of those dying from unrelated causes was 60.3 ± 20.4 years (p = 0.003). The overall mortality rate was 21.6 per 1,000 population (95% C.I.: 15.9 – 29.2), almost three-quarters of it due to SARS-CoV-2 (15.7 per 1,000; 95% C.I.: 11 – 22.4). This configures a 266% of excess mortality when compared to 5.9 per 1,000 (95% C.I.: 3.3 – 10.6) deaths from other causes. When SARS-CoV-2 mortality rate was calculated in individuals aged ≥60 years, it raised up to 68.9 per 1,000 (95% C.I.: 47.8 – 98.4). After peaking in April and May, mortality significantly decreased. It is possible that the high proportion of infected individuals and the resulting herd immunity contributed to the observed reduction in mortality. [ABSTRACT FROM AUTHOR]
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- 2020
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4. SARS-CoV-2 in Rural Latin America. A Population-based Study in Coastal Ecuador.
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Del Brutto OH, Costa AF, Mera RM, Recalde BY, Bustos JA, and García HH
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- Adult, Ecuador epidemiology, Humans, Latin America, Rural Population, COVID-19, SARS-CoV-2
- Abstract
Antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were detected in 303/673 rural Ecuadorian adults (45%), 77% of whom had compatible clinical manifestations. Seropositivity was associated with the use of open latrines. Our findings support the fears of mass spread of SARS-CoV-2 in rural Latin America and cannot exclude a contributing role for fecal-oral transmission., (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
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- 2021
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5. Late incidence of SARS-CoV-2 infection in a highly-endemic remote rural village. A prospective population-based cohort study.
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Del Brutto OH, Costa AF, Mera RM, Recalde BY, Bustos JA, and García HH
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- Adult, Aged, Antibodies, Viral blood, COVID-19 blood, COVID-19 virology, COVID-19 Serological Testing, Cross-Sectional Studies, Ecuador epidemiology, Female, Humans, Incidence, Male, Middle Aged, Prospective Studies, Rural Population statistics & numerical data, SARS-CoV-2 genetics, SARS-CoV-2 physiology, Seroconversion, COVID-19 diagnosis, COVID-19 epidemiology, SARS-CoV-2 isolation & purification
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Data on SARS-CoV-2 transmission in rural communities is scarce or non-existent. A previous cross-sectional study in middle-aged and older adults enrolled in the Atahualpa Project Cohort demonstrated that 45% of participants had SARS-CoV-2 antibodies, 77% of whom were symptomatic. Here, we assessed the incidence of SARS-CoV-2 infection in the above-mentioned rural population. One month after baseline testing, 362 of 370 initially seronegative individuals were re-tested to assess incidence of seroconversion and associated risk factors. Twenty-eight of them (7.7%) became seropositive. The overall incidence rate ratio was 7.4 per 100 person months of potential virus exposure (95% C.I.: 4.7-10.2). Six seroconverted individuals (21.4%) developed SARS-CoV-2-related symptomatology. The only covariate significantly associated with seroconversion was the use of an open latrine. Predictive margins showed that these individuals were 2.5 times more likely to be infected (95% C.I.: 1.03-6.1) than those using a flushing toilet. Therefore, along one month, approximately 8% of seronegative individuals became infected, even after almost half of the population was already seropositive. Nevertheless, a smaller proportion of incident cases were symptomatic (21% versus 77% of the earlier cases), and no deaths were recorded. Whether this decreased clinical expression resulted from a lower viral load in new infections cannot be determined. Increased seroconversion in individuals using latrines is consistent with a contributory role of fecal-oral transmission, although we cannot rule out the possibility that latrines are acting as a proxy for poverty or other unknown interacting variables.
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- 2020
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6. Household Clustering of SARS-CoV-2 in Community Settings: A Study from Rural Ecuador.
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Del Brutto OH, Costa AF, Mera RM, Recalde BY, Bustos JA, and García HH
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- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral blood, COVID-19, Case-Control Studies, Child, Cluster Analysis, Ecuador epidemiology, Family Characteristics, Female, Humans, Immunoglobulin G blood, Immunoglobulin M blood, Male, Middle Aged, Pandemics, SARS-CoV-2, Young Adult, Betacoronavirus, Coronavirus Infections epidemiology, Pneumonia, Viral epidemiology
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The SARS-CoV-2 pandemic is now expanding into the developing world with devastating consequences. Departing from a population-based study in rural Ecuador where all adult individuals (aged 40 years or older) were tested for SARS-CoV-2 IgG and IgM antibodies, we expanded it to include a house-based case-control component assessing in-house clustering and other variables potentially associated with infection. We selected houses where exactly two study participants lived and were both seropositive (case-houses), and matched 1:1 to control-houses where both were seronegative. Younger household members had an antibody test performed. Infected household members were found in 33 (92%) case-houses and in only six (17%) control-houses. In 28/29 discordant house pairs, the case-house had seropositive household members and the control-house did not (odds ratio: 28; 95% CI: 4.6-1,144). Our data demonstrate strong in-house clustering of infection in community settings, stressing the importance of early case ascertainment and isolation for SARS-CoV-2 control.
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- 2020
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7. Incidence of human Taenia solium larval Infections in an Ecuadorian endemic area: implications for disease burden assessment and control.
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Coral-Almeida M, Rodríguez-Hidalgo R, Celi-Erazo M, García HH, Rodríguez S, Devleesschauwer B, Benítez-Ortiz W, Dorny P, and Praet N
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- Adult, Animals, Antibodies, Helminth blood, Antigens, Helminth blood, Cost of Illness, Cysticercosis prevention & control, Ecuador epidemiology, Endemic Diseases, Female, Humans, Incidence, Male, Seroepidemiologic Studies, Cysticercosis epidemiology, Cysticercosis parasitology, Taenia solium isolation & purification
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Background: Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology., Methodology/principal Findings: A seroepidemiological cohort study was conducted in a south-Ecuadorian community to estimate the incidence rate of infection with and the incidence rate of exposure to T. solium based on antigen and antibody detections, respectively. The incidence rate of infection was 333.6 per 100,000 person-years (95% CI: [8.4-1,858] per 100,000 person-years) contrasting with a higher incidence rate of exposure 13,370 per 100,000 person-years (95% CI: [8,730-19,591] per 100,000 person-years). The proportion of infected individuals remained low and stable during the whole study year while more than 25% of the population showed at least one antibody seroconversion/seroreversion during the same time period., Conclusions/significance: Understanding the transmission of T. solium is essential to develop ad hoc cost-effective prevention and control programs. The estimates generated here may now be incorporated in epidemiological models to simulate the temporal transmission of the parasite and the effects of control interventions on its life cycle. These estimates are also of high importance to assess the disease burden since incidence data are needed to make regional and global projections of morbidity and mortality related to cysticercosis.
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- 2014
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