1. Urban–rural differences in breast cancer incidence in Egypt (1999–2006).
- Author
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Dey, Subhojit, Soliman, Amr S., Hablas, Ahmad, Seifeldein, Ibrahim A., Ismail, Kadry, Ramadan, Mohamed, El-Hamzawy, Hesham, Wilson, Mark L., Banerjee, Mousumi, Boffetta, Paolo, Harford, Joe, and Merajver, Sofia D.
- Subjects
BREAST cancer risk factors ,RURAL-urban differences ,XENOESTROGENS ,EPIDEMIOLOGY of cancer ,CANCER in women - Abstract
Abstract: Objective: To describe urban–rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer. Methods: We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban–rural classification. Incidence patterns of breast cancer by district and age-specific urban–rural differences were analyzed. Results: Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/10
5 -year for urban areas versus 17.8/105 -year for rural areas; IRR=3.73, 95% CI=3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla. Conclusions: Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances. [ABSTRACT FROM AUTHOR]- Published
- 2010
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