1. Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells.
- Author
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Hamed AI, Plaza A, Balestrieri ML, Mahalel UA, Springuel IV, Oleszek W, Pizza C, and Piacente S
- Subjects
- Apoptosis drug effects, Drug Screening Assays, Antitumor, Egypt, Humans, Nuclear Magnetic Resonance, Biomolecular, Plant Roots chemistry, Sarcoma, Kaposi, Spectrometry, Mass, Electrospray Ionization, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Apocynaceae chemistry, Cardenolides chemistry, Cardenolides isolation & purification, Cardenolides pharmacology, Glycosides chemistry, Glycosides isolation & purification, Glycosides pharmacology, Plants, Medicinal chemistry
- Abstract
Continuing our investigations on plants belonging to the Asclepiadaceae family, three new cardenolide glycosides, 3'-O-beta-D-glucopyranosylcalactin (1), 12-dehydroxyghalakinoside (2), and 6'-dehydroxyghalakinoside (3), along with the known ghalakinoside (4) and calactin (5), were isolated from the roots of Pergularia tomentosa. The structures of these compounds were elucidated by extensive spectroscopic methods including 1D- and 2D-NMR experiments as well as ESIMS analysis. The isolated cardenolides caused apoptotic cell death of Kaposi's sarcoma cells.
- Published
- 2006
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