1. Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate.
- Author
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Shaala LA and Youssef DT
- Subjects
- Alkaloids chemistry, Alkaloids isolation & purification, Alkaloids pharmacology, Animals, Antibiotics, Antineoplastic chemistry, Antibiotics, Antineoplastic pharmacology, Antifungal Agents chemistry, Antifungal Agents isolation & purification, Antifungal Agents pharmacology, Aquatic Organisms isolation & purification, Aquatic Organisms microbiology, Azepines chemistry, Azepines pharmacology, Candida albicans drug effects, Candida albicans growth & development, Cell Line, Tumor, Cell Movement drug effects, Cell Proliferation drug effects, Culture Media, Conditioned chemistry, Egypt, Humans, Molecular Structure, Mycelium chemistry, Neoplasms pathology, Penicillium isolation & purification, Seawater microbiology, Stereoisomerism, Tropolone chemistry, Tropolone isolation & purification, Tropolone pharmacology, Urochordata growth & development, Antibiotics, Antineoplastic isolation & purification, Aquatic Organisms chemistry, Azepines isolation & purification, Drug Discovery, Neoplasms drug therapy, Penicillium chemistry, Tropolone analogs & derivatives, Urochordata microbiology
- Abstract
In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with the 1,4-diazepane skeleton, terretrione D (2), together with the known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and terretrione C (6), were isolated from Penicillium sp. CYE-87. The structures of the isolated compounds were established by spectral analysis, including 1D (1H, 13C) and 2D (COSY, multiplicity edited-HSQC and HMBC) NMR and HRESIMS, as well as comparison of their NMR data with those in the literature. The compounds were evaluated for their antimigratory activity against the human breast cancer cell line (MDA-MB-231) and their antiproliferation activity against HeLa cells. Compounds 2 and 6 showed significant antimigratory activity against MDA-MB-231, as well as antifungal activity against C. albicans.
- Published
- 2015
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