1. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry.
- Author
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Ramos-Araque ME, Siegler JE, Ribo M, Requena M, López C, de Lera M, Arenillas JF, Pérez IH, Gómez-Vicente B, Talavera B, Portela PC, Guillen AN, Urra X, Llull L, Renú A, Nguyen TN, Jillella D, Nahab F, Nogueira R, Haussen D, Then R, Thon JM, Esparragoza LR, Hernández-Pérez M, Bustamante A, Mansour OY, Megahed M, Hassan T, Liebeskind DS, Hassan A, Bushnaq S, Osman M, and Vazquez AR
- Subjects
- Adult, Aged, Aged, 80 and over, Brain Ischemia, COVID-19 blood, COVID-19 diagnostic imaging, COVID-19 mortality, Cohort Studies, Computed Tomography Angiography, Egypt epidemiology, Female, Fibrin Fibrinogen Degradation Products metabolism, Humans, Ischemic Stroke blood, Ischemic Stroke diagnostic imaging, Ischemic Stroke mortality, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Risk Factors, SARS-CoV-2, Spain epidemiology, Stroke, United States epidemiology, COVID-19 complications, Hospital Mortality, Ischemic Stroke virology, Registries
- Abstract
Background and Purpose: Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology., Methods: We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20)., Results: Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p
- Published
- 2021
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