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1. The novel agent pirfenidone attenuates the pro-fibrotic molecular environment generated by calcineurin-inhibitors in the rat salt-depletion model.

Author

Brook, N. R., Waller, J. R., Bicknell, G. R., and Nicholson, M. L.

Subjects
*RETROPERITONEAL fibrosis, *ANIMAL models in research, *DRUG development, *HOMOGRAFTS, *GRAFT rejection, *DRUG therapy, *RESEARCH
Abstract

Examines the use of the novel agent antifibrotic agent pirfenidone in rat salt-depleted model by researchers from Leicester, England. Role of the nephrotoxic effects of calcineurin inhibitor (CNI) immunosuppression in chronic renal allograft dysfunction on the loss of allograft; Efficacy of pirfenidone in attenuating the pro-fibrotic molecular environment created by CNI; Assertion from the researchers regarding the underlying mechanism of the action of pirfenidone.

Published
2004

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