1. The impact of freezing of gait on functional dependency in Parkinson's disease with regard to motor phenotype.
- Author
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Santos-García D, de Deus-Fonticoba T, Suárez Castro E, M Aneiros Díaz Á, Feal-Painceiras MJ, Paz-González JM, García-Sancho C, Jesús S, Mir P, Planellas L, García-Caldentey J, Caballol N, Legarda I, Hernández-Vara J, González-Aramburu I, Ávila-Rivera MA, Catalán MJ, Nogueira V, Álvarez-Sauco M, Vela L, Escalante S, Cubo E, Sánchez-Alonso P, Alonso-Losada MG, López-Ariztegui N, and Martinez-Martin P
- Subjects
- Aged, England, Female, Gait, Humans, Male, Middle Aged, Phenotype, Gait Disorders, Neurologic epidemiology, Parkinson Disease complications, Parkinson Disease drug therapy, Parkinson Disease epidemiology
- Abstract
Background and Objective: Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson's disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship with functional dependency with regard to motor phenotype., Methods: The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype., Results: Among the 689 PD patients (62.6 ± 8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p < 0.0001). FOG was related to functional dependency (OR = 3.470; 95%CI 1.411-8.530; p = 0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR = 7.163; 95%CI 1.206-42.564; p = 0.030)., Conclusions: Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients.
- Published
- 2020
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