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Background: Use of objective physical activity measures is rising. We investigated the representativeness of survey participants who wore an accelerometer. Methods: 4273 adults aged 16+ from a cross-sectional survey of a random, nationally representative general population sample in England in 2008 were categorized as 1) provided sufficient accelerometry data [4-7 valid days (10+ hrs/d), n = 1724], 2) less than that (n = 237), or 3) declined (n = 302). Multinomial logistic regression identified demographic, socioeconomic, health, lifestyle, and biological correlates of participants in these latter 2 groups, compared with those who provided sufficient accelerometry data (4+ valid days). Results: Those in the random subsample offered the accelerometer were older and more likely to be retired and to report having a longstanding limiting illness than the rest of the adult Health Survey for England participants. Compared with those providing sufficient accelerometery data, those wearing the accelerometer less were younger, less likely to be in paid employment, and more likely to be a current smoker. Those who declined to wear an accelerometer did not differ significantly from those who wore it for sufficient time. Conclusions: We found response bias in wearing the accelerometers for sufficient time, but refusers did not differ from those providing sufficient data. Differences should be acknowledged by data users. [ABSTRACT FROM AUTHOR]

Copyright of Ager: Journal of Depopulation & Rural Development Studies / Revista de Estudios sobre Despoblación y Desarrollo Rural is the property of Rolde de Estudios Aragoneses and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumour in adults, with a poor prognosis. Changing treatment paradigms suggest improved outcome, but whole nation data for England is scarce. The aim of this report is to examine the incidence of patients with glioblastoma in England, and to assess the influence of gender, age, geographical region and treatment on outcome. A search strategy encompassing all patients coded with GBM and treated from January 2007 to December 2011 was obtained from data linkage between the National Cancer Registration Service and Hospital Episode Statistics for England. There were 10,743 patients coded with GBM in this 5-year period (6451 male, 4292 female), giving an overall national age standardised incidence of 4.64/100,000/year. Incidence increases with age. Median survival overall was 6.1 months. One, 2 and 5-year survivals, were 28.4%, 11.5% and 3.4% respectively. Age stratified median survivals decreased significantly (p < 0.0001) with increasing age from 16.2 months for the 20–44 year age group, to 7.9 months for the 45–69 years, and 3.2 months for 70+ years. In the maximal treatment subgroup, patients aged up to 69 years had a median survival of 14.9 months. Patients over 60 years were less likely to receive maximal combination treatment but median survival was better with maximal treatment at all ages. The overall outcome for patients with GBM remains poor. However, aggressive treatment at every age group is associated with extended survival similar to that described in clinical trials. [ABSTRACT FROM AUTHOR]

Aims To assess the relationship between depression scores and diabetes, glucose and insulin in a cross-sectional population-based study. Methods One thousand, five hundred and seventy-nine men and 1418 women from the Hertfordshire Cohort Study were assessed for diabetes. Plasma glucose and insulin concentrations were measured at 0, 30 and 120 min during a standard 75-g oral glucose tolerance test. Depressive and anxiety symptoms were measured using the Hospital Anxiety and Depression Scale (HADS). Results Overall, 431 (14.6%) were diagnosed with diabetes [232 men (14.9%) and 199 women (14.3%)]. One hundred and eight (47%) men and 74 (37%) women had known diabetes. The remainder were previously undiagnosed. Fifty-nine (3.7%) men and 65 (4.6%) women had possible depression (HAD-D scores 8–10) and 17 (1.1%) men and 20 (1.4%) women had probable depression (HAD-D scores ≥ 11). Probable depression was associated with an adjusted odds ratio for diabetes of 3.89 [95% confidence interval (CI) 1.28–11.88] in men and 1.51 (95% CI 0.47–4.84) in women. In men without previously diagnosed diabetes, fasting insulin ( P = 0.035), 2-h glucose concentrations ( P = 0.028) and insulin resistance ( P = 0.032) were significantly associated with HAD-D scores. With the exception of 2-h glucose concentrations ( P = 0.034), the associations were not significant in women. Conclusions These data support the hypothesis that depression may increase the risk for diabetes. The relationship between depression score and metabolic variables extends across the whole population and is not confined to those with either diagnosed depression or diabetes. This relationship should lead clinicians to consider screening for diabetes in those with depression and vice versa. [ABSTRACT FROM AUTHOR]

Background: Acute aortic dissection is a preventable life-threatening condition. However, there have been no prospective population-based studies of incidence or outcome to inform an understanding of risk factors, strategies for prevention, or projections for future clinical service provision., Methods and Results: We prospectively determined incidence and outcomes of all acute aortic dissections in a population of 92 728 in Oxfordshire, United Kingdom, from 2002 to 2012. Among 155 patients with 174 acute aortic events, 54 patients had 59 thoracoabdominal aortic dissections (52 incident events: 6/100 000, 95% confidence interval, 4-7; 37 Stanford type A, 15 Stanford type B; 31 men, mean age=72.0 years). Among patients with type A incident events, 18 (48.6%) died before hospital assessment (61.1% women). The 30-day fatality rate was 47.4% for patients with type A dissections who survived to hospital admission and 13.3% for patients with type B dissections, although subsequent 5-year survival rates were high (85.7% for type A; 83.3% for type B). Even though 67.3% of patients were on antihypertensive drugs, 46.0% of all patients had at least 1 systolic BP ≥180 mm Hg in their primary care records over the preceding 5 years, and the proportion of blood pressures in the hypertensive range (>140/90 mm Hg) averaged 56.0%. Premorbid blood pressure was higher in patients with type A dissections that were immediately fatal than in those who survived to admission (mean/standard deviation pre-event systolic blood pressure=151.2/19.3 versus 137.9/17.9; P<0.001)., Conclusions: Uncontrolled hypertension remains the most significant treatable risk factor for acute aortic dissection. Prospective population-based ascertainment showed that hospital-based registries will underestimate not only incidence and case fatality, but also the association with premorbid hypertension.