1. Antifungal and molluscicidal saponins from Serjania salzmanniana.
- Author
-
Ekabo OA, Farnsworth NR, Henderson TO, Mao G, and Mukherjee R
- Subjects
- Animals, Antifungal Agents chemistry, Antifungal Agents isolation & purification, Biomphalaria, Candida albicans drug effects, Cryptococcus neoformans drug effects, Ethiopia, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molluscacides chemistry, Molluscacides isolation & purification, Saponins chemistry, Saponins isolation & purification, Spectrometry, Mass, Fast Atom Bombardment, Antifungal Agents toxicity, Molluscacides toxicity, Plants, Medicinal chemistry, Saponins toxicity
- Abstract
An investigation of Serjania salzmanniana for biologically active substances has led to the isolation of two novel saponins, salzmannianoside A (3-O-[[beta-D- glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl] gypsogenin) [3] and salzmannianoside B (3-O-[[beta-D-glucopyranosyl-(1-->4)]-[alpha-L- arabinopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)] -alpha-L-arabinopyranosyl] hederagenin) (4). Two known saponins, pulsatilla saponin D (3-O-[[beta-D- glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl] hederagenin) (1) and 3-O-[[beta-D-glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-a lpha-L- arabinopyranosyl] oleanolic acid (2) were also isolated from this plant. The structures of 3 and 4 were elucidated by FABMS and 2D NMR techniques. All these four saponins were mollusicidal, causing 70-100% mortality at 10 ppm against Biomphalaria alexandrina, a vector of Schistosoma mansoni in the Nile Valley. The saponins also showed antifungal activity against Cryptococcus neoformans and Candida albicans at minimal inhibitory concentrations of 8 and 16 micrograms/mL, respectively.
- Published
- 1996
- Full Text
- View/download PDF