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3 results on '"B Jung"'

1. Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium.

Author

Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, and Jung B

Subjects
Administration, Inhalation, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents pharmacokinetics, Critical Care, Dose-Response Relationship, Drug, Drug Resistance, Microbial, Drug Resistance, Multiple, Drug Therapy, Combination, Drug Utilization, Drugs, Investigational therapeutic use, Europe, Extracorporeal Membrane Oxygenation, Forecasting, Humans, Kidney Diseases chemically induced, Microbial Sensitivity Tests, Microbiota drug effects, Nebulizers and Vaporizers, Peripheral Nervous System Diseases chemically induced, Population Surveillance, beta-Lactams adverse effects, Anti-Bacterial Agents therapeutic use, Antimicrobial Stewardship, Intensive Care Units statistics & numerical data
Abstract

The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues about efficiency of combination therapy and the value of de-escalation, new perspectives of pharmacokinetics, drug toxicities including collateral damages-associated with antibiotics, the place of nebulisation of antibiotics, management of patients receiving extracorporeal therapies and the place of new antibiotics. In this paper, each of these issues is discussed with key messages presented after a brief review of evidence., (Copyright © 2019. Published by Elsevier Masson SAS.)

Published
2019
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2. Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12 status compared with pregnant women of European ethnicity.

Author

Schroder TH, Sinclair G, Mattman A, Jung B, Barr SI, Vallance HD, and Lamers Y

Subjects
Adult, Asia ethnology, Biomarkers blood, Canada epidemiology, Europe epidemiology, Female, Homocysteine blood, Humans, Pregnancy, Retrospective Studies, Young Adult, Asian People, Vitamin B 12 blood, Vitamin B 12 Deficiency epidemiology, White People
Abstract

Maternal vitamin B12 (B12) status has been inversely associated with adverse pregnancy outcomes and positively with fetal growth and infant development. South Asians, Canada's largest ethnic minority, are prone to B12 deficiency. Yet, data are lacking on B12 status in South Asian pregnant women in North America. We sought to determine B12 status, using multiple biomarkers, in 1st and 2nd trimester pregnant women of South Asian and, for comparison, European ethnicity living in Vancouver, Canada. In this retrospective cohort study, total B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and total homocysteine concentrations were quantified in two routinely collected (mean gestational week: 11·5 (range 8·3-13·9) and 16·5 (range 14·9-20·9)), banked serum samples of 748 healthy pregnant South Asian (n 371) and European (n 377) women. South Asian pregnant women had significantly lower B12 status than European pregnant women at both time points, as indicated by lower serum total B12 and holoTC concentrations, and higher MMA concentrations (all P≤0·001). The largest difference, which was substantial (Cohen's d≥0·5), was observed in mean serum total B12 concentrations (1st trimester: 189 (95 % CI 180, 199) v. 246 (95 % CI 236, 257) pmol/l; 2nd trimester: 176 (95 % CI 168, 185) v. 226 (95 % CI 216, 236) pmol/l). Further, South Asian ethnicity was a significant negative predictor of B12 status during pregnancy. South Asian women living in Vancouver have substantially lower B12 status during early pregnancy. Future research identifying predictors and health consequences of this observed difference is needed to allow for targeted interventions.

Published
2017
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3. [Management of patients after valvular heart surgery. Guidelines of the European Cardiologic Society].

Author

Butchart EG, Gohlke-Bärwolf K, Antunes MJ, Tornos P, Caterina RD, Cormier B, Prendergast B, Jung B, Bjornstad H, Report C, Hall RJ, and Vahanian A

Subjects
Europe, Female, Heart Valve Prosthesis Implantation methods, Humans, Male, Postoperative Care education, Postoperative Care rehabilitation, Postoperative Complications drug therapy, Postoperative Complications prevention & control, Treatment Outcome, Cardiac Surgical Procedures methods, Heart Valve Diseases surgery, Heart Valve Prosthesis Implantation standards, Mitral Valve surgery
Published
2006

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