1. Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus.
- Author
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Giardina, Emiliano, Hüffmeier, Ulrike, Ravindran, Jaya, Behrens, Frank, Lepre, Tiziana, McHugh, Neil J., Korendowych, Eleanor, Burkhardt, Harald, Novelli, Giuseppe, and Reis, André
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CONFIDENCE intervals ,EPIDEMIOLOGY ,GENES ,GENETIC polymorphisms ,MEDICAL cooperation ,RESEARCH ,PSORIATIC arthritis ,RESEARCH funding ,TUMOR necrosis factors ,DATA analysis ,CASE-control method ,DATA analysis software ,GENETICS ,DISEASE risk factors - Abstract
Objective The strongest susceptibility locus of psoriatic arthritis (PsA) is within the major histocompatibility complex (MHC) region (psoriasis susceptibility region 1, or PSORS1), and HLA-Cw*06:02 has been reported as the PSORS1 susceptibility allele. Non-HLA genes within the MHC region have also been implicated in PsA, but because of the strong linkage disequilibrium at chromosome 6p21, it is difficult to make a distinction between susceptibility alleles and linked markers. Recent studies have demonstrated that the association between PsA and the tumor necrosis factor (TNF) promoter polymorphism TNF*-857 is independent of PSORS1. The aim of this study was to replicate the independent association of TNF*-857 in patients with PsA. Methods A total of 909 patients with PsA and 1,315 healthy controls originating from the UK, Germany, and Italy were typed for TNF*-857 and for the estimated risk alleles of HLA-Cw*06:02. Results Overall, the results of genotyping in these 3 case-control cohorts replicated the finding that the frequency of carriers of TNF*-857 TT/CT who were negative for the PSORS1 risk allele was significantly higher among patients with PsA compared with control subjects (30% versus 21%; P = 9.17 × 10
−5 ). Conclusion The results of this collaborative study indicate that TNF*-857T is a susceptibility allele for PsA independent of the PSORS1 allele. [ABSTRACT FROM AUTHOR]- Published
- 2011
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