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1. Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study.

Author

Carlson, Christopher S., Matise, Tara C., North, Kari E., Haiman, Christopher A., Fesinmeyer, Megan D., Buyske, Steven, Schumacher, Fredrick R., Peters, Ulrike, Franceschini, Nora, Ritchie, Marylyn D., Duggan, David J., Spencer, Kylee L., Dumitrescu, Logan, Eaton, Charles B., Thomas, Fridtjof, Young, Alicia, Carty, Cara, Heiss, Gerardo, Le Marchand, Loic, and Crawford, Dana C.

Subjects
ETHNICITY, FAMILY history (Genealogy), GENETIC genealogy, POPULATION research, BODY mass index
Abstract

A multi-ethnic study demonstrates that the extrapolation of genetic disease risk models from European populations to other ethnicities is compromised more strongly by genetic structure than by environmental or global genetic background in differential genetic risk associations across ethnicities. [ABSTRACT FROM AUTHOR]

Published
2013
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