1. CAP-Inhibition, Molecular Diagnostics, and Total IgE in the Evaluation of Polistes and Vespula Double Sensitization.
- Author
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Quercia O, Cova V, Martini M, Cortellini G, Murzilli F, Bignardi D, Cilia M, Scarpa A, and Bilò MB
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Europe, Female, Humans, Immunization, Immunoglobulin E blood, Male, Middle Aged, Pathology, Molecular, Reproducibility of Results, Skin Tests, Venoms immunology, Wasps immunology, Young Adult, Allergens immunology, Anaphylaxis diagnosis, Cross Reactions, Desensitization, Immunologic methods, Hypersensitivity diagnosis, Insect Bites and Stings diagnosis
- Abstract
Cross-reactions between Polistes dominula and Vespula species are common in southern Europe. Currently, only CAP-inhibition demonstrates high accuracy in identifying genuine sensitizations, but this method is time-consuming and expensive, so a new approach is required. This study investigates skin tests, molecular diagnostics, total IgE (tIgE), and the Ves v 5/Pol d 5 (or vice versa) ratio. The ratio generated low-accuracy results and poor agreement with CAP-inhibition, and we did not find any agreement between CAP-inhibition test and double values of Ves v 5/Pol d 5. Nevertheless, a slight diagnostic improvement was obtained when Ves v 5/tIgE and Pol d 5/tIgE were measured., (© 2018 S. Karger AG, Basel.)
- Published
- 2018
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