1. Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study.
- Author
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Stewart-Knox BJ, Rae G, Simpson EE, McConville C, O'Connor J, Polito A, Andriollo-Sanchez M, Coudray C, and Strain JJ
- Subjects
- Aged, Aged, 80 and over, Double-Blind Method, Europe, Female, Humans, Male, Middle Aged, Trace Elements administration & dosage, Trace Elements blood, Trace Elements deficiency, Zinc administration & dosage, Zinc blood, Zinc deficiency, Affect drug effects, Dietary Supplements, Trace Elements pharmacology, Zinc pharmacology
- Abstract
Objective: Older people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans., Subjects: Healthy volunteers (n 387) aged 55-87 years were recruited., Setting: Volunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70-87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55-70 years., Design: Mood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention., Results: Mixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55-70 years or the ≥70 years age group., Conclusions: These results suggest that zinc does not benefit mood in healthy older people. more...
- Published
- 2011
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