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1. Detection of rifampicin resistance in Mycobacterium tuberculosis isolates from diverse countries by a commercial line probe assay as an initial indicator of multidrug resistance.

Author

Traore H, Fissette K, Bastian I, Devleeschouwer M, and Portaels F

Subjects
Africa epidemiology, Asia epidemiology, Europe epidemiology, Humans, Microbial Sensitivity Tests, Sensitivity and Specificity, South America epidemiology, Species Specificity, Tuberculosis, Multidrug-Resistant epidemiology, Antibiotics, Antitubercular pharmacology, Drug Resistance, Molecular Probe Techniques, Mycobacterium tuberculosis drug effects, Mycobacterium tuberculosis isolation & purification, Rifampin pharmacology, Tuberculosis, Multidrug-Resistant diagnosis, Tuberculosis, Multidrug-Resistant microbiology
Abstract

The line probe assay (LiPA), a rapid molecular method for detecting rifampicin resistance (RMPr) in Mycobacterium tuberculosis, correctly identified all 145 rifampicin-sensitive (RMPs) and 262 (98.5%) of 266 RMPr strains among 411 isolates collected from diverse countries. If used as a marker of multidrug-resistant tuberculosis (MDR-TB), detection of RMPr by LiPA would have detected 236 of the 240 MDR strains in this study but would have wrongly suggested the presence of MDR in 26 RMP-monoresistant isolates (sensitivity 98.3%, specificity 84.8%). Hence, the reliability of using LiPA (or any other rapid RMPr-detection method) as a surrogate marker of MDR-TB largely depends on the prevalence of RMP-monoresistance in the study population. This approach must therefore be validated in each local situation.

Published
2000

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