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This study found that individuals aged 50+ who have physically stressful jobs or low job reward, especially women, those with low/high levels of education or low levels of mental activity are at high-risk of CVD. The knowledge can help clinicians in counselling people seeking help for CVD prevention. Objective: The aim of the study is to investigate the influence of work-related psychological and physical stresses on risk of cardiovascular disease (CVD). Methods: A total of 5651 CVD-free participants older than 50 years from the Survey of Health, Ageing and Retirement in Europe were followed up for 13 years to detect incident CVD. Work-related stress was assessed using job strain and job reward questionnaire. Cox regression model was used to estimate the association. Results: High physical demands (hazard ratio [HR], 1.30) and low reward (HR, 1.19) compared with their counterparts, as well as active physical jobs (HR, 1.41) and high physical strain (HR, 1.45) in comparison with low physical strain were associated with higher risk of incident CVD after adjusting for confounders. However, combining physically stressful jobs with low reward did not further increase the CVD risk. Conclusions: Avoiding physically stressful jobs or providing appropriate reward may reduce the occurrence of CVD. [ABSTRACT FROM AUTHOR]

• Participants with chronic diseases were at higher risk of new onset depression than those without any chronic disease. • The risk of new onset depression increased with increasing number of chronic diseases. • Heart attack, stroke, diabetes, chronic lung disease and arthritis were significantly related to increased risks of new onset depression among both younger (aged 50–64) and older (aged >= 65) participants. • Cancer was significantly related to increased risks of new onset depression among younger individuals, while peptic ulcer, parkinson's disease and cataracts were significantly associated with an increased risk of new onset depression among older participants. The causal association between chronic diseases and depression remains unclear. This study aimed to explore the effects of types and number of chronic diseases on the risk of depression using data from the Survey of Health, Ageing and Retirement in Europe (SHARE). A self-admitted questionnaire was used to obtain data on 14 predefined chronic diseases and the European-Depression Scale (EURO-D) was used to assess depression. Among the 16,080 baseline depression-free participants aged 50+, 31.29% (5032) developed depression over 13 years. Multivariate Cox regression models showed that individuals with any chronic diseases were at higher risk of new onset depression compared to disease-free participants. The risk of new onset depression increased with an increasing number of diseases among both younger (50–64) and older (65+) adults. Individuals with heart attack, stroke, diabetes, chronic lung disease, and arthritis were at increased risk of depression across age groups. However, some age-specific associations were observed, with cancer increasing depression risk among younger- and peptic ulcer, Parkinson's disease and cataracts increasing depression risk among older adults. These findings highlight the importance of managing chronic diseases, especially among those with more than two diseases, to prevent the development of depression among middle-aged and older adults. [ABSTRACT FROM AUTHOR]