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Open Science is a paradigm in which scientific data, procedures, tools and results are shared transparently and reused by society. The European Open Science Cloud (EOSC) initiative is an effort in Europe to provide an open, trusted, virtual and federated computing environment to execute scientific applications and store, share and reuse research data across borders and scientific disciplines. Additionally, scientific services are becoming increasingly data-intensive, not only in terms of computationally intensive tasks but also in terms of storage resources. To meet those resource demands, computing paradigms such as High-Performance Computing (HPC) and Cloud Computing are applied to e-science applications. However, adapting applications and services to these paradigms is a challenging task, commonly requiring a deep knowledge of the underlying technologies, which often constitutes a general barrier to its uptake by scientists. In this context, EOSC-Synergy, a collaborative project involving more than 20 institutions from eight European countries pooling their knowledge and experience to enhance EOSC's capabilities and capacities, aims to bring EOSC closer to the scientific communities. This article provides a summary analysis of the adaptations made in the ten thematic services of EOSC-Synergy to embrace this paradigm. These services are grouped into four categories: Earth Observation, Environment, Biomedicine, and Astrophysics. The analysis will lead to the identification of commonalities, best practices and common requirements, regardless of the thematic area of the service. Experience gained from the thematic services can be transferred to new services for the adoption of the EOSC ecosystem framework. The article made several recommendations for the integration of thematic services in the EOSC ecosystem regarding Authentication and Authorization (federated regional or thematic solutions based on EduGAIN mainly), FAIR data and metadata preservation solutions (both at cataloguing and data preservation—such as EUDAT's B2SHARE), cloud platform-agnostic resource management services (such as Infrastructure Manager) and workload management solutions. [Display omitted] • EOSC aims at building an environment to share research data, sw & services. • Adapting thematic services on Federated Infrastructures aligns with EOSC objectives. • Key factors for the success of EOSC are performance and acknowledgement by the users. • Analysis of EOSC service adoption provides feedback on usability and adaptability. • 10 services offer experiences in community-oriented data services for Open Science [ABSTRACT FROM AUTHOR]

Aims: To evaluate the late outcomes of adults (above 35 years) with a Fontan-type circulation, for whom current data on morbidity and mortality are lacking., Methods and Results: Data were collected retrospectively on consecutive patients with Fontan circulation above the age of 35 years followed in three European specialist centres. Overall, 115 Fontan patients were included [median age 35 (range 35-48) years, 47.8% female]. The most common underlying congenital heart disease diagnosis was tricuspid atresia (n = 58, 50.4%), and the age at first Fontan completion was 9.1 (interquartile range 5.0-15.8) years. Almost two-thirds (61.7%) of patients had undergone an atriopulmonary Fontan, and 23.5% had received a total cavopulmonary connection. One-third required repeat surgery or intervention. Most patients (55.9%) were in New York Heart Association functional class II or class I (30.6%), 76 (66.1%) patients had experienced at least one arrhythmia, and eight (7.0%) protein-losing enteropathy. At a median follow-up of 5.0 (2.4-10.3) years, 15 (13.0%) patients were referred for transplantation assessment and 19 (16.5%) patients died, mainly from heart failure (84.2%). Univariable predictors of death or transplantation included lower serum albumin level [hazard ratio (HR) 1.09 per g/L decrease, 95% confidence interval (CI): 1.04-1.15, P = 0.0009], prior heart failure admission (HR 4.28, 95% CI:1.75-10.44, P = 0.001), prior atrial tachycardia or flutter (HR 3.02, 95% CI: 1.23-7.38, P = 0.02), and baseline pulmonary vasodilator therapy (HR 8.59, 95% CI:1.05-70.13, P = 0.04). Lower serum albumin and prior atrial tachycardia or flutter remained significant on bivariable analysis., Conclusion: Our study highlights the significant morbidity and mortality in older adults with a Fontan-type circulation, emphasizing the need for lifelong specialist surveillance with frequent risk stratification, close monitoring, and early consideration for transplantation assessment., Competing Interests: Conflict of interest: A.C. has received educational grants, personal fees, and non-financial support from Janssen-Cilag Limited. K.D. has received non-financial support from Janssen-Cilag Limited and has been a consultant to and received grants and personal fees from Janssen-Cilag Limited, Pfizer, GlaxoSmithKline, and Bayer/MSD. All the remaining authors have no relationships with industry to declare., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)