1. Therapy for acute myeloid leukemia and acute lymphoblastic leukemia in adults.
- Author
-
Geller RB and Larson RA
- Subjects
- Adult, Age Factors, Bone Marrow Transplantation, Child, Combined Modality Therapy, Europe epidemiology, Humans, Leukemia classification, Leukemia, Myeloid, Acute mortality, Leukemia, Myeloid, Acute surgery, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma mortality, Precursor Cell Lymphoblastic Leukemia-Lymphoma surgery, Prognosis, Remission Induction, Survival Rate, United States epidemiology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Leukemia, Myeloid, Acute drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
- Abstract
Using intensive induction chemotherapy, primarily with combinations of an anthracycline and cytarabine, complete remission rates of greater than 70% are now achieved in patients with acute myeloid leukemia under the age of 60 years. The treatment of elderly patients with acute myeloid leukemia is difficult and remains controversial. The prognosis for both adults and children with acute lymphoblastic leukemia has improved as more extensive chemotherapy regimens have been used. Recently, a group of leukemias have been identified that have features of both acute lymphoblastic leukemia and acute myeloid leukemia, and these are referred to as biphenotypic or hybrid leukemias. These hybrid leukemias represent an important subgroup, which appears to have a worse outcome regardless of the therapy administered.
- Published
- 1991
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