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The EU Nature Restoration Law represents an important opportunity for freshwater habitat restoration and, consequently, freshwater biodiversity protection. However, a number of challenges must be anticipated in its implementation, which may compromise its success. Some aspects, particularly those relating to freshwater ecosystems, require more clarification. We use riverine ecosystems to illustrate existing ambiguities in the proposed legislation and the potential consequences of leaving these aspects open to interpretation during the implementation process. We also discuss potential solutions to these problems which could help ensure that the law's objectives are met. We argue that river network structure and connectivity dimensions, which result into river meta‐ecosystems, must be explicitly considered. For that purpose, we ask for clear definitions of the critical terms "free‐flowing rivers," "barriers," and "reference areas." In addition, we recommend developing methods for integrated assessment of connectivity across river networks. As a key property of river ecosystems, this must be used to prioritize actions to increase the length and number of free‐flowing rivers. Adequate restoration planning at larger spatial scales will benefit from a meta‐ecosystem perspective and accurate representation of aquatic‐terrestrial linkages, which will significantly improve the efficacy of restoration efforts. Furthermore, stakeholder and citizen engagement offer important opportunities at local, national, and European scales, and should be fostered to ensure inclusive decision‐making. The conservation challenges outlined here are particularly important for rivers, but they also have implications for other ecosystems. These considerations are useful for policymakers, conservationists, and other stakeholders involved in the Nature Restoration Law and related policy initiatives. This article is categorized under:Water and Life > Stresses and Pressures on EcosystemsWater and Life > Conservation, Management, and AwarenessHuman Water > Water Governance [ABSTRACT FROM AUTHOR]

Purpose: Group B streptococcus (GBS) remains a leading cause of invasive disease, mainly sepsis and meningitis, in infants < 3 months of age and of mortality among neonates. This study, a major component of the European DEVANI project (Design of a Vaccine Against Neonatal Infections) describes clinical and important microbiological characteristics of neonatal GBS diseases. It quantifies the rate of antenatal screening and intrapartum antibiotic prophylaxis among cases and identifies risk factors associated with an adverse outcome. Methods: Clinical and microbiological data from 153 invasive neonatal cases (82 early-onset [EOD], 71 late-onset disease [LOD] cases) were collected in eight European countries from mid-2008 to end-2010. Results: Respiratory distress was the most frequent clinical sign at onset of EOD, while meningitis is found in > 30% of LOD. The study revealed that 59% of mothers of EOD cases had not received antenatal screening, whilst GBS was detected in 48.5% of screened cases. Meningitis was associated with an adverse outcome in LOD cases, while prematurity and the presence of cardiocirculatory symptoms were associated with an adverse outcome in EOD cases. Capsular-polysaccharide type III was the most frequent in both EOD and LOD cases with regional differences in the clonal complex distribution. Conclusions: Standardizing recommendations related to neonatal GBS disease and increasing compliance might improve clinical care and the prevention of GBS EOD. But even full adherence to antenatal screening would miss a relevant number of EOD cases, thus, the most promising prophylactic approach against GBS EOD and LOD would be a vaccine for maternal immunization. [ABSTRACT FROM AUTHOR]

Industrial processes generate various quantities of waste that can be contaminated with radionuclides of natural origin (naturally occurring radioactive material ('NORM waste')). The efficient management of this waste is essential for any industries affected by NORM waste generation. To obtain an overview of current practices and approaches in Europe, the IRPA Task Group on NORM conducted a survey among task group members and other experts from European countries. The results revealed significant differences in methods and approaches in the European countries. In many countries, landfills are used to dispose of small- and medium-sized quantities of NORM waste with limited activity concentration. But our survey indicated that despite a uniform reference basis for national legislation in Europe, there are different framework conditions for the disposal of NORM waste in practice. In some countries, the disposal is hampered because the interface between the radiation protection system and the waste regime is not yet clearly regulated. Particular practical problems include the lack of acceptance of waste because of the 'radioactivity' stigma and only vague specifications by the legislators on acceptance obligations of the waste management sector. [ABSTRACT FROM AUTHOR]

Can older managers overcome stereotypes relating age to low competence? We integrate the literature on age and cognitive ability with research on innovation to explore whether—and if so, when—employees' age harms performance and promotability appraisals made by their supervisors. Multisource, time‐lag data from 305 project managers indicate that the negative stereotypes can be explained through decreased innovative behavior. However, older employees are not always seen as poorer performers with less potential to be promoted due to their reduced innovative behavior. Rather, interdepartmental collaboration moderates these effects. Specifically, older employees with low interdepartmental collaboration are less innovative and receive worse performance and promotability appraisals than younger employees, but the "age handicap" vanishes when older employees collaborate with members of other departments. Organizations should foster formal or informal collaboration among units to prevent negative consequences of an aging workforce. [ABSTRACT FROM AUTHOR]

There has been an increase in reported TBE cases in Europe since 2015, reaching a peak in some countries in 2020, highlighting the need for better management of TBE risk in Europe. TBE surveillance is currently limited, in part, due to varying diagnostic guidelines, access to testing, and awareness of TBE. Consequently, TBE prevalence is underestimated and vaccination recommendations inadequate. TBE vaccine uptake is unsatisfactory in many TBE-endemic European countries. This review summarizes the findings of a scientific workshop of experts to improve TBE surveillance and vaccine uptake in Europe. Strategies to improve TBE surveillance and vaccine uptake should focus on: aligning diagnostic criteria and testing across Europe; expanding current vaccine recommendations and reducing their complexity; and increasing public education of the potential risks posed by TBEV infection. [ABSTRACT FROM AUTHOR]

Porcine Parvovirus Type 1 (PPV1) contributes to important losses in the swine industry worldwide. During a PPV1 infection, embryos and fetuses are targeted, resulting in stillbirth, mummification, embryonic death, and infertility (SMEDI syndrome). Even though vaccination is common in gilts and sows, strains mainly belonging to the 27a-like group have been spreading in Europe since early 2000s, resulting in SMEDI problems and requiring in-depth studies into the molecular epidemiology and vaccination efficacy of commercial vaccines. Here, we show that PPV1 has evolved since 1855 [1737, 1933] at a rate of 4.71 × 10−5 nucleotide substitutions per site per year. Extensive sequencing allowed evaluating and reassessing the current PPV1 VP1-based classifications, providing evidence for the existence of four relevant phylogenetic groups. While most European strains belong to the PPV1a (G1) or PPV1b (G2 or 27a-like) group, most Asian and American G2 strains and some European strains were divided into virulent PPV1c (e.g. NADL-8) and attenuated PPV1d (e.g. NADL-2) groups. The increase in the swine population, vaccination degree, and health management (vaccination and biosafety) influenced the spread of PPV1. The reactivity of anti-PPV1 antibodies from sows vaccinated with Porcilis© Parvo, Eryseng© Parvo, or ReproCyc© ParvoFLEX against different PPV1 field strains was the highest upon vaccination with ReproCyc© ParvoFLEX, followed by Eryseng© Parvo, and Porcilis© Parvo. Our findings contribute to the evaluation of the immunogenicity of existing vaccines and support the development of new vaccine candidates. Finally, the potential roles of cluster-specific hallmark amino acids in elevated pathogenicity and viral entry are discussed. [ABSTRACT FROM AUTHOR]

Tobacco consumption and its consequences on health affect men more than women. Among young people however there is evidence of a trend of more girls than youths taking up smoking.In animals (rats and mice), males have higher densities of nicotine repectors, among humans, women seem to be less discriminating in their nicotine intake than men, and regulate their nicotine concentrations less precisely. Women smoke more than men in response to negative effects and weight concerns, and the association between smoking and depression seem to be stronger for women. Quitting seems to be more difficult for women and often they compensate by making more frequent attempts.The age and gender distribution of the Swedish and Austrian population are very similar. Sweden has the lowest male smoking prevalence in Europe (16% daily) and Austria has a high smoking male prevalence (32%). Lung cancer mortality rates attributed to smoking are lower in Swedish men than in Austrian men. The difference in prevalence between Swedish women (22%) and Austrian women (26%) is not so great and the similar rates of mortality from lung cancer reflect this. [Copyright &y& Elsevier]

Based on an EU-wide empirical survey, this paper proposes the alternative concept of collective and politically motivated renewable energy (CPE) projects that includes different forms of enterprises such as co-operatives and participatory public utilities. In doing so, we intend to take a clearer stance on both organisational and ownership features and the political motivation of these projects. The aim is to overcome the vagueness of the term 'community energy' and to widen the perspective beyond the British context. Mapping CPE projects across different European countries we have identified three development trends and provide a project case study for each trend: the further dissemination of local CPE projects, the formation of regional projects, and the occurrence of urban CPE projects. Countries covered are the United Kingdom, Spain and Germany. We also reflect our findings for the concept of community energy and invite researchers to expand upon our research. [ABSTRACT FROM AUTHOR]

Background: The relationship between phoneme awareness, rapid automatized naming (RAN), verbal short-term/working memory (ST/WM) and diagnostic category is investigated in control and dyslexic children, and the extent to which this depends on orthographic complexity. Methods: General cognitive, phonological and literacy skills were tested in 1,138 control and 1,114 dyslexic children speaking six different languages spanning a large range of orthographic complexity (Finnish, Hungarian, German, Dutch, French, English). Results: Phoneme deletion and RAN were strong concurrent predictors of developmental dyslexia, while verbal ST/WM and general verbal abilities played a comparatively minor role. In logistic regression models, more participants were classified correctly when orthography was more complex. The impact of phoneme deletion and RAN-digits was stronger in complex than in less complex orthographies. Conclusions: Findings are largely consistent with the literature on predictors of dyslexia and literacy skills, while uniquely demonstrating how orthographic complexity exacerbates some symptoms of dyslexia. [ABSTRACT FROM AUTHOR]

The purpose of this paper was to present the current knowledge on the prevention of group B streptococcus (GBS) neonatal infections and the status of prevention policies in European countries and to present the DEVANI pan-European program, launched in 2008. The aim of this program was to assess the GBS neonatal infection burden in Europe, to design a new vaccine to immunize neonates against GBS infections, to improve the laboratory performance for the diagnosis of GBS colonization and infection, and to improve the methods for the typing of GBS strains. The current guidelines for GBS prevention in different countries were ascertained and a picture of the burden before and after the instauration of prevention policies has been drawn. After the issue of the Centers for Disease Control and Prevention (CDC) guidelines, many European countries have adopted universal screening for the GBS colonization of pregnant women and intrapartum prophylaxis to colonized mothers. Nevertheless, some European countries continue advocating the risk factor approach to GBS prevention. Most European countries have implemented policies to prevent GBS neonatal infections and the burden of the disease has decreased during the last several years. Nevertheless, further steps are necessary in order to develop new strategies of prevention, to improve microbiological techniques to detect GBS colonization and infection, and to coordinate the prevention policies in the EU. [ABSTRACT FROM AUTHOR]

In many densely populated areas, riverine floodplains have been strongly impacted and degraded by river channelization and flood protection dikes. Floodplains act as buffers for flood water and as filters for nutrients and pollutants carried with river water and sediment from upstream source areas. Based on results of the EU-funded “AquaTerra” project (2004–2009), we analyze changes in the dynamics of European river–floodplain systems over different temporal scales and assess their effects on contaminant behaviour and ecosystem functioning. We find that human-induced changes in the hydrologic regime of rivers have direct and severe consequences on nutrient cycling and contaminant retention in adjacent floodplains. We point out the complex interactions of contaminants with nutrient availability and other physico-chemical characteristics (pH, organic matter) in determining ecotoxicity and habitat quality, and draw conclusions for improved floodplain management. [Copyright &y& Elsevier]

The optimal design of immigration policy is a topical issue, both in the policy debate and the economic literature. In this paper, we present empirical evidence from a firm level dataset collected in 2000 on the demand for high-skilled workers, including foreign workers, in Europe and its determinants. Our major findings are that the fraction of high-skilled workers recruited from the international labour market is very small, and that foreign and domestic workers are very similar in terms of their formal education (measured by specialization subject) and their job characteristics. We suggest an efficiency wage model to explain why firms recruit foreign workers in small numbers, and why they are willing to pay immigrants the same wage as local workers, whilst at the same time also paying for their moving costs, despite the similar human capital profile of immigrants to domestic workers. [ABSTRACT FROM AUTHOR]

Background: Tobacco is addictive and cigarette smoking causes significant morbidity among smokers due to the harmful side effects of tar and other constituents. Many diseases caused by tobacco smoking result in death, of which half are premature. When smokers stop smoking, even in middle age, there is a substantial improvement in life expectancy. Stopping smoking is not always so easy: the addictive nature of nicotine makes it a lot easier to start smoking than to stop permanently. Currently, 40% of men and 30% of women in the European Union smoke, although there is little information about how many of these want to stop smoking and what their attitudes to stopping are. Methods: Representative samples of smokers were interviewed in the fifteen Member States of the European Union as well as Poland and Russia, employing individual, face-to-face interviews. The national characteristics in key variables, such as age, gender, socio-economic status and urban-rural status, were included in the study design in all countries. The sample comprised a representative sample of smokers, aged 18 or more, in each country. A combined total of 10,295 smokers were interviewed. Results: Overall, the majority of smokers want to stop smoking. This percentage varies greatly between countries, with 84% in Sweden stating that they wished to stop compared with less than 40% in Austria, Germany and Italy. Smokers want to be told by their doctor that they should stop smoking. However, only 34% of smokers have been told by their doctor to stop smoking and only 11.6% have been counselled by their doctor about the possible assistance available to help them stop successfully. The similarity of the findings in men and women is notable. Conclusion: For the first time, data are available from representative samples of European Smokers to give a picture of smokers and some of their attitudes and patterns of behaviour. These findings reinforce the conclusion that there should be a wide range of activities utilised to achieve Tobacco Control. Everything that can be done to prevent children and adolescents starting to smoke must be identified and implemented. Doctors should routinely advise their patients who smoke that they should stop smoking and inform them of what help is available to do so. The proportion of adult smokers who wish to stop needs to be further increased and all the help necessary to improve the probability that an attempt to stop smoking is successful should be made available to those who wish to stop smoking. Smokers should be considered as patients with an addictive disease. [ABSTRACT FROM AUTHOR]

Floodplains provide an extraordinary quantity and quality of ecosystem services (ES) but are among the most threatened ecosystems worldwide. The uses and transformations of floodplains differ widely within and between regions. In recent decades, the diverse pressures and requirements for flood protection, drinking water resource protection, biodiversity, and adaptation to climate change have shown that multi-functional floodplain management is necessary. Such an integrative approach has been hampered by the various interests of different sectors of society, as represented by multiple stakeholders and legal principles. We present an innovative framework for integrated floodplain management building up on ES multi-functionality and stakeholder involvement, forming a scientifically based decision-support to prioritize adaptive management measures responding at the basin and local scales. To demonstrate its potential and limitations, we applied this cross-scaled approach in the world's most international and culturally diverse basin, the Danube River Basin in Europe. We conducted large-scale evaluations of anthropogenic pressures and ES capacities on the one hand and participatory modelling of the local socio-ecohydrological systems on the other hand. Based on our assessments of 14 ES and 8 pressures, we recommend conservation measures along the lower and middle Danube, restoration measures along the upper-middle Danube and Sava, and mitigation measures in wide parts of the Yantra, Tisza and upper Danube rivers. In three case study areas across the basin, stakeholder perceptions were generally in line with the large-scale evaluations on ES and pressures. The positive outcomes of jointly modelled local measures and large-scale synergistic ES relationships suggest that multi-functionality can be enhanced across scales. Trade-offs were mainly present with terrestrial provisioning ES at the basin scale and locally with recreational activities. Utilizing the commonalities between top-down prioritizations and bottom-up participatory approaches and learning from their discrepancies could make ecosystem-based management more effective and inclusive. [Display omitted] • A first cross-scaled DPSIR assessment of floodplains in the Danube River Basin. • We provide a spatial prioritization scheme based on floodplain multi-functionality. • Synergies dominate across scales, supporting ecosystem-based management. • A few discrepancies between scales offer opportunities for mutual learning. [ABSTRACT FROM AUTHOR]

Autosomal dominant medullary cystic kidney disease type 2 (MCKD2) is a tubulo-in terstitial nephropathy that causes renal salt wasting, hyperuricemia, gout, and end-stage renal failure in the fifth decade of life. This disorder was described to have an age of onset between the age of 20-30 years or even later. Mutations in the Uromodulin (UMOD) gene were published in patients with familial juvenile hyperuricemic nephropathy (FJHN) and MCKD2. Clinical data and blood samples of 16 affected individuals from 11 different kindreds were collected. Mutational analysis of the UMOD gene was performed by exon polymerase chain reaction (PCR) and direct sequencing. We found the heterozygous C744G (Cys248Trp) mutation, which was originally published by our group, in an additional four kindreds from Europe and Turkey. Age of onset ranged from 3 years to 39 years. The phenotype showed a variety of symptoms such as urinary concentration defect, vesicoureteral reflux, urinary tract infections, hyperuricemia, hypertension, proteinuria, and renal hypoplasia. Haplotype analysis showed cosegragation with the phenotype in all eight affected individuals indicating that the C744G mutation may be due to a founder effect. Moreover, we describe a novel T229G (Cys77Gly) mutation in two affecteds of one kindred. Three of the affected individuals were younger than 10 years at the onset of MCKD2/FJHN. Symptoms include recurrent urinary tract infections compatible with the published phenotype of the Umod knockout mouse model. This emphasizes that MCKD2 is not just a disease of the young adult but is also relevant for children.