1. OLGA gastritis staging in young adults and country-specific gastric cancer risk.
- Author
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Rugge M, Kim JG, Mahachai V, Miehlke S, Pennelli G, Russo VM, Perng CL, Chang FY, Tandon RK, Singal DK, Sung JJ, Valenzuela JE, Realdi G, Dore MP, and Graham DY
- Subjects
- Adolescent, Adult, Americas epidemiology, Asia epidemiology, Atrophy, Biopsy, Chronic Disease, Europe epidemiology, Gastritis epidemiology, Gastritis microbiology, Helicobacter Infections epidemiology, Helicobacter Infections microbiology, Helicobacter pylori isolation & purification, Humans, International Cooperation, Precancerous Conditions epidemiology, Precancerous Conditions microbiology, Risk Factors, Single-Blind Method, Stomach Neoplasms microbiology, Gastritis diagnosis, Helicobacter Infections diagnosis, Precancerous Conditions diagnosis, Severity of Illness Index, Stomach Neoplasms diagnosis
- Abstract
Geographical differences have been shown in the clinical outcomes of Helicobacter pylori-associated gastritis phenotypes and in gastric cancer risk. This study tested whether the Operative Link on Gastritis Assessment (OLGA) staging correlated with gastric cancer risk in populations from 3 continents. Mapped gastric biopsies were obtained from 316 dyspeptic adults aged less than 41 years from 8 geographic areas that differed in gastric cancer risk. Gastric atrophy was assessed according to internationally validated criteria. Gastritis stage was established according to the OLGA staging system. The most prevalent gastritis stages were 0 to II, which included all subjects entered from Chile, Germany, India, Italy, and Thailand. Gastritis Stages III and IV were limited to the Chinese and Korean populations. Indians had a high prevalence of H pylori infection without high-stage gastritis. In populations at different cancer risk, the gastritis OLGA stage mirrored the gastric cancer incidence. Gastritis staging identifies a subgroup of higher-risk patients.
- Published
- 2008
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