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Aim: To ascertain the clinical profile and management of edoxaban in clinical practice. Materials & methods: Prospective, noninterventional postauthorization study of nonselected patients with atrial fibrillation treated with edoxaban from 12 European countries. Patients' baseline characteristics are presented. Results: A total of 13,638 patients (73.6 ± 9.5 years; 76.6/23.4% edoxaban 60/30 mg; CHA2DS2-VASc 3.1; 838 [6.1%] from Spain) were included. In Spain, the percentage of very elderly and fragile patients was greater and the risk of thromboembolism (CHA2DS2-VASc ≥2, 98.0 vs 87.3%; p < 0.001) and bleeding (HAS-BLED, 3.2 vs 2.7; p < 0.001) was greater in patients treated with edoxaban 30 mg. The proportion of patients taking edoxaban 30 mg was similar than in ENGAGE AF-TIMI 48. Conclusion: In Spain, patients treated with edoxaban were older and fragile. [ABSTRACT FROM AUTHOR]

Political parties and candidates have not been immune to the changes that the Internet and social media have introduced in electoral campaigns. Yet, as the use of digital media by political elites is becoming a norm in the United States, in Europe, the decision to develop an online presence depends on the cross-national differences regarding candidates’ constraints and incentives. European Parliament elections present an exceptional comparative opportunity to measure this potential diversity. Using an original database on the online presence of more than 5000 candidates competing under the label of incumbent parties in 2014, we demonstrate that there are two relevant groups of nonadopters, and that candidates’ online campaign intensity varies significantly depending on incumbency and the ballot structure in their countries. [ABSTRACT FROM AUTHOR]

Daily fund data and Sharpe's (1992) style methodology are used to evaluate the performance and forecasting skill of European mutual fund managers. Specifically, this study addresses the following question: do European fund managers add value to their investors by actively managing their portfolio's country exposure? To look into this issue, a methodology based on attribution returns is employed. An attribution return is defined as the difference between a fund's actual month t return and the return that would have been generated by the fund month t - 1 portfolio's country exposure. European fund managers, as a group, add value to their investors by managing their portfolio's country exposure as evidenced by a positive mean attribution return. Also, during the same sample period but based on the more traditional performance measure alpha, these funds outperform a regional benchmark and both measures are found to be positively correlated. [ABSTRACT FROM AUTHOR]

Introduction and Objectives: We present the data corresponding to implantable cardioverter-defibrillator (ICD) implants in Spain in 2019., Methods: The data were drawn from implant centers voluntarily completing a data collection sheet., Results: In 2019, 7003 implant sheets were received compared with the 7389 reported by Eucomed (European Confederation of Medical Suppliers Associations), indicating that data were collected from 94.8% of the devices implanted in Spain. Completion of the implant sheet ranged from 99.7% in the field "name of the implanting hospital" to 17.8% in the variable "reference hospital". In 2019, 172 hospitals performed ICD implants and participated in the registry, a figure similar to that of 2018 (173). The total rate of registered implants was 149/million inhabitants; the rate reported by Eucomed was 157. Although this value represents the highest in the historical series, it is still much lower than the average rate of ICD implants in Europe (303)., Conclusions: The Spanish Implantable Cardioverter-Defibrillator Registry for 2019 reflects a growth in the number of ICD implants and is the year with the highest number of ICD implants in Spain. However, similar to previous years, the total number of implants in Spain is still much lower than the European Union average, with substantial differences between Spanish autonomous communities., (Copyright © 2020 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.)