Search

It has been known for many years that the excessive consumption of sugar (sucrose) has harmful effects on human health. This fact led to a reduction in sugar consumption and the appearance of artificial sweeteners in the 1800s. The first low-cost and low-calorie sugar alternative was saccharin. Since this sweetener gained great popularity, other artificial sweeteners soon followed, including aspartame, acesulfame-K and cyclamates as the most common ones. As the result of a sharp rise in the obesity pandemic in all populations and ethnic groups, a demand for sweeteners with a minimum caloric value has increased dramatically in the last decade as consumers care more about their health. Due to the different regulation of permitted artificial sweeteners in United States (US) and Europe (EU), there are some controversies and suspicions about the relationship between certain sweeteners and a potential health risk. Despite doubts about the safety of artificial sweeteners, many studies have shown the absence of dangers associated with their use (if used in the acceptable daily intake, ADI). Therefore, artificial sweeteners today are considered as safe for consumption by many competent institutions and organisations. Nowadays, artificial sweeteners are fundamental in the food industry and present in many foodstuffs. [ABSTRACT FROM AUTHOR]

The possible application of a hot-melt ram extrusion printing to the preparation of diclofenac orodispersible films (ODF) made of maltodextrin was studied focusing the attention on the effects of taste-masking agents (i.e. namely mint, licorice-mint, and sucralose) and an opacifier (titanium dioxide [TiO2]). This is a proof-of-concept of the feasibility to print ODF loaded with a thermosensitive drug substance by hot-melt technologies. Diclofenac sodium (DNa) ODF made of maltodextrin (dextrose equivalent (DE) = 6) plasticized with glycerol were prepared by hot-melt extrusion printing. ODF were characterized for disintegration time, drug content, and solid state, in vitro dissolution in deionized water and simulated salivary fluid at pH 5.7, tensile, and adhesive properties. Moreover, the stability of ODF was assessed in accelerated conditions over six months. After the preparation, no variation in drug solid state was evident and the formation of impurity A of DNa was detected, even if it remained below the Pharmacopoeia (Ph. Eur.) limits (< 0.2%). Only the addition of DNa significantly improved the ODF tensile properties: the tensile strength increased from 0.17 ± 0.03 MPa (placebo ODF) to 2.21 ± 0.54 MPa (p ≤ 0.03). All ODF disintegrated in about 1 min, and the t80% was lower than 3 min. TiO2 reduced the static and dynamic peel forces (p ≤ 0.006) favoring the ODF detachment from the primary packaging material. During the accelerated stability study, ODF were easy to handle without fracture; the drug content, impurity A, and dissolution profiles remained superimposable. Hot-melt printing can be suitable to prepare palatable ODF loaded with bitter thermosensitive drugs. [ABSTRACT FROM AUTHOR]

Contaminants of emerging concern (CEC) are a focus in marine protection. Several CECs are released with wastewater effluents to coastal environments and their offshore occurrence has been recently documented. Routine monitoring is key for implementing marine protection acts, however infrastructural, financial, and technical limitations hinder this task along broad spatial transects. Here we show the efficacy of a new infrastructure enabling unmanned sampling of surface water from ships of opportunity in providing reliable and cost-effective routine monitoring of CECs along a Europe-Arctic transect. The distribution and long-range transport of several pharmaceuticals and personal care products, artificial food additives, and stimulants were assessed. Validation of operations through strict procedural and analytical quality criteria is presented. A framework to estimate a compound-specific spatial range (SR) index of marine long-range transport based on monitoring results and information on source spatial distribution, is introduced. Estimated SR values ranged 50–350 km depending on compound, yielding a ranking of long-range transport potential which reflected expectations based on degradation half-lives. SR values were used to calculate prior maps of detection probability that can be used to plan future routine monitoring in the region. [Display omitted] • Marine CECs analyzed through unmanned sampling from ships of opportunity. • Several CECs were successfully detected along a Europe-Arctic transect. • A Marine long-range transport index empirically determined for tracer compounds. • Prior maps of detection probability presented to inform future monitoring. [ABSTRACT FROM AUTHOR]

Abstract: An analytical method was developed for the analysis of sucralose, a persistent chlorinated calorie-free sugar substitute, in surface waters. The method is based on solid-phase extraction (SPE) of 400mL water using Oasis HLB (Waters) adsorber material, followed by negative electrospray ionization (ESI) triple quadrupole LC–MS–MS detection. Quantification was performed by external calibration, as well as by isotope dilution with deuterated sucralose d6 internal standard. Extraction with Oasis HLB, a polymeric adsorbent suited for polar compounds, was much more efficient at neutral pH than at pH 3; a recovery of 62±9% (n =6; determined at 1μg/L) could be achieved. Strong ion suppression caused by matrix substances was observed for sucralose in the SPE extracts. The analysis of 120 river surface water samples from 27 European countries showed that sucralose, which is in use in Europe since beginning 2005, can be found in the aquatic environment, at concentrations up to 1μg/L. Sucralose was predominately found in samples from the UK, Belgium, the Netherlands, France, Switzerland, Spain, Italy, Norway, and Sweden, suggesting an increased use of the substance in Western Europe. [Copyright &y& Elsevier]

Data on current use levels of E950 acesulfame K, E952 cyclamic acid and its Na and Ca salts, E954 saccharin and its Na, K and Ca salts, E955 sucralose and E957 thaumatin, have been collected by the European food and drink industry in response to an EFSA call for data in support of its upcoming review of low/no calorie sweeteners (LNCSs). Careful evaluation of these data is necessary to allow for reasonably realistic estimations of consumer intake. Consumer patterns of product use and in particular of "niche" products, which are not likely to represent general LNCS exposure, are important to consider. Market survey data can identify food categories where the frequency of use of a given LNCS is so low as to represent a niche use of the product. The subsequent incorporation of information about these niche products can provide a relevant improvement in obtaining realistic exposure calculations. Using this approach, estimates of exposure are found to be comparable with previously published papers on intake and show levels generally below current ADIs, for most population groups.