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2. Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts.

Author

Muso E, Endo T, Itabashi M, Kakita H, Iwasaki Y, Tateishi Y, Komiya T, Ihara T, Yumura W, Sugiyama T, Joh K, and Suzuki K

Subjects
Adult, Aged, Aged, 80 and over, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis classification, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis epidemiology, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis immunology, Biomarkers blood, Biopsy, China epidemiology, Disease Progression, Europe epidemiology, Female, Glomerulonephritis classification, Glomerulonephritis epidemiology, Glomerulonephritis immunology, Humans, Japan epidemiology, Kidney Failure, Chronic epidemiology, Kidney Failure, Chronic immunology, Kidney Failure, Chronic pathology, Kidney Glomerulus immunology, Male, Middle Aged, Predictive Value of Tests, Prognosis, Terminology as Topic, Time Factors, Young Adult, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis pathology, Antibodies, Antineutrophil Cytoplasmic blood, Glomerulonephritis pathology, Kidney Glomerulus pathology, Peroxidase immunology
Abstract

The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized; however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.

Published
2013
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