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The processes of urban growth vary in space and time. There is a lack of model transferability, which means that models estimated for a particular study area and period are not necessarily applicable for other periods and areas. This problem is often addressed through scenario analysis, where scenarios reflect different plausible model realisations based typically on expert consultation. This study proposes a novel framework for data-driven scenario development which, consists of three components - (i) multi-area, multi-period calibration, (ii) growth mode clustering, and (iii) cross-application. The framework finds clusters of parameters, referred to as growth modes: within the clusters, parameters represent similar spatial development trajectories; between the clusters, parameters represent substantially different spatial development trajectories. The framework is tested with a stochastic dynamic urban growth model across European functional urban areas over multiple time periods, estimated using a Bayesian method on an open global urban settlement dataset covering the period 1975–2014. The results confirm a lack of transferability, with reduced confidence in the model over the validation period, compared to the calibration period. Over the calibration period the probability that parameters estimated specifically for an area outperforms those for other areas is 96%. However, over an independent validation period, this probability drops to 72%. Four growth modes are identified along a gradient from compact to dispersed spatial developments. For most training areas, spatial development in the later period is better characterized by one of the four modes than their own historical parameters. The results provide strong support for using identified parameter clusters as a tool for data-driven and quantitative scenario development, to reflect part of the uncertainty of future spatial development trajectories. A promising further application is to use the growth modes to characterize past spatial development patterns. A trend of increasingly dispersed patterns could be identified over the studied functional urban areas which calls for more detailed explorations. [Display omitted] • Extrapolate urban spatial development processes from multi-area, multiperiod historical data. • Establish data-driven urban spatial development scenarios. • Confirm low transferability from the calibration period to the projection period. • Manage uncertainty as most areas are better represented by different established scenarios than their historic trajectory. • Detect a dispersed spatial development trend across studied urban areas in Europe. [ABSTRACT FROM AUTHOR]