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To improve yield, weedicides are an essential component of production technology. This improvement in yield with pesticide application is only possible if the applied weedicide does not affect the main crop. Weedicide application poses two problems; environmental pollution, and negative interaction with the soil-plant nutrient system. The interaction of nutrient and weedicide restricts the uptake of nutrients which decreases the target yield. So, there is a need to manage the sources of nitrogen and weedicides not only for effective control of weeds but also for the improvement in crop yield. A study was conducted at the research area of the Institute of Soil and Environmental Sciences, University of Agriculture, Faisalabad to check the interactive effect of weedicide and nitrogen fertilizer sources on the growth and yield of wheat. The experiment comprised of two combinations of nitrogen fertilizer sources that were; Urea+DAP and CAN+NP. The weedicide "Atlantis (Mesosulfuron methyl + Iodosulfuron methyl sodium)" was applied at different times (before, with and after nitrogen fertilizer application). Recommended rates of N-P-K (120-80-60 kg ha-1, respectively) and weedicide (370 g ha-1) were applied following the treatment plan (i.e. T1 = Control (Without fertilizer and weedicide); T2 = Urea+DAP (Weedicide applied before 2nd dose of urea); T3 = Urea+DAP (Weedicide applied with 2-nd\ dose of urea); T4 = Urea+DAP (Weedicide applied after 2-nd\ dose of urea); T5 =CAN+NP (Weedicide applied before 2-nd\ dose of CAN); T6 = CAN+NP (Weedicide applied with 2-nd\ dose of CAN); T7= CAN+NP (Weedicide applied after 2-nd\ dose of CAN)). The experiment was laid out according to Ra-nd\omized Complete Block Design (RCBD). Sulfate of potash (SoP) was applied for potassium (K) in all the treatments at sowing. All P was applied at sowing while N was applied in splits. The fertilizer combination CAN+NP with weedicide application after the 2-nd\ dose of CAN gave encouraging results; as plant height, chlorophyll contents and grain yield was increased up to 26.3, 30.8 a-nd\ 18.1 % in comparison to that of weedicide applied at the same time in Urea+DAP combination. Thus, the combination of CAN+NP as a nutrient source with weedicide application after the 2-nd\ dose of CAN could be beneficial for better crop quality/yield. Keywords: Weedicide, nitrogen fertilizer sources, urea+dap combination, can+np combination, yield of wheat. [ABSTRACT FROM AUTHOR]