1. SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
- Author
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Johnson J, Hague SM, Hanson M, Gibson A, Wilson KE, Evans EW, Singleton AA, McInerney-Leo A, Nussbaum RL, Hernandez DG, Gallardo M, McKeith IG, Burn DJ, Ryu M, Hellstrom O, Ravina B, Eerola J, Perry RH, Jaros E, Tienari P, Weiser R, Gwinn-Hardy K, Morris CM, Hardy J, and Singleton AB
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, DNA Mutational Analysis, England epidemiology, Family Health, Female, Finland epidemiology, Gene Dosage, Gene Expression Regulation, Genetic Predisposition to Disease, Hispanic or Latino genetics, Humans, Lewy Body Disease epidemiology, Male, Middle Aged, Nerve Tissue Proteins physiology, Parkinson Disease epidemiology, Synucleins, United States epidemiology, White People genetics, alpha-Synuclein, Gene Duplication, Lewy Body Disease genetics, Nerve Tissue Proteins genetics, Parkinson Disease genetics
- Abstract
The authors recently have shown that triplication of the alpha-synuclein gene (SNCA) can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. The authors assessed 101 familial PD probands, 325 sporadic PD cases, 65 patients with dementia with Lewy bodies, and 366 neurologically normal control subjects for SNCA multiplication. The authors did not identify any subjects with multiplication of SNCA and conclude this mutation is a rare cause of disease.
- Published
- 2004
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