1. Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
- Author
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McCullough ML, Weinstein SJ, Freedman DM, Helzlsouer K, Flanders WD, Koenig K, Kolonel L, Laden F, Le Marchand L, Purdue M, Snyder K, Stevens VL, Stolzenberg-Solomon R, Virtamo J, Yang G, Yu K, Zheng W, Albanes D, Ashby J, Bertrand K, Cai H, Chen Y, Gallicchio L, Giovannucci E, Jacobs EJ, Hankinson SE, Hartge P, Hartmuller V, Harvey C, Hayes RB, Horst RL, and Shu XO
- Subjects
- Adult, Analysis of Variance, Case-Control Studies, China epidemiology, Cohort Studies, Endometrial Neoplasms epidemiology, Endometrial Neoplasms ethnology, Endometrial Neoplasms prevention & control, Esophageal Neoplasms epidemiology, Esophageal Neoplasms ethnology, Esophageal Neoplasms prevention & control, Female, Finland epidemiology, Humans, Kidney Neoplasms epidemiology, Kidney Neoplasms ethnology, Kidney Neoplasms prevention & control, Logistic Models, Lymphoma, Non-Hodgkin epidemiology, Lymphoma, Non-Hodgkin ethnology, Lymphoma, Non-Hodgkin prevention & control, Male, Neoplasms ethnology, Ovarian Neoplasms epidemiology, Ovarian Neoplasms ethnology, Ovarian Neoplasms prevention & control, Pancreatic Neoplasms epidemiology, Pancreatic Neoplasms ethnology, Pancreatic Neoplasms prevention & control, Prospective Studies, Risk Factors, Stomach Neoplasms epidemiology, Stomach Neoplasms ethnology, Stomach Neoplasms prevention & control, United States epidemiology, Vitamin D Deficiency ethnology, Vitamin D Deficiency prevention & control, Neoplasms prevention & control, Vitamin D blood, Vitamin D therapeutic use, Vitamin D Deficiency complications, Vitamin D Deficiency epidemiology
- Abstract
Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentrations measured in a single laboratory were examined in 4,723 cancer-free men and women from 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers, which covers a worldwide geographic area. Demographic and lifestyle characteristics were examined in relation to 25(OH)D using stepwise linear regression and polytomous logistic regression. The prevalence of 25(OH)D concentrations less than 25 nmol/L ranged from 3% to 36% across cohorts, and the prevalence of 25(OH)D concentrations less than 50 nmol/L ranged from 29% to 82%. Seasonal differences in circulating 25(OH)D were most marked among whites from northern latitudes. Statistically significant positive correlates of 25(OH)D included male sex, summer blood draw, vigorous physical activity, vitamin D intake, fish intake, multivitamin use, and calcium supplement use. Significant inverse correlates were body mass index, winter and spring blood draw, history of diabetes, sedentary behavior, smoking, and black race/ethnicity. Correlates varied somewhat within season, race/ethnicity, and sex. These findings help identify persons at risk for low vitamin D status for both clinical and research purposes.
- Published
- 2010
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