1. [Molecular genetics in nephrology. Genetic kidney diseases provide clues for understanding the pathogenesis of proteinuria].
- Author
-
Huber TB and Benzing T
- Subjects
- Adult, Animals, Child, Finland, Glomerular Filtration Rate, Glomerulosclerosis, Focal Segmental genetics, Glomerulosclerosis, Focal Segmental physiopathology, Glomerulosclerosis, Focal Segmental therapy, Humans, Infant, Newborn, Kidney Diseases physiopathology, Kidney Diseases therapy, Kidney Failure, Chronic genetics, Kidney Failure, Chronic physiopathology, Kidney Failure, Chronic therapy, Kidney Glomerulus physiology, Kidney Glomerulus physiopathology, Membrane Proteins, Mice, Mutation, Nephrotic Syndrome congenital, Nephrotic Syndrome genetics, Nephrotic Syndrome therapy, Proteins genetics, Proteinuria genetics, Proteinuria physiopathology, Genetic Predisposition to Disease, Kidney Diseases genetics, Proteinuria etiology
- Abstract
Recent progress in defining the genetic basis of inherited glomerular diseases has provided a completely new understanding of the glomerular filter of the kidney and has helped illuminate the pathogenesis of acquired and inherited renal proteinuric diseases. Based on the findings of molecular genetics in nephrology we will discuss the current understanding of the glomerular filter and provide an idea how genetic testing in the future may help to guide therapy in patients suffering from nephrotic syndrome and progressive renal failure.
- Published
- 2003
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