1. Prothrombin Gainesville. A dysprothrombinemia in a pair of identical twins.
- Author
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Smith LG, Coone LA, and Kitchens CS
- Subjects
- Adult, Diseases in Twins blood, Female, Florida, Hemostasis, Humans, Hypoprothrombinemias blood, Hypoprothrombinemias complications, Hysterectomy, Metrorrhagia blood, Metrorrhagia complications, Pedigree, Pregnancy, Diseases in Twins congenital, Hypoprothrombinemias congenital, Prothrombin immunology, Twins, Twins, Monozygotic
- Abstract
A pair of identical twins was evaluated for menometrorrhagia and mild post-operative bleeding. Each had a slightly prolonged partial thromboplastin time and prothrombin time. Full hemostatic evaluation was normal, except that plasma prothrombin activity was 23% and 25% of normal with a Russell's viper venom assay. Each twin had 70% of normal plasma prothrombin antigen. Prothrombin kinetic data were obtained before and during hysterectomy. In these twins, infused prothrombin (Konyne) was found to have a volume of distribution of approximately one and one-half times the plasma volume and a half-life of 34 hours. The previously reported dysprothrombins are briefly reviewed. Prothrombin Gainesville is the twelfth such disorder reported.
- Published
- 1981
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