1. Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France.
- Author
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Thoisy, Alix De, Woudenberg, Tom, Pelleau, Stéphane, Donnadieu, Françoise, Garcia, Laura, Pinaud, Laurie, Tondeur, Laura, Meola, Annalisa, Arowas, Laurence, Clement, Nathalie, Backovic, Marija, Ungeheuer, Marie-Noëlle, Fontanet, Arnaud, White, Michael, and teams, COVID-Oise and SeroPed study
- Subjects
IMMUNOGLOBULIN G ,CORONAVIRUSES ,SEROCONVERSION ,COHORT analysis ,HUMAN beings - Abstract
Background The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed. Methods In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay. Results The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22–0.47 year
−1 for children, and 0.13–0.27 year−1 for adults. Seroreversion was estimated as 0.31–1.37 year−1 in children and 0.19–0.72 year−1 in adults. The estimated seroconversion rate in children was consistent with 20%–39% of children being infected every year with each HCoV. Conclusions The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children. [ABSTRACT FROM AUTHOR]- Published
- 2023
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