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Abstract: This study details the phylogeographic pattern of the white-throated dipper (Cinclus cinclus), a Palearctic, temperate, passerine bird that is exclusively associated with flowing water. Our results reveal a complex phylogeographic structure with at least five distinct lineages for the Western Palearctic region. As for many species of the Western Palearctic fauna and flora, this genetic structure is probably linked to the isolation of populations in different southern refuges during glacial periods. Furthermore, the isolation of populations in Scandinavia and/or Eastern regions, but also in Morocco and probably in Corsica, was accentuated by ecological and biogeographic barriers during Quaternary interglacial periods. During glacial periods, Italy, Sicily and the Balkano-Carpathian region acted as major refuge zones for the dipper. At the end of the last ice age, Western Europe was repopulated by dippers from an Italian refuge, while Eastern Europe was recolonised by Balkano-Carpathian birds. A large contact zone between these two lineages was evidenced and extends from Luxembourg to Hungary. Finally, our results indicate the need to clarify the taxonomic status of the dipper, especially concerning the European subspecies whose validity appears uncertain. [Copyright &y& Elsevier]

[Display omitted] • [NO x ], [NH 4 +] and [Si(OH) 4 ] increased but [PO 4 3−] decreased between 2000 and 2019. • Seagrass meadow decline directly and indirectly explained through: • Reduced nutrient consumption and sediment stabilization. • Increased phytoplankton biomass with high P-need. • Increase in temperature and changes in wind conditions also mattered. Large amounts of nutrients have been released to the coastal ecosystems during the 20th century. Since then, management policies have been implemented and these amounts decreased in the economically developed countries. We examined the bi-decadal changes in nutrients (nitrate + nitrite, ammonium, orthophosphate and silicic acid) in the Arcachon bay, a semi-enclosed lagoon that hosts one of the largest but declining seagrass meadow in Europe. Seven sites have been sampled for nutrients and biogeochemical parameters during twenty years at low and/or high tide. In addition, continental and climatic data as well as hydro-climatic indices were used. Dynamic linear models were used to assess the bi-decadal changes in nutrient concentrations and ratios, their seasonality, and the bi-decadal changes of their potential drivers. Partial least square path modeling were used to investigate the relationships between potential abiotic drivers and nutrients. During the study period, the concentration of N and Si nutrients increased whereas the concentration of orthophosphate decreased, leading to deep changes in nutrient ratios. Clear relationships between abiotic drivers (local climate, continental inputs and the bay hydrodynamism) and N, P and Si nutrients were highlighted. However, the bi-decadal change in nutrient concentrations and ratios was mainly ascribed to the seagrass meadow decline through direct (less nutrient consumption) and indirect (increase in phytoplankton biomass) processes. Changes in temperature and wind direction may also influenced the nutrients concentrations through processes of remineralisation and flushing time, respectively. This study illustrates (1) the top-down control of seagrass on the nutrients concentrations and stoichiometry, and (2) the competition between primary producers (seagrass vs phytoplankton) for their nutrients resource. [ABSTRACT FROM AUTHOR]

Background: Crohn's disease (CD) is a chronic disorder requiring long-term treatment. However, up to 20% of patients interrupt temporarily or permanently anti-TNFα. Primary aim was to identify internal and external factors influencing patient's motivation to pursue anti-TNFα in active CD., Methods: This was a French, multicentre, prospective study enrolling CD patients on anti-TNFα therapy since more than 3 months. Patients completed the Satisfaction of Patients with Crohn's Disease questionnaire (SPACE-Q) and other patient-reported-outcome tools at inclusion visit, and after 6 and 12 months., Results: A total of 274 patients were included: 146 (53.3%) received adalimumab, while 128 (46.7%) infliximab. Most patients (78%) were still treated with anti-TNFα 12 months after enrolment. Patients' perception of necessity (p = 0.01) and concerns (p<0.0001) regarding medication, evaluated through the Belief about Medicines Questionnaire (BMQ), and expectation confirmation towards treatment convenience (p = 0.02), towards efficacy (p = 0.04), and treatment satisfaction (p = 0.03) according to SPACE-Q, correlated with motivation to pursue treatment. Patients with higher treatment satisfaction (p = 0.0004), stronger belief in treatment necessity (p<0.0001) and fewer concerns (p = 0.0002) were more likely to be very motivated., Conclusion: Treatment satisfaction, treatment necessity, and concerns are correlated to motivation to pursue anti-TNFα. Specific questions focused on these patients' perceptions could help physicians to identify patients at risk of non-adherence and prevent therapy interruption., Competing Interests: Declaration of Competing Interest F. D'Amico declares no conflict of interest. L. Peyrin-Biroulet has served as a speaker, consultant and advisory board member for Merck, Abbvie, Janssen, Genentech, Mitsubishi, Ferring, Norgine, Tillots, Vifor, Hospira/Pfizer, Celltrion, Takeda, Biogaran, Boerhinger-Ingelheim, Lilly, HAC- Pharma, Index Pharmaceuticals, Amgen, Sandoz, For- ward Pharma GmbH, Celgene, Biogen, Lycera, Samsung Bioepis, Theravance. L. Vandromme has served as consultant for Abbvie Laboratories. Y. Bounhik received consulting and lecture fees from AbbVie, Biogaran, Biogen, Boehringer Ingelheim, Celgene, Ferring, Gilead, Hospira, Janssen, Mayoli Spindler, MSD, Norgine, Pfizer, Roche, Samsung Bioepis, Sandoz, Sanofi, Shire, Takeda, UCB. P.Faure has served as consultant for Abbvie Laboratories. S. Nahon has served as consultant for Abbvie Laboratories. H. Hagège has served as consultant for Abbvie, Alfasigma, Ferring, Janssen, Norgine, Mayoly Spindler, MSD, Takeda, Tillotts. X. Hebuterne has served on advisory boards for Abbvie, Abivax, Alphasigma, ARARD, Arkopharma, Astellas, Baxter, Bristol Myers Squibb, Cellgen, Gilead, Eli Lilly, Enterome, Ferring, Fresenius-Kabi, InDex Pharmaceuticals, Janssen, MSD, Nutricia, Pfizer, Roche, Sanofi-Advantis, SAlix, Sangamo, Takeda, Theravance, Tillots. S. Benkhalifa is employee of Abbvie. M. Nachury has served as consultant for Abbvie, Adacyte, Amgen, Biogen, Ferring, Janssen, Mayoli-Spindler, MSD, and Takeda., (Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)

The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has required a complete change in the management of patients with inflammatory bowel disease (IBD) who need to undergo endoscopic procedures. Several preventive measures must be taken to avoid the spread of infection among health-care professionals and patients with IBD, including the use of personal protective equipment, greater attention to endoscopic room hygiene and rescheduling of non-urgent procedures. This Perspective aims to provide a guide based on the Italian and French experience to better face the difficulties encountered by endoscopists during this global health emergency. In particular, recommendations regarding the use of personal protective equipment to prevent COVID-19 transmission, both for patients and health-care professionals, are proposed and different scenarios in endoscopic IBD management are evaluated to suggest when endoscopy could be rescheduled and replaced by alternative biomarkers.

The endemic Pyrenean Desman (Galemys pyrenaicus) is an elusive, rare, and vulnerable species declining over its entire and narrow range (Spain, Portugal, France, and Andorra). The principal set of conservation measures in France is a 5-years National Action Plan based on 25 conservation actions. Priority is given to update its present distribution and develop tools for predictive distribution models. We aim at building the first species distribution model and map for the northern edge of the range of the Desman and confronting the outputs of the model to target conservation efforts in the context of environmental change. Contrasting to former comparable studies, we derive a simpler model emphasizing the importance of factors linked to precipitation and not to the temperature. If temperature is one of the climate change key factors, depicted shrinkage in Desman distribution could be lower or null at the northern (French) edge suggesting thus a major role for this northern population in terms of conservation of the species. Finally, we question the applied issue of temporal and spatial transferability for such environmental favourability models when it is made at the edge of the distribution range.